Association of Perceived Stress and Cognition

感知压力与认知的关联

基本信息

批准号：
10552041
负责人：
Ambar Kulshreshtha
金额：
$ 17.94万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-15 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10552041
关键词：
Address Affect African American African American population Aging Alzheimer disease prevention Alzheimer&apos s Disease Amyloid beta-Protein Area Attention Behavior Behavior Therapy Behavioral Mechanisms Biological Markers Blood Vessels Board Certification Brain Cardiovascular Diseases Chronic stress Clinical Clinical Research Clinical Trials Cognition Cognitive Cohort Studies Complex Data Analyses Dementia Diet Discrimination Disease Disparity Elderly Episodic memory Ethnic Origin Event Family Physicians Family Practice Foundations Glucocorticoids Goals Health Hormones Impaired cognition Incidence Individual Intervention Knowledge Life Life Cycle Stages Literature Longitudinal Studies Measurement Measures Mediating Memory Mentored Patient-Oriented Research Career Development Award Minority Groups Modification Nature Nerve Degeneration Neuropsychology Online Systems Outcome Pathway interactions Patients Pattern Persons Population Prevalence Prevention Prevention strategy Preventive Medicine Primary Care Program Description Psychological Stress Public Health Questionnaires Race Reasons for Geographic And Racial Differences in Stroke Reduce health disparities Research Research Personnel Risk Factors Role Smoking Socioeconomic Factors Stress Subgroup Testing Training Training Programs United States United States National Institutes of Health Universities Work abeta deposition acceptability and feasibility cardiovascular disorder epidemiology cardiovascular disorder risk cardiovascular risk factor career clinical care cognitive function cognitive performance cohort coping design disease disparity executive function experience health disparity high risk high risk population hypothalamic-pituitary-adrenal axis improved interdisciplinary approach lifestyle intervention mild cognitive impairment minority stress modifiable risk multidisciplinary neurodevelopment novel patient oriented perceived discrimination perceived stress physical inactivity prevent primary outcome prodromal Alzheimer&apos s disease programs prospective psychosocial stressors racial population specific biomarkers stress reduction stressor tau Proteins web-based intervention

项目摘要

Project/Summary Abstract African Americans are twice as likely to develop Alzheimer's disease (AD) as Whites, but few studies have focused on these cognitive disparities and related mechanisms. Perceived stress in minority groups such as African Americans, directly affects cognition and also plays a role in worsening of CVD risk factors and unhealthy behaviors such as smoking, improper diet, and physical inactivity. Further understanding the role of modifiable risk factors such as perceived stress in cognitive decline could have an important role in developing effective preventive strategies and addressing health disparities in aging populations. The overarching goal of this proposal is to examine the association of stress and cognition, role of CVD risk factors, and related health disparities. The research proposed in this Mentored Patient-Oriented Research Career Development Award includes data analyses involving two cohort studies and determining the feasibility of a pilot clinical trial. The plan describes three separate but interrelated projects designed to examine the association of perceived stress and cognition. Specific Aim-1: The study will prospectively examine the relationship between perceived stress and incident cognitive impairment among African Americans and Whites in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort (n=30,239) and explore if CVD risk factors mediate this relationship. Specific Aim-2: The study will assess the relationship of perceived stress with specific cognitive domains among African Americans and Whites with Mild Cognitive Impairment in the Vascular Contributors to Prodromal Alzheimer's disease (VASCULAR) cohort study (n=341) at Emory. Specific Aim-3: The study will determine the feasibility of a novel web-based multidisciplinary stress reduction program and assess the program's effects on perceived stress, related biomarkers, and cognition among African Americans and Whites with Mild Cognitive Impairment (n=30). Candidate: The candidate (Dr. Kulshreshtha) is a board certified Family Physician in the Department of Family and Preventive Medicine at Emory University. His long-term career goal is to become an independent clinician researcher investigating the mechanisms of behavioral and lifestyle interventions to improve cognitive health and reduce health disparities. The integrated research and training program described in this proposal will build on the candidate's prior experience in cardiovascular epidemiology, health disparities, and primary care clinical work. It will incorporate new training in cognitive and stress measurements, and clinical trials, to develop expertise in the area of stress and cognition research for AD prevention. Overall this research will form the basis for larger studies investigating potential mechanisms and interventions for AD prevention and establish Dr. Kulshreshtha as a young investigator in patient-oriented clinical research.

项目/摘要摘要非裔美国人患阿尔茨海默病 (AD) 的可能性是白人的两倍，但很少有研究表明重点关注这些认知差异和相关机制。少数群体感受到的压力，例如非裔美国人，直接影响认知，也在 CVD 危险因素恶化和不健康的行为，如吸烟、饮食不当和缺乏身体活动。进一步了解其作用可改变的风险因素，例如认知能力下降中的感知压力，可能在发展中发挥重要作用有效的预防策略并解决老龄化人口中的健康差距。总体目标该提案的目的是检查压力和认知的关联、CVD 危险因素的作用以及相关的健康差异。本指导性患者导向研究职业发展中提出的研究奖项包括涉及两项队列研究的数据分析以及确定试点临床试验的可行性。该计划描述了三个独立但相互关联的项目，旨在检查感知的关联压力和认知。具体目标 1：该研究将前瞻性地研究感知压力与事件之间的关系地理和种族原因中非裔美国人和白人的认知障碍中风 (REGARDS) 队列 (n=30,239) 的差异，并探讨 CVD 危险因素是否介导这种关系。具体目标 2：该研究将评估感知压力与特定认知领域的关系在血管贡献者中患有轻度认知障碍的非裔美国人和白人中埃默里大学的前驱阿尔茨海默病 (VASCULAR) 队列研究 (n=341)。具体目标 3：该研究将确定一种新颖的基于网络的多学科减压的可行性计划并评估计划对感知压力、相关生物标志物和认知的影响患有轻度认知障碍的非裔美国人和白人 (n=30)。候选人：候选人（Kulshreshtha 博士）是家庭部的委员会认证家庭医生和埃默里大学的预防医学。他的长期职业目标是成为一名独立的临床医生研究人员研究行为和生活方式干预改善认知健康的机制并减少健康差距。本提案中描述的综合研究和培训计划将以候选人之前在心血管流行病学、健康差异和初级保健方面的经验为基础临床工作。它将纳入认知和压力测量以及临床试验方面的新培训，以发展预防 AD 的压力和认知研究领域的专业知识。总体而言，本研究将形成为调查 AD 预防和干预的潜在机制和干预措施的更大规模研究奠定了基础将 Kulshreshtha 博士确立为以患者为导向的临床研究的年轻研究者。