2022 Conference: Clinical and Scientific Advances in Urinary Tract Infections

2022 年会议：尿路感染的临床和科学进展

• 批准号: 10540602
• 负责人: Christina B Ching
• 金额: $ 0.25万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540602
• 关键词: Acute; Adult; Antibiotic Resistance; Antibiotic Therapy; Antibiotics; Area; Bacterial Antibiotic Resistance; Basic Science; Buffaloes; Caring; Characteristics; Child; Childhood; Clinical; Clinical Management; Clinical Pathology; Clinical Research; Collaborations; Communicable Diseases; Complex; Diagnosis; Discipline; Discipline of Nursing; Discipline of obstetrics; Disease; Doctor of Philosophy; Elderly; Emergency Medicine; Emergency department visit; End stage renal failure; Ensure; Faculty; Fostering; Future; Geriatrics; Government Agencies; Health; Hospitalization; Human; Hypersensitivity; Hypertension; Immunology; Industrialization; Infection; Institutes; International; Investments; Justice; Lead; Low Birth Weight Infant; Medical; Medicine; Microbiology; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; New York; Ohio; Outcome; Outpatients; Pathogenesis; Patients; Pediatrics; Physician Executives; Practice Management; Predisposition; Pregnancy; Premature Birth; Prevention; Principal Investigator; Queensland; Recovery; Recurrence; Research; Research Personnel; Science; Scientific Advances and Accomplishments; Scientific Inquiry; Scientist; Secure; Sepsis; Series; Sex Differences; Therapeutic; Training; Underrepresented Populations; United States; Universities; Urinary tract; Urinary tract infection; Urologic Diseases; Urology; Visit; Washington; Woman; adverse pregnancy outcome; age difference; alternative treatment; base; bench to bedside; beta-Lactams; biomedical scientist; career; catheter associated UTI; clinical conference; clinical practice; clinically relevant; comorbidity; disability; insight; interest; medical schools; medical specialties; meetings; mental state; mid-career faculty; mortality; multidisciplinary; next generation; novel diagnostics; novel therapeutic intervention; patient population; prevent; professor; recruit; renal scarring; side effect; socioeconomics; symposium; trait; translational approach; translational health science

ABSTRACT Urinary tract infections are a significant socioeconomic burden afflicting 150 million patients worldwide each year, most of whom are healthy adult women. The high rate of antibiotic usage to treat acute and recurrent episodes of urinary tract infection has led to a dramatic increase in the number of infections caused by antibiotic resistant bacteria including extended spectrum beta- lactam producing strains. The decrease in availability of efficacious antibiotic therapies has elevated the need to accelerate all aspects of UTI research as outlined in our programmatic topic areas. This conference goes beyond the exchange of basic science findings and strive for a clinical relevance of research findings as they can be applied to clinical practice as well as using clinical challenges to foster new collaborations and experimental approaches. Although healthy women represent the majority of patients treated for urinary tract infection, we will target previously under investigated areas such as sex and age differences, susceptibility factors and negative sequelae. Further, this conference provides clinicians across specialties (such as pediatrics, geriatrics, obstetrics, complex care, emergency medicine, urology, and nephrology) the opportunity to brainstorm treatment approaches with each other and to communicate their needs for research directly to researchers, informing future lines of scientific inquiry. By focusing holistically on the disease of UTI rather than on any one research or clinical approach, discussions and collaborations can cross from the bench to the bedside. As part of a long-term plan for preventing and managing UTI, we also have a training mission to recruit and support early career researchers and those not traditionally represented in medicine and research as they transition into the next generations of experts.

抽象的 泌尿道感染是一种重大的社会经济负担，折磨了1.5亿患者 每年在全球范围内，其中大多数都是健康的成年女性。抗生素使用率高于 治疗泌尿道感染的急性和复发性发作导致该急性的急性增加 由抗生素抗性细菌引起的感染数量，包括扩展光谱β- 乳糖产生菌株。有效抗生素疗法的可用性减少已升高 需要在我们的编程主题领域中概述的UTI研究的各个方面加速。 这次会议超出了基础科学发现的交换，而是努力争取临床 研究结果的相关性可以应用于临床实践以及使用临床 培养新的合作和实验方法的挑战。虽然健康的女性 代表大多数因尿路感染治疗的患者 研究了性别和年龄差异，易感因素和负后遗症等领域。 此外，这次会议为跨专业提供了临床医生（例如儿科，老年医学， 产科，复杂的护理，急诊医学，泌尿科和肾脏科） 集思广益治疗方法彼此并传达其研究需求 直接向研究人员通知未来的科学探究路线。通过整体关注 UTI疾病，而不是任何一种研究或临床方法，讨论和合作 可以从长凳到床边越过。作为预防和管理的长期计划的一部分 UTI，我们还具有培训使命，以招募和支持早期职业研究人员，而那些没有 传统上在医学和研究中代表他们过渡到下一代 专家。