A Twin Study of Adolescent Alcohol and Drug Use Development: Leveraging Intensive Longitudinal Assessments

青少年酒精和药物使用发展的双重研究：利用强化纵向评估

• 批准号: 10554909
• 负责人: Naomi P. Friedman
• 金额: $ 9.93万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10554909
• 关键词: Administrative Supplement; Adolescent; Affect; Affective; Anxiety; Area; Behavior; Behavior Therapy; Behavioral; COVID-19; COVID-19 pandemic; COVID-19 pandemic effects; Clinical Trials; Complex; Data; Data Collection; Data Set; Depressed mood; Development; Drug Addiction; Drug usage; Environment; Etiology; Foundations; Funding; Future; Grant; Health behavior; Human; Individual; Intervention; Location; Metadata; Methods; Modeling; Nature; Parents; Patient Self-Report; Pattern; Policies; Research; Research Personnel; Telephone; Testing; Time; Travel; Twin Multiple Birth; Twin Studies; U-Series Cooperative Agreements; United States National Institutes of Health; Work; adolescent alcohol and drug use; analytical method; base; cohort; coronavirus disease; design; drug development; experience; interest; mHealth; member; novel; pandemic disease; parent project; response; secondary analysis; substance use; theories; time use

ABSTRACT This is a response to PA-18-591: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional). This parent project is part of the Intensive Longitudinal Health Behaviors Network (ILHBN) established to collaboratively study factors that influence dynamic health behaviors in individuals’ daily lives, using intensive longitudinal data (ILD) collection and novel analytic methods. The network includes seven U01 projects and one U24 Research Coordinating Center (RCC). This specific project leverages ILD in a genetically informative design to understand the development of affect, mobility, and drug use in the context of the COVID-19 pandemic. Evidence suggests that the experience of the COVID pandemic has caused increases in depressed mood and anxiety. These, in turn, have implications for other health behaviors, such as substance use behaviors. Using intensive longitudinal data, we will evaluate the nature and etiology of how individuals’ self-report affective dynamics and mobility patterns vary over time, using phone-based location data to infer individuals’ activity space (typical area traveled for routine everyday activities) as well as local covid conditions (e.g., case counts, lockdown policy) related to COVID. We will test whether changes in local covid conditions are associated with each other and with changes in affect, mobility, and substance use. Data from the parent project will be shared with the ILHBN Research Coordinating Center to facilitate scientific efforts in other ILHBN studies.

抽象的 这是对PA-18-591的回应：对现有NIH赠款和合作社的行政补充 协议（母公司临床试验可选）。这个父项目是密集型的一部分 建立了纵向健康行为网络（ILHBN），以研究影响影响的因素 使用密集的纵向数据（ILD）收集和新颖的个人日常生活中的动态健康行为 分析方法。该网络包括七个U01项目和一个U24研究协调中心 （RCC）。这个特定的项目以一般有益的设计利用ILD来了解 在COVID-19大流行的背景下，影响，活动性和药物使用。证据表明经验 在互联的大流行中，情绪低落和动画导致了抑郁症。反过 对其他健康行为的影响，例如药物使用行为。使用密集的纵向数据，我们 将评估个人自我报告情感动态和流动模式的性质和病因 随着时间的流逝而有所不同，使用基于电话的位置数据推断个人的活动空间（典型的区域旅行 每天的日常活动）以及与当地的互联条件（例如，案件计数，锁定政策） 冠状病毒。我们将测试本地互联条件的变化是否相互关联，并与 影响，流动性和物质使用的变化。父母项目的数据将与ILHBN共享 研究协调中心，以促进其他ILHBN研究中的科学努力。

项目成果

Computing the real solutions of Fleishman's equations for simulating non-normal data.

计算弗莱什曼方程的实数解以模拟非正态数据。

• DOI: 10.1111/bmsp.12259
• 发表时间: 2022
• 期刊: The British journal of mathematical and statistical psychology
• 作者: Helwig,NathanielE