LSUHSC-NO Comprehensive Alcohol-HIV/AIDS Research Center

LSUHSC-NO 酒精-艾滋病毒/艾滋病综合研究中心

• 批准号: 10534669
• 负责人: PATRICIA E. MOLINA
• 金额: $ 144.57万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534669
• 关键词: Acceleration; Address; Affect; Age; Aging; Alcohol consumption; Alcohols; Automobile Driving; Behavior; Behavioral; Behavioral Research; Biological Process; Biomedical Research; Caring; Cell Aging; Cell Death Induction; Center for Translational Science Activities; Chronic; Clinical; Clinical Research; Communities; Complement; Control Groups; Data; Data Analyses; Development; Diet; Disadvantaged; Disease; Enrollment; Ensure; Environment; Environmental Risk Factor; Equilibrium; Evolution; Exposure to; Funding; Gut Mucosa; HIV; HIV/AIDS; Health; Health Sciences; Healthcare; Immune; Immunologics; Individual; Inflammation; Inflammatory; Information Dissemination; Infrastructure; Institution; Intestinal Mucosa; Investigation; Knowledge; Longitudinal Studies; Longitudinal cohort; Louisiana; Mentors; Metabolic; Minority Groups; Modeling; Mucous Membrane; Neighborhoods; Neurologic Deficit; Oxidative Stress; Pathway interactions; Persons; Physical activity; Pilot Projects; Play; Population; Primates; Productivity; Public Health Schools; Publishing; Research; Research Personnel; Resources; Risk; Role; SIV; Scientist; Severities; Site; Stress; Training; Translational Research; Translations; Tropical Medicine; Underserved Population; Universities; Viral; alcohol consequences; alcohol effect; alcohol exposure; alcohol risk; alcohol use disorder; antiretroviral therapy; career development; clinically relevant; cohort; comorbidity; data management; demographics; experience; immune activation; multidisciplinary; nonhuman primate; novel; organizational structure; preclinical study; programs; research facility; senescence; sex; social factors; stressor; substance use; synergism; tissue injury; translational study; underserved minority; urban area; Acceleration; Address; Affect; Age; Aging; Alcohol consumption; Alcohols; Automobile Driving; Behavior; Behavioral; Behavioral Research; Biological Process; Biomedical Research; Caring; Cell Aging; Cell Death Induction; Center for Translational Science Activities; Chronic; Clinical; Clinical Research; Communities; Complement; Control Groups; Data; Data Analyses; Development; Diet; Disadvantaged; Disease; Enrollment; Ensure; Environment; Environmental Risk Factor; Equilibrium; Evolution; Exposure to; Funding; Gut Mucosa; HIV; HIV/AIDS; Health; Health Sciences; Healthcare; Immune; Immunologics; Individual; Inflammation; Inflammatory; Information Dissemination; Infrastructure; Institution; Intestinal Mucosa; Investigation; Knowledge; Longitudinal Studies; Longitudinal cohort; Louisiana; Mentors; Metabolic; Minority Groups; Modeling; Mucous Membrane; Neighborhoods; Neurologic Deficit; Oxidative Stress; Pathway interactions; Persons; Physical activity; Pilot Projects; Play; Population; Primates; Productivity; Public Health Schools; Publishing; Research; Research Personnel; Resources; Risk; Role; SIV; Scientist; Severities; Site; Stress; Training; Translational Research; Translations; Tropical Medicine; Underserved Population; Universities; Viral; alcohol consequences; alcohol effect; alcohol exposure; alcohol risk; alcohol use disorder; antiretroviral therapy; career development; clinically relevant; cohort; comorbidity; data management; demographics; experience; immune activation; multidisciplinary; nonhuman primate; novel; organizational structure; preclinical study; programs; research facility; senescence; sex; social factors; stressor; substance use; synergism; tissue injury; translational study; underserved minority; urban area

