SBIR FAST-TRACK AWARD (PHASE I STUDY BASE REQUIREMENT WITH OPTION FOR PHASE II STUDY) CONTINUOUS MONITORING OF ALCOHOL USE BY WEARABLE BIOSENSORS

SBIR 快速通道奖（第一阶段研究基础要求，可选择第二阶段研究）通过可穿戴生物传感器持续监测酒精使用情况

• 批准号: 10551065
• 负责人: BADAWI DWEIK
• 金额: $ 199.97万
• 依托单位: GINER, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-09 至 2023-10-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551065
• 关键词: Alcohol consumption; Alcohols; Algorithms; Award; Biological; Biosensor; Blood Tests; Blood alcohol level measurement; Breathalyzer Tests; Contracts; Development; Devices; Human; Individual; Intercellular Fluid; Measures; Methods; Mission; Monitor; National Institute on Alcohol Abuse and Alcoholism; Performance; Privatization; Recovery; Rehabilitation therapy; Research; Serum; Small Business Innovation Research Grant; Technology; Time; alcohol monitoring; alcohol response; base; commercialization; design; light weight; next generation; phase 1 study; phase 2 study; prototype; research study; sensor; wearable sensor technology

Current methods available to measure Blood Alcohol Concentration (BAC) and the biological response of alcohol in individuals are mostly limited to cumbersome breathalyzer or blood tests. The NIAAA seeks a wearable or otherwise discreet device capable of measuring, recording, and storing blood alcohol levels in real time. Alcohol biosensors that are discreet and provide continuous alcohol use monitoring will advance the mission of the NIAAA in the arenas of research, treatment, rehabilitation, and recovery. The research under this contract is toward the development of next-generation, wearable continuous alcohol monitoring (CAM) technology designed to measure, record, and store Blood Alcohol Concentration (BAC) in real time. This SBIR “Fast-Track”-type contract contains a base contract requirement for an SBIR Phase I Study and a contract option for an SBIR Phase II Study. The SBIR Phase I Study (base contract requirement) will perform analysis toward validating the technology of a new, discreet, wearable, stable, selective and highly sensitive enzymatic biosensor and algorithms that can detect alcohol in real-time and directly from interstitial fluid and evaluate its concentration in a mixture similar to human serum. The SBIR Phase II Study (contract option) will further refine and optimize the performance of the sensor probe and integrate it into a compact, lightweight prototype device ready to use in research studies that will effectively demonstrate its potential to private investors to support commercialization.

目前可用于测量血液酒精浓度（BAC）和个体中酒精的生物学反应的方法主要限于繁琐的Braathalyzer或血液检查。 NIAAA寻求可穿戴或以其他方式的谨慎装置，能够实时测量，记录和储存血液酒精水平。谨慎并提供连续饮酒监测的酒精生物传感器将在研究，治疗，康复和恢复领域推进NIAAA的任务。 该合同下的研究是为了开发下一代，可穿戴的连续酒精监测（CAM）技术，旨在实时测量，记录和储存血液酒精浓度（BAC）。该SBIR“快速轨道”型合同包含SBIR I期研究的基本合同要求，以及SBIR II期研究的合同选择。 SBIR I期研究（基本合同要求）将对验证新的，谨慎，可穿戴，稳定，选择性和高度敏感的酶生物传感器和算法的技术进行分析，该技术可以实时地检测到酒精，直接从间天间流体中检测到酒精，并在与人类血清相似的混合物中评估其浓度。 SBIR II期研究（合同选项）将进一步完善并优化传感器探测的性能，并将其整合到准备在研究中使用的紧凑，轻巧的原型设备，以有效地证明其对私人投资者支持商业化的潜力。