IMSD at Rush University

拉什大学 IMSD

• 批准号: 10554321
• 负责人: Lena Al-Harthi
• 金额: $ 49.58万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554321
• 关键词: Universities

Project summary/abstract: National data on career choices of emerging scientists indicate that less than 25% pursue a traditional independent pathway in an academic environment. This grim reality is even worse for underrepresented minorities (URM), who represent 39% of college age individuals yet only 13% of PhDs in life sciences. In 2015, we were awarded a NIGM R25 Initiative for Maximizing Student Development (Rush-IMSD). Rush R25-IMSD was charged with training pre-doctoral URMs in biological sciences at Rush University in Chicago, IL. Although Rush R25-IMSD was a budding program, we achieved an impressive track record in our first 5 years of training and retaining of PhD URMs students, some of whom received F31s and/or research supplement awards. This formal structure dedicated to URM PhD training, a first at Rush, was instrumental in building alliances to promote URM education within and outside of our university. Specifically, Rush R25-IMSD is a documented success aligned with institutional commitment for diversity and inclusion. With the recognition that minorities continue to be underrepresented in PhD life science programs, and consequently the biomedical workforce does not reflect the diversity of our nation, we propose a new program for training of URM PhD students at Rush University under a T32 mechanism (as NIGM is phasing out R25 IMSDs). The pillars of T32 IMSD-Rush is a triad of rigorous mentoring, education, and research training of pre- doctoral URM students through harnessing the expertise of nationally recognized mentors and program faculty across several departments. Three students per year will be selected to participate in T32 IMSD-Rush and supported for the first three years of matriculation (an additional participant will be under institutional support). Together, we expect a cohort of 20 students over five years. The overarching goal of T32 IMSD-Rush will be attained through two interrelated specific aims: 1) Train emerging URM scientists in technical and operational basis of discipline-based research: T32 IMSD-Rush will be inter-and multidisciplinary program for training of URM PhD students in one of several disciplines (immunology/microbiology, physiology and biophysics, cell and molecular medicine, neurologic sciences, orthopedics/bioengineering). Participants will select a discipline and be matched with a primary mentor who along with nationally recognized leaders will guide the research development of the participant from idea conception to successful execution (e.g., the operational phase of training include knowledge acquisition, rigorous experimental design and data interpretation). Participants will also be trained in highly innovative and cutting-edge technology that can be used across disciplines to address impactful scientific questions and discoveries through designated workshops in imaging (live cell imaging, CT scans, confocal microscopy), small animal models (animal care, humanized mice, transgenic rats), molecular approaches (RNA/DNA scope, quantitative gene knockdown), quantitative and computational approaches (high-input statistics, bioinformatics) and training in scientific reproducibility and rigor. The participants will be captured early and integrated into the program through pre-matriculation (summer) training modules. Milestones include submission and acquisition of NIH individual predoctoral awards (F31) or individual predoctoral to postdoctoral fellow transition award (F99/K00), publication of two peer-reviewed manuscripts, one of which as a first author, and successful completion of the PhD program. 2) Implement and optimize best practices for training of emerging URM science investigators: Classical mentorship relies heavily on scientific research prowess. There is a greater recognition and appreciation that mentorship should be a holistic strategy, combining training in rigor in research with professional skills and network/alliance building to facilitate the development of a well-rounded emerging scientist, one who will successfully face the challenges of academic research, in particular, and of science in general. T32 IMSD-Rush will provide URM mentorship through direct and regular one-on-one contact and organized activities through workshops to maximize each participant’s professional development. These programs will include training modules on poster and oral presentations, emotional intelligence, conflict resolution, verbal and non-verbal communication, negotiations, financial budgeting/fiscal responsibility of running a team and/or lab, interviewing skills and most importantly building a culture of inclusion as a supportive network for URMs. Best practices will be used to train the participants. Mentors/program faculty will undergo mentorship training established by the National Research Mentoring Network (NRMN). Collectively, these initiatives are the cornerstones to ensure that T32 IMSD-Rush participants will be fully prepared to navigate the demands and challenges facing URM scientists. T32 IMSD-Rush will be evaluated through a well-integrated process to track, report, and assess long- term outcomes of trainees. Our findings will be shared through open dissemination of information and networking with organizations with similar interest. Our long-term goal is to increase enrollment of PhD URM students in biomedical sciences at Rush by at least 50%, with 90% successfully completing the program, and ≥50% will choose post-graduate training. Also, we envision that T32 IMSD-Rush instituted model for graduate student training will evolve into a platform that has university and community sustainability and sustained partnerships.