Abstract LSUHSC CARC Overall The Louisiana State University Health Sciences Center New Orleans (LSUHSC-NO) Comprehensive Alcohol- HIV/AIDS Research Center (CARC) is a multi-institutional, multidisciplinary team of scientists from LSUHSC and the Tulane National Primate Research Center (TNPRC) and School of Public Health and Tropical Medicine (TSPHTM) with a research focus on the interaction of alcohol use disorder (AUD), human immunodeficiency virus (HIV), and antiretroviral therapy (ART). The translational focus is the impact of at-risk alcohol consumption on risk for comorbidities in a longitudinal cohort of in-care virally-suppressed persons living with HIV (PLWH). We have demonstrated the relevance of the simian immunodeficiency virus (SIV) nonhuman primate (NHP) model to the clinical setting, revealed the deleterious impact of alcohol despite viremic control in in-care PLWH, and identified environmental (neighborhood) and behavioral (diet) factors that affect disease course and severity. The proposed studies evolve, expand, and refine our research strategy to a mechanistic bidirectional (NHP‒ PLWH‒NHP) translational investigation of the impact of AUD, HIV, and ART on comorbid conditions in an underserved cohort of PLWH. The scientific premise of the proposed studies is the observation that intestinal mucosa is an early site of alcohol-induced immunopathogenic changes in the alcohol-consuming, HIV/SIV- infected host that culminates in loss of mucosal barrier function and gut leak that promotes chronic immune activation, inflammation, and senescence, which we hypothesize increases risk for comorbidities in PLWH. An Administrative Core provides oversight, supports data management and analysis, and funds pilot projects to promote novel research investigations. Four Research Components (RCs) study in-care underserved PLWH and a sex- and age-matched HIV- control group, complemented by mechanistic studies in SIV+ and SIV- NHPs. RC1 investigates the impact of community and interpersonal stress on behavioral and chronic comorbidities among PLWH and the unique role that alcohol consumption plays in the pathways. RC2 and RC3 elucidate pathophysiological mechanisms of two comorbidities: metabolic dysregulation and neurological deficits. RC4 investigates the immunological mechanisms driving the balance between immune activation and activation- induced cell death that contribute to cell senescence and tissue injury with alcohol exposure. An Experimental and Analytical Resource Core provides support for all proposed studies. An Information Dissemination Core promotes training and accelerates the translation and dissemination of research findings to the scientific, health care, and lay communities. The CARC will continue to leverage and synergize with existing institutional resources. Access to a unique HIV+ population in a southeast urban region, the established expertise of CARC investigators in biomedical and behavioral research, state-of-the-art research facilities, outstanding scientific environment, and strong institutional support will ensure that the proposed CARC projects will continue to advance our understanding of the comorbid consequences of AUD, HIV/SIV, and ART in PLWH.

摘要LSUHSC CARC总体 路易斯安那州立大学健康科学中心新奥尔良（LSUHSC-NO）综合酒精 - 艾滋病毒/艾滋病研究中心（CARC）是来自LSUHSC和 杜兰国家灵长类动物研究中心（TNPRC）和公共卫生与热带医学学院 （TSPHTM）研究重点是酒精使用障碍的相互作用（AUD），人类免疫缺陷 病毒（HIV）和抗逆转录病毒疗法（ART）。翻译重点是高危酒精消费的影响 在纵向培养的人群中，有合并症的风险实际上抑制了艾滋病毒（PLWH）。 我们已经证明了猿猴免疫缺陷病毒（SIV）非人类灵长类动物（NHP）的相关性 临床环境的模型显示，酒精目的地病毒控制在护理中的损坏的影响， 并确定影响疾病病程和严重程度的环境（邻居）和行为（饮食）因素。 提出的研究将我们的研究策略进化，扩展和完善了机械双向的研究策略（NHP - PLWH = NHP）对AUD，HIV和ART对合并症的影响的翻译研究 服务不足的PLWH队列。拟议研究的科学前提是肠道的观察 粘膜是酒精诱导的酒精耗竭，HIV/SIV-的免疫致病变化的早期部位 感染的宿主最终导致粘膜屏障功能的丧失和肠道泄漏，从而促进慢性免疫 我们假设激活，感染和感应会增加PLWH合并症的风险。一个 行政核心提供监督，支持数据管理和分析，并为试点项目提供资金 促进新颖的研究调查。四个研究组件（RCS）研究中心欠缺的PLWH 以及由SIV+和SIV-NHP中的机械研究完成的性别和年龄匹配的HIV对照组。 RC1调查了社区和人际压力对行为和慢性合并症的影响 在PLWH和酒精消耗在途径中的独特作用。 RC2和RC3阐明 两种合并症的病理生理机制：代谢失调和神经系统缺陷。 RC4 研究了一种免疫机制，推动了免疫激活与激活之间的平衡 诱导的细胞死亡会导致细胞感应和随着酒精暴露的组织损伤。实验 分析资源核心为所有提出的研究提供了支持。信息传播核心 促进培训并加速研究结果的翻译和传播给科学，健康 关心和外行社区。 CARC将继续利用并协同现有机构 资源。在东南城市地区获得独特的艾滋病毒+人口，这是CARC的既定专业知识 生物医学和行为研究的研究人员，最先进的研究设施，出色的科学 环境和强大的机构支持将确保拟议的CARC项目将继续 促进我们对PLWH中AUD，HIV/SIV和艺术的合并后果的理解。