Host Response to Trauma Research Training Program

主持人对创伤研究培训计划的反应

• 批准号: 10542993
• 负责人: Alex B. Lentsch
• 金额: $ 33.14万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10542993
• 关键词: Immune response; Training Programs; Trauma Research

Abstract Trauma is the most common cause of death in people under the age of 45 in the United States and costs more than $400 billion annually for medical care and lost productivity. The demand for trauma and surgical critical care workforce in the US has never been higher and a severe shortage of surgeons in this field is looming. The need for academic trauma and critical care practitioners that can not only treat patients, but have the necessary skills to conduct basic, translational, and clinical research to advance our knowledge and develop new treatments is even greater. The fundamental purpose of this training program is to provide surgical residents and pediatric critical care medicine fellows with an intensive two-year research training experience that will prepare them for an academic career in trauma and critical care. Our training program has evolved over the past 29 years into a highly structured and collaborative program that involves participants from multiple clinical and basic science disciplines. Our trainees benefit from a team-based mentorship philosophy, outstanding institutional support, and a broad range of educational opportunities. The training program is designed to teach surgical residents, pediatric critical care fellows, and conventional PhD postdoctoral fellows to assess a trauma-related problem, identify the key questions, formulate hypotheses, and then design and conduct the appropriate experiments to test the hypotheses and answer the questions.

抽象的 创伤是美国45岁以下人群中最常见的死亡原因， 每年用于医疗服务和生产力损失的费用超过4000亿美元。对创伤的需求 美国的手术重症监护劳动力从未如此高，严重短缺 该领域的外科医生迫在眉睫。对学术创伤和重症监护从业人员的需求 不仅可以治疗患者，而且具有进行基本，翻译和临床的必要技能 促进我们的知识和发展新疗法的研究更大。基本 该培训计划的目的是提供手术居民和小儿重症监护医学 具有深厚为期两年的研究培训经验的研究员，将为学术做好准备 创伤和重症监护职业。在过去的29年中，我们的培训计划已发展为 高度结构化和协作计划，涉及来自多个临床和基本的参与者 科学学科。我们的学员受益于基于团队的指导理念，杰出 机构支持和广泛的教育机会。培训计划是 旨在教手术居民，小儿重症监护研究员和常规博士学位 博士后研究员评估与创伤有关的问题，确定关键问题，制定 假设，然后设计和进行适当的实验以检验假设和 回答问题。

项目成果

A novel role for matrix metalloproteinase-8 in sepsis.

• DOI: 10.1097/ccm.0b013e318232e404
• 发表时间: 2012-02
• 期刊: Critical care medicine
• 影响因子: 8.8
• 作者: Solan PD;Dunsmore KE;Denenberg AG;Odoms K;Zingarelli B;Wong HR
• 通讯作者: Wong HR

Improving packed red blood cell storage with a high-viscosity buffered storage solution.

• DOI: 10.1016/j.surg.2021.11.020
• 发表时间: 2022-03
• 期刊: Surgery
• 影响因子: 3.8
• 作者: Pulliam KE;Joseph B;Makley AT;Caldwell CC;Lentsch AB;Goodman MD;Pritts TA
• 通讯作者: Pritts TA

Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis.

• DOI: 10.1097/pcc.0b013e31824fbd90
• 发表时间: 2012-09
• 期刊: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
• 作者: Nowak JE;Harmon K;Caldwell CC;Wong HR
• 通讯作者: Wong HR

Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis.

• DOI: 10.1371/journal.pone.0112702
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Atkinson SJ;Cvijanovich NZ;Thomas NJ;Allen GL;Anas N;Bigham MT;Hall M;Freishtat RJ;Sen A;Meyer K;Checchia PA;Shanley TP;Nowak J;Quasney M;Weiss SL;Banschbach S;Beckman E;Howard K;Frank E;Harmon K;Lahni P;Lindsell CJ;Wong HR
• 通讯作者: Wong HR

Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis.

• DOI: 10.1097/ccm.0000000000001374
• 发表时间: 2016-04
• 期刊: Critical care medicine
• 影响因子: 8.8
• 作者: Atkinson SJ;Nolan M;Klingbeil L;Harmon K;Lahni P;Zingarelli B;Wong HR
• 通讯作者: Wong HR