CELLULAR AND MOLECULAR GEROSCIENCE CoBRE

细胞和分子老年科学 CoBRE

• 批准号: 10536644
• 负责人: William Edmund Sonntag
• 金额: $ 210.69万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10536644
• 关键词: Address; Advisory Committees; Age; Aging; Animal Model; Appointment; Award; Basic Science; Behavior assessment; Biomedical Research; Cells; Cities; Clinical Research; Clinical Trials; Collaborations; Dedications; Degenerative polyarthritis; Disease; Ensure; Environment; Etiology; Event; Faculty; Failure; Fostering; Foundations; Functional disorder; Funding; Generations; Geroscience; Goals; Grant; Growth; Health Sciences; Heart Diseases; Hormonal; Impaired cognition; Infrastructure; Institution; Interdisciplinary Study; International; Intervention; Investments; Knowledge; Leadership; Literature; Longevity; Malignant Neoplasms; Medical Research; Medical center; Mentors; Molecular; Molecular Analysis; Oklahoma; Organism; Outcome; Participant; Phase; Phenotype; Prevalence; Process; Productivity; Program Development; Research; Research Personnel; Research Project Grants; Research Support; Scientist; Services; Stroke; Structure; Training; Translational Research; United States National Institutes of Health; Universities; Work; age related; career development; cellular imaging; disorder risk; expectation; experience; healthspan; human disease; improved; innovation; inter-institutional; multidisciplinary; next generation; novel; permissiveness; postmitotic; pre-clinical research; prevent; programs; recruit; statistics; success

There have been impressive advances in understanding the molecular and cellular mechanisms of aging, including the discovery of manipulations that delay aging and increase healthspan. Importantly, these interventions also reduce or prevent age-related diseases. These outcomes raise the possibility that multiple human diseases arise from a common cause – aging. The premise of this CoBRE Phase 1 is that the mechanisms of aging and the mechanisms of age-related diseases share common cellular and molecular processes that underlie healthspan and lifespan. An important corollary to this concept is that pre-clinical and clinical research on age-related diseases must incorporate an understanding of the cellular/molecular changes that occur with age in order to adequately develop treatments for age-related diseases. Here, we propose a multidisciplinary, inter-departmental, and inter-institutional CoBRE program focused on Cellular and Molecular Geroscience. Geroscience is a new, interdisciplinary scientific field that addresses the cellular and molecular events that dramatically increase the risk for disease with age, create a ‘permissive milieu’ and, as a result, disease increases exponentially. Our program has exceptional institutional support. The program is highly innovative in that it combines mentoring of promising junior investigators (PJIs) by outstanding scientific experts who are currently studying mechanisms of aging and by faculty investigating age-related disease in a manner that will increase both the quantity and quality of on-going disease-related research in the context of the aging organism. These goals will be accomplished through the mentoring of PJIs, who have faculty appointments at OUHSC; recruiting senior investigators to the OUHSC campus; and developing the necessary infrastructure for support of the research program. The specific aims for the program are: 1. Develop and expand institutional biomedical research in Geroscience through the mentoring of PJIs by highly experienced, dedicated senior investigators. 2. Enhance the infrastructure critical for expanding Geroscience research in Oklahoma. 3. Foster collegial and collaborative relationships between CoBRE investigators and other scientists. 4. Establish milestones and expectations that ensure the success of the program and its participants. The outcome will be a sustainable, interdisciplinary research structure on the OUHSC campus, which will produce a new generation of collaborative Geroscience-trained researchers and establish OUHSC as a leader in Geroscience.

在理解衰老的分子和细胞机制方面取得了令人瞩目的进展， 包括发现延缓衰老和延长健康寿命的方法。 干预措施还可以减少或预防与年龄相关的疾病。 人类疾病源于一个共同原因——衰老。CoBRE 第一阶段的前提是， 衰老机制和与年龄相关的疾病机制具有共同的细胞和分子机制 这个概念的一个重要推论是临床前和寿命的过程。 与年龄相关疾病的临床研究必须纳入对细胞/分子变化的理解 为了充分开发与年龄相关的疾病的治疗方法，我们提出了一种随着年龄增长而发生的疾病。 多学科、跨部门和跨机构的 CoBRE 项目，重点关注细胞和分子 老年科学是一个新的跨学科科学领域，研究细胞和分子。 随着年龄的增长，疾病风险急剧增加的事件创造了一种“宽容的环境”，因此， 我们的计划得到了高度的机构支持。 创新之处在于它结合了杰出科学专家对有前途的初级研究人员（PJI）的指导 目前正在研究衰老机制的人以及教师以某种方式调查与年龄相关的疾病 这将提高老龄化背景下正在进行的疾病相关研究的数量和质量 这些目标将通过 PJI 的指导来实现，PJI 的教职人员为： OUHSC 招募高级研究人员并为 OUHSC 开发必要的基础设施； 该研究计划的具体目标是： 1. 发展和扩大机构。 通过经验丰富、敬业的高级人员对 PJI 的指导，进行老年科学的生物医学研究 2. 加强对扩大俄克拉荷马州老年科学研究至关重要的基础设施。 4. 建立 CoBRE 研究者和其他科学家之间的合作关系。 确保计划及其参与者取得成功的里程碑和期望。 OUHSC 校园内可持续的跨学科研究结构，将培养新一代 合作老年科学培训的研究人员，并将 OUHSC 打造为老年科学领域的领导者。