Spontaneous Speech and Health Disparities in Risk of Cognitive Decline: WHICAP Offspring Ancillary Study

自发言语和认知衰退风险的健康差异：WHICAP 后代辅助研究

• 批准号: 10538578
• 负责人: ADAM M BRICKMAN
• 金额: $ 65.66万
• 依托单位: KENT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10538578
• 关键词: African American; African American population; Aging; Alleles; Alzheimer' s Disease; Alzheimer' s disease risk; Amyloid; Amyloid deposition; Ancillary Study; Biological; Biological Factors; Biological Markers; Brain; Cardiovascular Diseases; Cellular Phone; Cognitive; Complex Analysis; Data; Data Collection; Early Diagnosis; Education; Elderly; Enrollment; Ethnic Origin; Ethnic Population; Exhibits; Future; Genetic; Height; Hippocampus; Hispanic; Hispanic Populations; Impaired cognition; Incidence; Income; Individual; Language; Late Onset Alzheimer Disease; Magnetic Resonance Imaging; Measures; Mediator; Medical; Methods; Minority; Minority Groups; Monitor; Names; Nerve Degeneration; Neuronal Plasticity; Neuropsychological Tests; Neuropsychology; Not Hispanic or Latino; Parents; Participant; Population; Population Heterogeneity; Positron-Emission Tomography; Race; Research; Risk; Risk Factors; Sampling; Semantics; Speech; Thinness; Time; Variant; Washington; Work; bilingualism; burden of illness; cognitive function; cognitive reserve; cohort; community setting; ethnic disparity; ethnic diversity; executive function; genetic testing; health disparity; indexing; insight; instrument; lexical; neural; new technology; novel marker; offspring; perceived discrimination; pre-clinical; protective effect; racial disparity; racial diversity; racial population; screening; social culture; sociocultural determinant; structural imaging; tau Proteins; white matter

Project Summary/Abstract The proposed ancillary study looks to better understand racial/ethnic disparities in Alzheimer's disease (AD) by investigating spontaneous speech as part of the Washington Heights/Inwood Columbia Aging Project (WHICAP) Offspring Study. Limitations of existing cognitive screening instruments is a known contributor to racial/ethnic disparities in AD and recent work suggests that speech analysis may be a sensitive marker of cognitive decline and future AD. New technological advances raise the possibility that automated speech analysis could be conducted using smartphones in community settings, creating an inexpensive and scalable approach to early detection. However, many challenges remain in developing this method, including a very limited understanding of the biological underpinnings of spontaneous speech in at-risk individuals (e.g., hippocampal volume, amyloid deposition, contribution of executive function vs. language). We propose to examine spontaneous speech as part of the ongoing WHICAP Offspring Study (RF1AG054070, RF1AG058067). This large project is enrolling a diverse cohort (>70% minorities) of pre-clinical participants with varying degrees of risk for AD using medical, genetic, and neuropsychological testing (N = 3000), structural MRI (N = 1000), and amyloid and tau PET imaging (N = 150 for each). Both English and Spanish speakers are included. One measure of spontaneous speech has been included since study onset and a second brief measure would be added. We hypothesize that spontaneous speech will reflect a combination of both biological and sociocultural risk factors to AD and that bilingualism will show protective effects. By leveraging the rich data collection of the WHICAP Offspring Study, this application would generate substantial new insight into the basic underpinnings of spontaneous speech in diverse pre-clinical samples, as well as determine the feasibility of using speech analysis as a novel biomarker of AD risk. Additionally, should the cohort be followed longitudinally, the ability of spontaneous speech to predict future incidence of AD in racially/ethnically diverse samples over time could also be evaluated.

项目摘要/摘要 拟议的辅助研究旨在更好地了解阿尔茨海默氏病（AD）的种族/种族差异 作为华盛顿高地/Inwood哥伦比亚老化项目的一部分，调查自发演讲 （WHICAP）后代研究。现有认知筛选工具的局限性是已知的贡献者 AD和最近工作中的种族/种族差异表明，语音分析可能是敏感的标志 认知能力下降和未来的广告。新技术进步增加了自动演讲的可能性 可以在社区环境中使用智能手机进行分析，从而创造便宜且可扩展的 早期检测方法。但是，在开发这种方法中仍然存在许多挑战，包括一个非常 对处于危险的个体中自发性语音的生物学基础的了解有限（例如 海马体积，淀粉样蛋白沉积，执行功能与语言的贡献）。 我们建议作为正在进行的Whicap后代研究的一部分（RF1AG054070， RF1AG058067）。这个大型项目正在招募各种队列（> 70％的少数族裔）的临床前参与者 使用医学，遗传和神经心理学测试（n = 3000）的AD风险不同程度 结构MRI（n = 1000），淀粉样蛋白和tau PET成像（每种n = 150）。英语和西班牙 包括扬声器。自研究发作和一个 将添加第二个简短措施。我们假设自发演讲将反映出 生物学和社会文化危险因素均为AD，双语主义将表现出保护作用。 通过利用WHICAP后代研究的丰富数据收集，该应用将产生 对各种临床前样本中自发演讲的基本基础的大量新见解， 并确定将语音分析用作AD风险的新生物标志物的可行性。另外，应该 纵向遵循队列，自发语音预测AD未来发生率的能力 随着时间的流逝，种族/种族上不同的样本也可以评估。

项目成果

Examining sex differences in the association between sedentary behavior and cognitive function in bariatric surgery patients.

检查减肥手术患者久坐行为与认知功能之间关系的性别差异。

• DOI: 10.1016/j.soard.2023.06.004
• 发表时间: 2023
• 期刊: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
• 作者: Bhatia,Urja;Bond,Dale;Gunstad,John;Carroll,Ian;Crosby,Ross;Mitchell,JamesE;Peat,ChristineM;Steffen,Kristine;Heinberg,Leslie
• 通讯作者: Heinberg,Leslie

Lexical Speech Features of Spontaneous Speech in Older Persons With and Without Cognitive Impairment: Reliability Analysis.

• DOI: 10.2196/46483
• 发表时间: 2023-10-10
• 期刊: JMIR aging
• 影响因子: 4.9

Automated assessment of speech production and prediction of MCI in older adults.

• DOI: 10.1080/23279095.2020.1864733
• 发表时间: 2022-09
• 期刊: Applied neuropsychology. Adult
• 作者: Sanborn V;Ostrand R;Ciesla J;Gunstad J
• 通讯作者: Gunstad J