Capacity Building for Neurodevelopmental Research on Maya Children’s Language Environment

玛雅儿童语言环境神经发育研究的能力建设

• 批准号: 10538858
• 负责人: Laura M. Justice
• 金额: $ 17.86万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-23 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10538858
• 关键词: 3 year old; Address; Adult; Area; Brain; Brain region; Buffers; Caregiver well-being; Caregivers; Child; Child Development; Child Language; Chronic; Competence; Country; Data; Data Analyses; Database Management Systems; Development; Disease; Educational workshop; Enrollment; Environment; Exposure to; Family; Fostering; Foundations; Funding; Growth; Health; Home; Home environment; Household; Income; Indigenous; Intervention; Language; Language Development; Language Disorders; Lead; Longevity; Longitudinal Studies; Maintenance; Malnutrition; Measures; Methods; Mexico; Modeling; Monitor; Nature; Neurodevelopmental Disorder; Parent-Child Relations; Patient Recruitments; Personal Satisfaction; Pilot Projects; Population; Poverty; Prevalence; Questionnaires; Reporting; Research; Research Activity; Research Design; Research Ethics; Research Project Grants; Risk; Role; Rural; Structure; Testing; Time; Training; Vision; Work; base; behavior measurement; caregiving; design; educational atmosphere; experience; human subject protection; improved; indexing; interest; literacy; member; nervous system disorder; neurodevelopment; prevent; programs; screening; skills; tool

Project Summary This Exploratory/Developmental Research Grant will provide support for `global brain and nervous system disorders research across the lifespan' via two foci: (1) developing foundations for sustainable neuro- health research capacity in Mexico's Yucatán state focused on the early years of brain development for Yucatec Maya children, and (2) improving understanding of influences on Yucatec Maya children's early language trajectories. Specific Aim 1 is to improve local research capacity at the Mexico-based Solyluna A.C. to plan, conduct, and disseminate research on language-specific neurodevelopmental function and disorders among Yucatec Maya children. Specific Aim 2 is to conduct a pilot longitudinal study of the home environment and its influence on Yucatec Maya children's early language trajectories. For the latter, we use behavioral measures of Spanish and Mayan language skill, which serve to approximate the cortical structure and function of language-supporting brain regions. To address Aim 1, we engage in two-years of activities designed to develop the research capabilities of the Solyluna-based team in eight areas: (1) research ethics and human-subject protections, (2) participant recruitment, screening, enrollment, and maintenance; (3) implementation of child language assessments in Mayan and Spanish with integrity, (4) development, piloting, and implementation of caregiver questionnaires, (5) implementation of observational tools to measure the home environment, (6) data-entry, cleaning, and database management, (7) data analyses and interpretation, and (8) dissemination. These competencies will be explicitly addressed in six capacity-building workshops and aligned data-analysis working sessions. The OSU-based team and expert consultants have expertise in all eight areas and also bring substantive experience aligned to the longitudinal pilot study. To address Aim 2, we design, implement, and disseminate a longitudinal pilot study involving 100 3- year-old Yucatec Maya children and their caregivers. Dyads will participate in study activities over an 18-month period. Tentatively, we expect to collect a comprehensive caregiver questionnaire at baseline and child language assessments and home observations at 4 time-points with roughly 4- to 5-month intervals. Home observations include activities designed to measure caregiver well-being, household hardship, parent-child interaction quality, and exposure to child-directed talk. Multilevel growth-curve models will be used to investigate the language trajectories for children captured at four time-points and to examine the contribution of the home-environment indices to these trajectories.

项目摘要 这项探索性/发展研究赠款将为“全球大脑和紧张 通过两个焦点进行整个寿命的系统疾病研究：（1）开发可持续神经的基础 墨西哥尤卡坦州的卫生研究能力着重于大脑发育的早期几年 Yucatec Maya儿童，以及（2）提高对Yucatec Maya儿童早期影响的理解 语言轨迹。具体目的1是提高位于墨西哥的Solyluna A.C.的本地研究能力。 计划，进行和传播有关语言特定神经发育功能和疾病的研究 在Yucatec Maya的儿童中。具体目标2是对家庭环境进行试验纵向研究 以及它对尤卡特玛雅儿童早期语言轨迹的影响。对于后者，我们使用行为 西班牙语和玛雅语言技能的度量，可用于近似皮质结构和功能 支持语言的大脑区域。 为了解决目标1，我们从事旨在发展研究能力的两年活动 八个领域的基于Solyluna的团队：（1）研究伦理和人类受试者保护，（2）参与者 招聘，筛查，入学和维护； （3）实施儿童语言评估 玛雅和西班牙的正直，（4）照顾者问卷的开发，驾驶和实施， （5）实施观察工具来测量家庭环境，（6）数据输入，清洁和 数据库管理，（7）数据分析和解释以及（8）传播。这些能力将 在六个能力构建研讨会和对齐数据分析工作会议中明确解决。这 基于OSU的团队和专家顾问在所有八个领域都有专家，还带来实质性的 与纵向试点研究保持一致的经验。 为了解决AIM 2，我们设计，实施和传播了涉及100 3-的纵向试点研究 一岁的Yucatec Maya儿童及其护理人员。二元组将参加18个月的学习活动 时期。暂时，我们希望在基线和孩子们收集一份全面的护理人员问卷 大约4到5个月间隔的4个时间点的语言评估和家庭观察。家 观察包括旨在衡量护理人员福祉，家庭困难，亲子的活动 互动质量，并接触到儿童指导的谈话。多级生长曲线模型将用于 调查以四个时间点捕获的儿童的语言轨迹，并检查 这些轨迹的家庭环境指数。