NHLBI Logistical Support Services

NHLBI 后勤支持服务

• 批准号: 10551051
• 负责人: CHRISTINE HARTLEY
• 金额: $ 33.6万
• 依托单位: SYNERGY ENTERPRISES, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551051
• 关键词: Acquired Immunodeficiency Syndrome; Area; Chronic; Collaborations; Communities; Consultations; Discipline; Educational workshop; Epidemic; Fostering; HIV; Health; Immunosuppression; Investments; Logistics; Longevity; National Heart, Lung, and Blood Institute; Persons; Recommendation; Research; Services; United States National Institutes of Health; antiretroviral therapy; body system; co-infection; comorbidity; immune activation; response; success; symposium

The success of antiretroviral therapy (ART) has ushered in a new era for the HIV epidemic. People living with HIV (PLWH) can achieve nearly normal life-spans if treated with effective ART, in which case, they are more likely to suffer chronic HIV-related comorbidities, coinfections and complications (CCCs) than AIDS-defining conditions. Despite the success of ART, the impact of HIV, its treatment, and the legacy of chronic immune activation and immune suppression needs to be understood to optimize the health of PLWH. Efforts at NIH thus far have mostly targeted specific areas with few initiatives that encompass the impact on multiple organ systems or conditions simultaneously. NIH-wide scientific consultations are needed to gain a better understanding of common mechanisms, to identify gaps and opportunities for research in HIV-associated CCCs, and to foster cross-disciplinary collaborations in this area. Findings from such consultations are expected to help facilitate a coordinated NIH response to the growing needs for research on HIV-associated CCCs, specifically to target the highest priorities for future research and to avoid duplication of efforts and investments by the different NIH ICOs. A total of 21 NIH ICOs jointly sponsored this workshop, which occurred on September 19-20, 2019 at Natcher Conference Center, NIH in Bethesda, MD.

抗逆转录病毒疗法（ART）的成功使HIV流行的新时代迎来了新时代。艾滋病毒（PLWH）的人如果接受有效的艺术治疗，可以实现几乎正常的寿命，在这种情况下，他们更有可能遭受与定义艾滋病的疾病相比，与慢性HIV相关的合并症，共同感染和并发症（CCC）更有可能。尽管艺术取得了成功，但仍需要理解艾滋病毒的影响，其治疗以及慢性免疫激活和免疫抑制的遗产，以优化PLWH的健康状况。到目前为止，NIH的努力主要针对特定​​领域，几乎没有倡议涵盖对多器官系统或条件的影响。需要进行NIH范围的科学咨询，以更好地了解共同机制，以确定与HIV相关的CCC研究的差距和机会，并在该领域促进跨学科的合作。预计此类咨询的结果有助于促进NIH对艾滋病毒相关CCC研究需求不断增长的需求的协调响应，特别是针对未来研究的最高优先事项，并避免通过不同的NIH ICO进行努力和投资的重复。共有21个NIH ICO共同赞助了该研讨会，该研讨会于2019年9月19日至20日在马里兰州贝塞斯达NIH的Natcher会议中心举行。