HPV and HIV Co-Infection: Clinical, Socio-Behavioral, and Microbiome Implications

HPV 和 HIV 合并感染：临床、社会行为和微生物组影响

• 批准号: 10529816
• 负责人: JENNIFER L FRUSTINO
• 金额: $ 43.33万
• 依托单位: ERIE COUNTY MEDICAL CENTER CORP.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-02 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10529816
• 关键词: Address; Adherence; Anus; Behavioral; Biological; Biology; CD4 Lymphocyte Count; Clinical; Dental Hygiene; Development; Disease; Disease Progression; Epidemiology; Foundations; Functional disorder; Funding Opportunities; Genotype; Goals; HIV; HIV-1; Human Papilloma Virus Vaccination; Human Papillomavirus; Human papilloma virus infection; Immune System Diseases; Immunologics; Individual; Infection; Intraepithelial Neoplasia; Knowledge; Lesion; Link; Longitudinal prospective study; Malignant Neoplasms; Measures; Mission; Molecular; Monitor; Mucous Membrane; National Institute of Dental and Craniofacial Research; Oral; Oral Manifestations; Oral health; Oropharyngeal Squamous Cell Carcinoma; Outcome; Pathway interactions; Patients; Persons; Prevention approach; Prospective cohort study; Regimen; Research; Research Design; Risk; Skin Papilloma; Social Behavior; Swab; Testing; Tobacco; Tooth structure; Translating; Viral Load result; Virus; alcohol exposure; antiretroviral therapy; base; cancer invasiveness; co-infection; cohort; dysbiosis; experience; health inequalities; immunological status; infection rate; innovation; insight; microbiome; oral HPV; oral HPV infection; oral microbiome; oral wart; prevent; rectal microbiome

Project Summary Abstract There is a critical need to better understand the epidemiology and biology of oral human papillomavirus (HPV) infection in people living with HIV (PLWH). This will, in turn, help identify the pathophysiology leading to HPV- related manifestations such as oral and anal warts as well as oropharyngeal squamous cell carcinoma. This is an exploratory cross-sectional prospective cohort study designed to help address this need. The goal of this study, in line with the mission of the National Institute of Dental and Craniofacial Research (NIDCR), is to identify markers that will help predict, prevent, and ultimately treat HPV infection and its sequelae in PLWH based on underlying biologic, clinical, and socio-behavioral factors. Oral and anal swabs will be obtained from HPV+ and HPV- PLWH to evaluate the microbiome in the two groups. Immune status (CD4 count and viral load) and antiretroviral therapy (ART) regimen will be compared in the two groups and in relation to the microbiome. Clinical findings (oral and anal lesions, diseased, missing, filled teeth) and socio-behavioral factors (sexual practices, tobacco/alcohol exposure) will also be compared in HPV+ and HPV- PLWH. The central hypothesis is that oral HPV co-infection with HIV will correlate with a certain degree of oral and anal microbiome dysbiosis, dysregulated immune status and specific socio-behavioral factors. Specific Aim 1: Elucidate enrichment pathways to further understand oral and anal microbiome dysbiosis in PLWH. Specific Aim 2: Examine immune status as well as ART regimen in PLWH with respect to HPV infection. Specific Aim 3: Characterize the clinical and socio- behavioral aspects that increase risk of HPV infection in PLWH. The proposed study should identify correlates of variables that offer insight into HIV/HPV co-infection. Future research plans will include a prospective longitudinal study to monitor for HPV persistence and the development of cancer in this cohort of PLWH.

项目概要 摘要 迫切需要更好地了解口腔人乳头瘤病毒 (HPV) 的流行病学和生物学 HIV 感染者 (PLWH) 的感染。反过来，这将有助于确定导致 HPV 的病理生理学 相关表现，如口腔和肛门疣以及口咽鳞状细胞癌。这是 旨在帮助满足这一需求的探索性横断面前瞻性队列研究。此举的目标 这项研究符合国家牙科和颅面研究所 (NIDCR) 的使命，旨在确定 有助于预测、预防和最终治疗 PLWH 中 HPV 感染及其后遗症的标记物 潜在的生物学、临床和社会行为因素。口腔和肛门拭子将从 HPV+ 和 HPV-PLWH 用于评估两组的微生物组。免疫状态（CD4 计数和病毒载量）和 将比较两组的抗逆转录病毒治疗（ART）方案以及与微生物组的关系。临床 结果（口腔和肛门病变、患病、缺失、补牙）和社会行为因素（性行为、 烟草/酒精暴露）也将在 HPV+ 和 HPV- PLWH 中进行比较。中心假设是口语 HPV 与 HIV 合并感染将与一定程度的口腔和肛门微生物群失调、失调相关 免疫状态和特定的社会行为因素。具体目标 1：阐明进一步富集途径 了解 PLWH 的口腔和肛门微生物群失调。具体目标 2：检查免疫状态以及 PLWH 中针对 HPV 感染的 ART 方案。具体目标 3：描述临床和社会特征 行为方面会增加 PLWH 感染 HPV 的风险。拟议的研究应确定相关性 提供深入了解 HIV/HPV 合并感染的变量。未来的研究计划将包括前瞻性 监测这组 PLWH 中 HPV 持续性和癌症发展的纵向研究。