项目摘要/摘要：有关新兴科学家职业选择的国家数据，表明不到25％ 在学术环境中追求传统的独立途径。这种严峻的现实甚至更糟 代表不足的少数族裔（URM），占大学年龄个人的39％，但生活中只有13％ 科学。 2015年，我们获得了一项nigm R25倡议，以最大化学生发展（Rush-IMSD）。 Rush R25-IMSD被控在Rush University的生物科学培训培训前URM 伊利诺伊州芝加哥。尽管Rush R25-IMSD是一个崭露头角的节目，但我们在我们的 培训和保留博士URMS学生的前5年，其中一些人接受了F31和/或研究 补充奖项。这种专门用于URM博士培训的正式结构是Rush的首次培训，在 建立联盟以促进我们大学内外的URM教育。特别是Rush R25-IMSD 是有记录的成功与机构对多样性和包容性的承诺保持一致的。 认识到少数民族在博士学位科学计划中的人数仍然不足，并且 因此，生物医学劳动力并不能反映我们国家的多样性，我们提出了一个新计划 用于根据T32机制在Rush University的URM博士学位培训（因为Nigm逐步淘汰R25 IMSD）。 T32 IMSD-RUSH的支柱是严格的心理，教育和研究培训的三合会。 博士URM学生通过利用全国认可的导师和计划教师的专业知识 在几个部门。每年将选择三名学生参加T32 IMSD-RUSH和 在矩阵的前三年得到支持（其他参与者将得到机构支持）。 我们预计将在五年内组成20名学生。 T32 IMSD-Rush的总体目标将是 通过两个相互关联的特定目的获得： 1）以基于学科的研究的技术和运营基础来培训新兴的URM科学家： T32 IMSD-Rush将是跨学科的跨学科课程，用于培训几种URM博士学位学生 学科（免疫学/微生物学，生理学和生物物理学，细胞和分子医学，神经系统 科学，骨科/生物工程）。参与者将选择一门学科，并与主要的精神匹配 谁与全国认可的领导者一起指导参与者的研究发展 成功执行的概念（例如，培训的操作阶段包括知识获取， 严格的实验设计和数据解释）。参与者还将接受高度创新的培训 尖端的技术可用于跨学科来解决有影响力的科学问题和 通过成像中的指定研讨会（活细胞成像，CT扫描，共聚焦显微镜）的发现，小 动物模型（动物护理，人性化小鼠，转基因大鼠），分子方法（RNA/DNA范围， 定量基因敲低），定量和计算方法（高输入统计，生物信息学） 以及科学可重复性和严格性的培训。参与者将提早捕获并融入 通过注册前（夏季）培训模块进行程序。里程碑包括提交和收购 NIH个人奖项（F31）或博士后同胞过渡奖的个人奖项 （F99/k00），两份同行评审的手稿的出版，其中之一是第一作者，并成功 博士课程的完成。 2）实施并优化培训新兴URM科学研究者的最佳实践： 经典的精神统治在很大程度上取决于科学研究的能力。有更大的认可和 欣赏精神训练应该是一种整体策略，将严格研究的培训结合在一起 专业技能和网络/联盟建设，以促进开发全面的新兴 科学家，将成功面对学术研究的挑战，尤其是科学的科学家 一般的。 T32 IMSD-Rush将通过直接和常规的一对一联系来提供URM Mentalship，并且 通过研讨会组织活动，以最大化每个参与者的专业发展。这些 计划将包括有关海报和口头演示的培训模块，情商，冲突 解决方案，口头和非语言交流，谈判，财务预算/财政责任 团队和/或实验室，采访技能，最重要的是建立一种包容性文化作为支持网络 对于URMS。最佳实践将用于培训参与者。导师/课程教师将接受指导 国家研究指导网络（NRMN）建立的培训。 总的来说，这些举措是确保T32 IMSD-RUSH参与者完全的基石 准备应对URM科学家面临的需求和挑战。 T32 IMSD-RUSH将通过整合的过程进行评估，以跟踪，报告和评估长期 学期成果。我们的发现将通过公开传播信息和网络共享 与具有相似兴趣的组织。我们的长期目标是增加博士学位学生的入学率 Rush的生物医学科学至少达到50％，90％成功完成了该计划，≥50％将 选择研究生培训。此外，我们设想T32 IMSD-Rush为研究生建立了模型 培训将演变成具有大学和社区可持续性和持续合作伙伴关系的平台。