Research Training in Natural Product Complementary and Integrative Health

天然产品补充和综合健康研究培训

• 批准号: 10543771
• 负责人: JIMMY ORJALA
• 金额: $ 12.29万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10543771
• 关键词: Complementary Health; Integrative Medicine; Natural Products; Research Training

Project Summary/Abstract Of the >100 pharmacy colleges in the U.S., the University of Illinois at Chicago (UIC) College of Pharmacy is the third oldest, founded in 1859, and is even older than the University of Illinois itself. The UIC College of Pharmacy consistently ranks in the top five nationally for overall research expenditures by AACP and for NIH funding. Enrolling an average of 120 graduate students at any one time, this renewal application seeks support for our most prestigious program in natural products research and graduate education: the Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS), which was founded by the late Prof. Norman Farnsworth. PCRPS has a global reputation of excellence in graduate education and postgraduate training, with hundreds of alumni worldwide. The signature of this program is its emphasis on interdisciplinary and collaborative approaches to graduate education in natural products of biomedical relevance. The PCRPS incorporates our Pharmacognosy graduate program, one of just two such programs in the U.S., a postdoctoral and scholarly training and exchange program in Pharmacognosy including the UIC WHO Traditional Medicines Collaborating Center, and Medicinal Chemistry graduate and postgraduate training with a natural products focus. Since 1999, the UIC College of Pharmacy is also home to the UIC/NIH Center for Botanical Dietary Supplements Research, which is the oldest NIH-supported Botanical Center. Directed by the PI, Dr. Pauli, the UIC Botanical Center evaluates the safety and efficacy of botanical dietary supplements that are used widely by menopausal women in the U.S. With approximately 50 PhD graduates so far, this Center has been a major focus of graduate education in natural products research. The recently established Center for Natural Product Technologies (CeNAPT) has further expanded this educational opportunities for our trainees. Mentored by a large group of well-funded faculty with expertise in natural products research, our graduates move on to leadership positions in academia, industry, regulatory, and government here in the U.S. and all over the world. Training young scientists for careers in natural products research is a core mission of our College of Pharmacy, the PCRPS, and the Botanical and CeNAPT Centers, and the focus of this training grant.

项目摘要/摘要 在美国的> 100所药房学院，伊利诺伊大学芝加哥大学（UIC）学院 药房是第三大的，成立于1859年，甚至比伊利诺伊大学大 本身。 UIC药学院在全国范围内始终在全国排名前五名 AACP和NIH资助的研究支出。平均注册120个毕业生 该续签申请在任何时候都为我们最负盛名的人提供支持 天然产品研究和研究生教育计划：合作计划 药物科学（PCRP）的研究是由已故教授创立的。 诺曼·法恩斯沃思。 PCRP在研究生教育方面拥有卓越的全球声誉， 研究生培训，全世界有数百名校友。该程序的签名是 强调自然研究生教育的跨学科和协作方法 生物医学相关性的产物。 PCRP纳入了我们的药学毕业生 计划，是美国仅有的两个这样的计划之一，一种博士后和学术培训， 药物的交换计划，包括传统药物的UIC 合作中心和药物化学毕业生和研究生培训 天然产品聚焦。自1999年以来，UIC药学院也是UIC/NIH的家园 植物饮食补充剂研究中心是最古老的NIH支持的 植物中心。 UIC植物中心由PI指导的Pauli博士评估了安全性 以及植物饮食补充剂的功效，在绝经中广泛使用 到目前为止，美国有大约50名博士学位毕业生，该中心一直是 天然产品研究研究生教育。最近建立的自然中心 产品技术（CENAPT）进一步扩大了我们的教育机会 学员。由一大批资金丰富的教师指导，具有天然产品的专业知识 研究，我们的毕业生继续担任学术界，行业，监管和 美国和世界各地的政府。培训年轻科学家的职业 天然产品研究是我们药学学院，PCRP和 植物和cenapt中心，以及这项培训补助金的重点。

项目成果

Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling.

• DOI: 10.1016/j.canlet.2017.01.011
• 发表时间: 2017-04-10
• 期刊: Cancer letters
• 影响因子: 9.7
• 作者: Dean M;Davis DA;Burdette JE
• 通讯作者: Burdette JE

Holistic Analysis Enhances the Description of Metabolic Complexity in Dietary Natural Products.

整体分析增强了对膳食天然产物代谢复杂性的描述。

• DOI: 10.3945/an.115.009928
• 发表时间: 2016
• 期刊: Advances in nutrition (Bethesda, Md.)
• 作者: Simmler,Charlotte;Kulakowski,Daniel;Lankin,DavidC;McAlpine,JamesB;Chen,Shao-Nong;Pauli,GuidoF
• 通讯作者: Pauli,GuidoF

Metabolomics of bacterial-fungal pairwise interactions reveal conserved molecular mechanisms.

细菌-真菌配对相互作用的代谢组学揭示了保守的分子机制。

• DOI: 10.1039/d3an00408b
• 发表时间: 2023
• 期刊: The Analyst
• 作者: Luu,GordonT;Little,JessicaC;Pierce,EmilyC;Morin,Manon;Ertekin,CelineA;Wolfe,BenjaminE;Baars,Oliver;Dutton,RachelJ;Sanchez,LauraM
• 通讯作者: Sanchez,LauraM

Secoiridoids from Dogwood (Cornus officinalis) Potentiate Progesterone Signaling.

• DOI: 10.1021/acs.jnatprod.1c00516
• 发表时间: 2021-09-24
• 期刊: Journal of natural products
• 影响因子: 5.1
• 作者: Lee JH;Austin JR;Burdette JE;Murphy BT
• 通讯作者: Murphy BT

Diazaquinomycins E-G, novel diaza-anthracene analogs from a marine-derived Streptomyces sp.

• DOI: 10.3390/md12063574
• 发表时间: 2014-06-11
• 期刊: Marine drugs
• 影响因子: 5.4
• 作者: Mullowney MW;Ó hAinmhire E;Shaikh A;Wei X;Tanouye U;Santarsiero BD;Burdette JE;Murphy BT
• 通讯作者: Murphy BT