Histological study of pathological root resorption in human deciduous teeth with apical periodontitis.

人乳牙根尖周炎病理性牙根吸收的组织学研究。

基本信息

  • 批准号:
    09672089
  • 负责人:
  • 金额:
    $ 2.24万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1999
  • 项目状态:
    已结题

项目摘要

The purpose of this study was to examine a different root resorption process on the root dentin with apical periodontitis or on sound root dentin.1. The region of the root apex with severe apical periodontitis in human deciduous teeth was observed by light and transmission electron microscopy. Root dentin and original cementum had a severe irregular caved surface due to pathological root resorption. Cementum had partial!y deposited on the caved dentin and original cementum surfaces. The structure of deposited cementum was very different from that of the original cementum. It was thought that partial repair mechanisms such as cementum deposition are affected by the surrounding environment of the root.2. Root dentin slices were prepared from human deciduous teeth with apical periodontitis (group p) or sound human deciduous teeth (group n, control). Cell suspension of bone marrow from the femur of mice in α MEM was seeded on the dentin slices and incubated. After incubation, specimens wer … More e removed and fixed, and then observed for tartrate-resistant acid phosphatase (TRAP) activity. The number of TRAP-positive cells on the dentin was calculated by light microscopic observation. TRAP-positive cells were observed in all dentin slices. There were no significant differences between group p and group n on the number of TRAP-positive cells by Mann-Whitney test. The results suggested that root dentin with apical periodontitis was resorbed by cultured osteoclasts It was thought that enviromental factors in root circumferences had a greater effect than does the condition of root dentin on pathological root resorption.3. The root dentin slices of group p and group n were embedded in rats subcutaneous tissue. The dentin slices of both groups were surrounded by fibrous connective tissue are inflammatory cells and partially resorbed by multinuclear giant cells. However, the resorption was slight. There were no differences between the both groups on the condition of the dentin slices. It was thought that the condition of root dentin had few effect on pathological root resorption.Therefore, it was suggested that enviromental factors in root circumferences had a great effect on patholagical root resorption. Less
本研究的目的是探讨患有根尖周炎的牙根牙本质和健全的牙根牙本质的不同牙根吸收过程。 1.通过光镜和透射电子显微镜观察人类乳牙患有严重根尖周炎的根尖区域。由于病理性牙根吸收,牙骨质部分沉积在凹陷的牙本质和原始牙骨质上,因此牙根牙本质和原始牙骨质具有严重不规则的凹陷表面。沉积牙骨质的结构与原始牙骨质的结构有很大不同,认为牙骨质沉积等部分修复机制受到牙根周围环境的影响。2.将来自小鼠股骨的根尖牙周炎(p组)或健全的人乳牙(n组,对照)的细胞悬浮液接种在牙本质切片上并孵育。孵育后,取出并固定标本,然后观察抗酒石酸酸性磷酸酶(TRAP)活性。通过光镜观察计算牙本质上TRAP阳性细胞的数量。 Mann-Whitney 试验结果显示,p 组和 n 组的牙本质切片中 TRAP 阳性细胞数量无显着性差异,提示根尖周炎的牙根牙本质呈阳性。培养破骨细胞吸收 认为牙根周长的环境因素对病理性牙根吸收的影响大于牙根牙本质的状况。 3.p组和n组的牙根牙本质切片包埋于大鼠皮下组织切片中。两组均被纤维结缔组织包围,均为炎性细胞,部分被多核巨细胞吸收,但两组间吸收程度无差异。牙本质切片的状况被认为对病理性牙根吸收的影响较小。因此,提示牙根周长的环境因素对病理性牙根吸收的影响较小。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

YAWAKA Yasutaka其他文献

N-acetylcysteine attenuates PGE2 and ROS production stimulated by 4-META/MMA-based resin in murine osteoblastic cells
N-乙酰半胱氨酸减弱小鼠成骨细胞中 4-META/MMA 基树脂刺激的 PGE2 和 ROS 产生
  • DOI:
    10.4012/dmj.2020-275
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    NAKAMURA Koichi;MINAMIKAWA Hajime;TAKAHASHI Shizuka;YOSHIMURA Yoshitaka;YAWAKA Yasutaka
  • 通讯作者:
    YAWAKA Yasutaka

YAWAKA Yasutaka的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('YAWAKA Yasutaka', 18)}}的其他基金

Control of complicated root canal system of primary teeth: For good results of root canal treatment with apical periodontitis
乳牙复杂根管系统的控制:根尖周炎根管治疗取得良好效果
  • 批准号:
    22592276
  • 财政年份:
    2010
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似国自然基金

Fe3O4-PAMAM通过调控成骨-破骨平衡促进难治性根尖周炎骨修复的机制研究
  • 批准号:
    82301058
  • 批准年份:
    2023
  • 资助金额:
    30 万元
  • 项目类别:
    青年科学基金项目
凋亡囊泡转运TRIM21调控巨噬细胞糖酵解治疗根尖周炎的作用机制研究
  • 批准号:
    82370942
  • 批准年份:
    2023
  • 资助金额:
    47 万元
  • 项目类别:
    面上项目
靶向调控Gremlin1经FGFR1/STAT3信号通路促进巨噬细胞胞葬对根尖周炎消退的影响及机制研究
  • 批准号:
    82301057
  • 批准年份:
    2023
  • 资助金额:
    30 万元
  • 项目类别:
    青年科学基金项目
噬菌体内溶素通过靶向致病性粪肠球菌介导巨噬细胞极化治疗难治性根尖周炎的作用机制研究
  • 批准号:
    82360189
  • 批准年份:
    2023
  • 资助金额:
    32 万元
  • 项目类别:
    地区科学基金项目
成骨细胞靶向性工程化sEV递送miR-21在慢性根尖周炎中的作用与机制研究
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    52 万元
  • 项目类别:
    面上项目

相似海外基金

炎症反応を応用した新規再生因子キャリアによる根尖性歯周炎の治療法開発
开发利用炎症反应的新型再生因子载体治疗根尖周炎的方法
  • 批准号:
    24K12923
  • 财政年份:
    2024
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Evaluation of the Role of Macrophage Migratory Inhibitory Factor (MIF) in mediating Stem Cell Analgesia in a Model of Orofacial Pain
评估巨噬细胞迁移抑制因子(MIF)在口面部疼痛模型中介导干细胞镇痛的作用
  • 批准号:
    10585412
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
Multifunctional Roles of AgI/II Family Proteins
AgI/II 家族蛋白的多功能作用
  • 批准号:
    10750344
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
Evaluation of Trigeminal Ganglia Sensory Neuronal Population/s Mediating MIF-Induced Anti-Nociception in a Model of Apical Periodontitis.
根尖周炎模型中三叉神经节感觉神经元群介导 MIF 诱导的抗伤害感受的评估。
  • 批准号:
    10822712
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
メタオミクスと質量分析イメージングによる根尖性歯周炎の再発マーカー因子探索
利用元组学和质谱成像寻找根尖周炎复发标志物
  • 批准号:
    22K09962
  • 财政年份:
    2022
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了