Therapeutic interventions for post-stroke rehabilitation

中风后康复的治疗干预

基本信息

批准号：
10542336
负责人：
Helen M Bramlett
金额：
--
依托单位：
MIAMI VA HEALTH CARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-11-01 至 2025-10-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10542336
关键词：
Acute Adoptive Transfer Affect Animal Model Body Weight decreased Brain Brain hemorrhage Caring Cause of Death Cerebral Ischemia Clinic Clinical Clinical Trials Cognition Cognitive Communication Communities Data Deterioration Exercise Fatigue Female Fingerprint Frequencies Future Gait speed Genes Goals Hippocampus (Brain)Home Hormones Human Impaired cognition Infarction Inflammation Inflammatory Intervention Ischemic Brain Injury Ischemic Stroke Laboratories Laboratory Animals Link Mechanics Mediating Middle Cerebral Artery Occlusion Mitochondria Modeling Monitor Muscle Neurons Outcome Patients Physical Exercise Physical activity Physiological Pilot Projects Play Proteomics Quality of life Rattus Recovery Research Role Serum Skeleton Stroke Stroke prevention Temperature Testing Therapeutic Therapeutic Effect Therapeutic Intervention Tissues Transient Ischemic Attack Translating Treatment Efficacy United States Department of Veterans Affairs Vesicle Veterans Veterans Health Administration aged base behavioral study cost cytokine disability efficacy testing extracellular vesicles frailty glucose metabolism hormone therapy improved in vivo indexing insight middle age mitochondrial dysfunction mortality motor deficit motor learning natural hypothermia neurobehavior neuroinflammation neuronal survival novel novel therapeutic intervention out-of-hospital cardiac arrest post stroke post stroke cognitive impairment preclinical study response sex spinal cord and brain injury stroke model stroke outcome stroke patient stroke rehabilitation stroke risk stroke survivor thrombolysis transcriptional reprogramming transcriptomics translational goal vibration

项目摘要

Stroke remains one of the leading causes of death and disability in the USA. The principal objective of the current proposal is to test the efficacy of combined therapeutic hypothermia with whole body vibration on post-stroke cognitive improvement using a model of stroke in aged rats. There are three main types of stroke: transient ischemic attack, hemorrhagic stroke and acute ischemic stroke, with the latter constituting 87% of total stroke cases. Currently, the only clinical therapies available for acute ischemic stroke are thrombolysis (tPA) and mechanical endovascular recanalization, both of which have only limited applications in a small number of patients. Cognitive decline is one of the most significant problems affecting almost two-thirds of stroke survivors for up to 6 years post-stroke. Therefore, identifying novel neuroprotective strategies to improve post-stroke cognition remains a high priority. In animal models of stroke (transient middle cerebral artery occlusion – tMCAO), behavioral studies yield evidence of deficits in spatial, non-spatial, and motor learning. These deficits can be minimized in middle-aged rat models of stroke with noninvasive whole body vibration (WBV) therapy. Likewise, long-standing research from our laboratory shows that therapeutic hypothermia (TH) is a potent neuroprotective therapy in experimental cerebral ischemia with multiple effects at several stages of the ischemic cascade. The translational goal of our successful study will be to identify a novel therapeutic approach for stroke rehabilitation that can be moved quickly to testing in clinical trials.

中风仍然是美国死亡和残疾的主要原因之一。的主要目标当前的建议是测试与全身振动的联合治疗性体温过低的效率使用年龄大鼠的中风模型的中风后认知改善。有三种主要类型的中风：短暂性缺血发作，出血性中风和急性缺血性中风，后者构成占中风总案例的87％。目前，唯一可用于急性缺血性中风的临床疗法是溶栓（TPA）和机械内血管内再通电，两者仅限于在少数患者中的应用。认知能力下降是最重要的问题之一在击球后长达6年，影响了近三分之二的中风生存。因此，识别小说改善后击后认知的神经保护策略仍然是一个很高的优先事项。在动物模型中中风（瞬时脑动脉闭塞 - TMCAO），行为研究产生缺陷的证据在空间，非空间和运动学习中。这些定义可以在中年大鼠模型中最小化无创全身振动（WBV）治疗的中风。同样，长期研究从我们的实验室表明，治疗性低温（Th）是一种潜在的神经保护疗法实验性脑缺血在缺血性级联的几个阶段具有多种作用。我们成功研究的翻译目标将是确定一种新型的中风治疗方法可以在临床试验中迅速转移到测试的康复。