Molecular, Cellular, and Circuit Mechanisms of Nociception Behavior

伤害感受行为的分子、细胞和回路机制

基本信息

批准号：
10552222
负责人：
William D Tracey
金额：
$ 39.63万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-10 至 2027-11-30
项目状态：
未结题

项目摘要

Abstract Nociception, the sensory mechanism that allows animals to sense and avoid potentially tissue-damaging stimuli, is critical for survival across species. Nociceptors are specialized neurons that detect and respond to potentially damaging factors through the expression of molecules that function to detect and signal the presence of potential harm. The primary focus of the research in my laboratory has been the study of nociception, however, we have also explored mechanisms underlying the sense of gentle touch, and most recently, the sense of proprioception. We have found that each of these senses relies on specific classes of non-ciliated multidendritic sensory neurons. The multidendritic neurons that are dedicated to a specific sensory modality are morphologically distinct from one another, and they have diverse patterns of gene expression. We seek to define how these distinct morphologies relate to function, and how ensembles of genes expressed within the distinct morphological types of neurons control sensory pathways of somatosensation with a primary focus on nociception. The overarching theme of our research program is understanding the molecular, cellular, and circuit, mechanisms underlying nociception. The primary goal of our research program in the next 5 years will be to further characterize the function of the nociception genes that we have identified using forward genetics. Our focus is on evolutionarily conserved genes that are not already understood to play important roles in nociception. These studies provide the greatest impact in creating new knowledge. In addition, we plan to begin to understand the neuronal network for nociception behavior.

抽象的伤害感受，即使动物感知并避免潜在的组织损害的感觉机制刺激对于跨物种生存至关重要。伤害感受器是检测和反应的专门神经元通过表达发挥作用的分子的表达来检测和发出信号的潜在破坏因素存在潜在伤害。研究在我的实验室中的主要重点是研究但是，伤害感受，我们还探索了柔和感的基础的机制，大多数最近，本体感受感。我们发现，这些感官中的每一个都依赖于特定类别非脱毛的多阶梯性感觉神经元。专用于特定感觉的多端神经元形态在形态上彼此不同，它们具有不同的基因表达模式。我们试图定义这些独特的形态与功能的关系，以及基因的集合如何表达在独特的形态类型中，神经元控制体感应的感觉途径专注于伤害感受。我们研究计划的总体主题是了解分子，细胞和电路，是伤害受伤的基础机制。我们的研究计划的主要目标 5年将是进一步表征我们使用的伤害感受基因的功能正向遗传学。我们的重点是尚未理解的进化保守基因在伤害感受中的重要作用。这些研究为创造新知识带来了最大的影响。在此外，我们计划开始了解伤害性行为的神经元网络。