Neuronal and behavioral effects of an implicit priming approach to improve eating behaviors in obesity

隐式启动方法改善肥胖饮食行为的神经元和行为效应

• 批准号: 10551293
• 负责人: JASON R TREGELLAS
• 金额: $ 52.82万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-09 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10551293
• 关键词: Acute; Affective; Association Learning; Attention; Attitude; Behavior; Behavioral; Body Composition; Body Weight decreased; Brain; Calories; Chronic; Cognitive; Complex; Consumption; Cues; Data; Desire for food; Eating; Eating Behavior; Emotional; Energy Intake; Fatty acid glycerol esters; Food; Food Preferences; Funding; Goals; Health; Hormones; Ice Cream; Image; Individual; Insula of Reil; Intake; Intervention; Investigation; Learning; Maggots; Maintenance; Measures; Negative Valence; Neurobiology; Neurons; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Participant; Patient Self-Report; Perception; Pilot Projects; Positive Valence; Predisposition; Prefrontal Cortex; Process; Property; Public Health; Quality of life; Radio; Randomized; Regulation; Research; Rewards; Risk; Risk Factors; Sensory; Signal Transduction; Stimulus; Strategic Planning; United States National Institutes of Health; Ventral Striatum; Visual; Washington; Weight; Woman; active control; behavior change; behavior measurement; behavioral response; behavioral study; cardiovascular disorder risk; conditioning; design; energy balance; food craving; hedonic; improved; intervention effect; men; mortality; neuroimaging; novel; obesity prevention; preference; prevent; recruit; response; sex; therapy design; weight loss program; weight maintenance

PROJECT SUMMARY/ABSTRACT Weight loss is associated with a reduction in obesity-related health risks, but can be difficult, with preventing subsequent weight regain even more challenging. As such, understanding mechanisms underlying energy balance regulation and identifying strategies for successful weight loss and maintenance are important goals, and are key components of the Strategic Plan for NIH Obesity Research. Food intake is a complex process involving homeostatic signals (e.g., appetite-related hormones) and non-homeostatic signals (e.g., reinforcing properties of food). One factor that may contribute to susceptibility to obesity is a high responsivity to high-calorie foods, which promotes increased caloric intake. Food preferences involve learned associations thought to develop via classical conditioning through repeated pairings with external stimuli. Improving our understanding of the neuronal mechanisms underlying these processes and attempting to modify them may be a useful strategy for weight loss and maintenance. Therefore, the proposed study aims to investigate the neuronal and behavioral effects of an intervention designed to alter affective associations with food, using a novel implicit priming (IP) paradigm, in which positively or negatively valenced images are presented immediately prior to food images, but not consciously perceived. We hypothesize that IP will alter neuronal and behavioral responses related to food intake, reducing the appeal of high-calorie foods and promoting weight loss and maintenance. The project goals are to further delineate the neuronal mechanisms underlying the intervention, establish the impact of IP on longer-term food preferences and eating behavior, and determine if it can facilitate weight- loss maintenance in individuals with overweight/obesity. Effects of IP on neuronal responses to visual food cues and measures of eating behaviors (food intake, preferences) will be measured not only acutely, but also following 12 weeks of weekly IP administrations, within the context of weight-loss maintenance. Weight and body composition will be measured before and after the intervention, and, to assess lasting effects, 12 weeks after the intervention has ended. Participants will be randomized to active IP, control IP (with scrambled images as primes), or to an active control, cue exposure therapy (CET). Sex-based differences will also be examined, as studies have observed women to have stronger, more frequent food cravings, greater neuronal response to hedonic food cues, and greater sensitivity to disgust than men. The use of neuroimaging in this study will provide a more sensitive measure than behavioral measures alone and will help to identify mechanisms through which the intervention changes behavior. If the project aims are achieved, it would not only yield new information about the neurobiology of food intake behavior, but also could represent a potential novel intervention for treatment and prevention of obesity.

项目摘要/摘要 减肥与肥胖相关的健康风险的降低有关，但可能很困难，防止 随后的体重更加具有挑战性。因此，了解能量的基础机制 平衡监管和确定成功减肥和维护的策略是重要的目标， 这是NIH肥胖研究战略计划的关键组成部分。 食物摄入量是一个复杂的过程，涉及稳态信号（例如，与食欲相关的激素）和 非固定信号（例如，食物的增强特性）。可能导致对易感性的一个因素 肥胖是对高热量食品的高度反应，可促进热量摄入量增加。食物偏好 涉及学到的联想通过与重复配对一起通过经典调节发展的关联 外部刺激。提高我们对这些过程的神经元机制的理解和 尝试修改它们可能是减肥和维护的有用策略。因此，提议 研究旨在研究旨在改变情感的干预措施的神经元和行为影响 使用新型隐式启动（IP）范式的食物相关联 图像是在食品图像之前立即呈现的，但没有有意识地感知。我们假设IP 将改变与食物摄入有关的神经元和行为反应，从而降低高热量食品的吸引力 并促进减肥和维护。 项目目标是进一步描述干预措施的神经元机制，建立 IP对长期食品偏好和饮食行为的影响，并确定它是否可以促进体重 超重/肥胖的人的损失维持。 IP对神经元反应对视觉食品的影响 饮食行为的提示和衡量标准（食物摄入，偏好）将不仅敏锐地衡量，还可以衡量 在每周减肥维护的背景下，每周12周的IP管理。重量和 身体成分将在干预之前和之后测量，并评估持久的影响，12周 干预结束后。参与者将被随机分配到主动IP，控制IP（使用扰动 图像作为素数）或主动控制，提示暴露疗法（CET）。基于性别的差异也将是 被检查，因为研究观察到妇女的食物更加强烈，更频繁，神经元更大 对享乐食品提示的反应，对男性的敏感性更大。在此中使用神经影像 研究将提供比仅行为措施更敏感的措施，并有助于识别 干预改变行为的机制。如果实现了项目的目标，那将不会 仅产生有关食物摄入行为神经生物学的新信息，但也可以代表潜力 用于治疗和预防肥胖症的新干预。