COBRE Center for Neuromodulation (CCN)

COBRE 神经调节中心 (CCN)

• 批准号: 10548168
• 负责人: BENJAMIN D GREENBERG
• 金额: $ 198.05万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10548168
• 关键词: Address; Area; Award; Behavior; Behavioral; Brain; Brain Diseases; Career Mobility; Centers of Research Excellence; Cephalic; Clinical; Clinical Psychology; Clinical Research; Clinical Trials; Collaborations; Communities; Consultations; Data; Data Analytics; Development; Diagnosis; Dimensions; Disease; Electric Stimulation; Engineering; Equipment; Evaluation; Experimental Designs; Extinction; Fright; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Grant; Growth; Hospitals; Impairment; Impulsive Behavior; Impulsivity; Infrastructure; Investigation; Learning; Link; Magnetism; Measures; Memory; Mentors; Mentorship; Methodology; Methods; Modeling; Monitor; Neuropsychology; Obsessive-Compulsive Disorder; Outcome; Patients; Persons; Pharmacological Treatment; Pilot Projects; Population; Post-Traumatic Stress Disorders; Protocols documentation; Research; Research Personnel; Resources; Rhode Island; Safety; Scientist; Structure; Symptoms; Talents; Technical Expertise; Testing; Translational Research; Universities; Work; brain based; brain research; career; career development; clinical application; clinical efficacy; clinical implementation; clinical translation; clinically relevant; cognitive neuroscience; data acquisition; design; experience; innovation; insight; interest; medical schools; multidisciplinary; neural circuit; neuroimaging; neuropsychiatric disorder; neuropsychiatry; neuroregulation; noninvasive brain stimulation; novel; programs; recruit; skill acquisition; skills; synergism; tool; translational medicine; years lived with disability; young adult

PROJECT SUMMARY The COBRE Center for Neuromodulation (CCN) will be centered at Butler Hospital, a freestanding psychiatric and neuropsychiatric hospital affiliated with the Alpert Medical School at Brown University. This COBRE will create key infrastructure and support a core group of interdisciplinary investigators to build a self-sustaining center of excellence in clinical-translational brain research. Its overall goal is to advance the use of noninvasive neuromodulation in circuit-based therapies for neuropsychiatric disorders. This application brings together three highly promising junior investigators, who will use methods of noninvasive brain stimulation (transcranial magnetic and transcranial electrical stimulation) and neuroimaging tools (structural and functional MRI). They will work together on clinical-translational research on brain circuits relating to symptoms and dimensions of illness. Their areas of interest are impulsive behavior, PTSD, and obsessive-compulsive disorder (OCD). Using experienced, highly skilled mentors working within the structure of an Administrative Core, the CCN will advance the careers of these talented young researchers towards the next level of research independence. The CCN will support two new research cores: the Design and Analysis Core (DAC) and the Neuroimaging and Neuromodulation Core (NNC) at Butler Hospital. These cores will provide essential infrastructure needed to successfully carry out each project. This includes statistical and methodological consultation and expertise needed to design and analyze the studies proposed (DAC), and equipment, technical support, and expertise necessary for stimulation implementation and acquisition of neuroimaging data (NNC). The Administrative Core will also support pilot grants relating to our theme of translational research in neural circuits and disease. These grants will be awarded yearly in years 2 to 5 of the Center. The CCN will establish Butler Hospital as a national leader in this exciting field of translational medicine, which will expand research and clinical application of noninvasive brain stimulation across disorders of brain and behavior. It will unify an interdisciplinary community in clinical-translational research of neuropsychiatric illness, for the ultimate benefit of patients.

项目摘要 神经调节的鞋垫中心（CCN）将以独立的精神病医院为中心 布朗大学的Alpert医学院隶属于神经精神病医院。这个毛绒会 创建关键的基础架构并支持跨学科研究人员的核心群体，以建立自我维持 临床翻译大脑研究卓越中心。它的总体目标是提高无创的使用 基于电路的神经精神疾病疗法的神经调节。 该应用程序汇集了三位高度有前途的初级调查人员，他们将使用 无创脑刺激（经颅磁和经颅电刺激）和神经成像 工具（结构和功能性MRI）。他们将共同研究有关脑电路的临床翻译研究 与疾病的症状和维度有关。他们感兴趣的领域是冲动行为，PTSD和 强迫症（OCD）。使用经验丰富的高技能导师在结构中工作 在行政核心中，CCN将使这些才华横溢的年轻研究人员的职业发展 下一个研究独立性。 CCN将支持两个新的研究核心：设计和分析核心（DAC）和神经影像学 和巴特勒医院的神经调节核心（NNC）。这些核心将提供必需的基础设施 成功执行每个项目。这包括统计和方法学咨询以及专业知识 需要设计和分析拟议的研究（DAC），设备，技术支持和专业知识 刺激和获取神经影像数据（NNC）所必需的。 行政核心还将支持与我们的神经转化研究主题有关的飞行员赠款 电路和疾病。这些赠款将在该中心的2至5年度每年授予。 CCN将在这个令人兴奋的转化医学领域建立巴特勒医院，成为国家领导者 将扩大跨大脑疾病的无创大脑刺激的研究和临床应用 行为。它将在神经精神疾病的临床翻译研究中统一一个跨学科的社区， 为患者的最终好处。