Cognitive Science to Radiology: Using EEG and Eye-tracking to Determine Why, How, and When Novices and Radiologists Miss Signs of Breast Cancer in Multiple-abnormality Mammography and Tomosynthesis

从认知科学到放射学：使用脑电图和眼动追踪来确定新手和放射科医生在多异常乳房 X 线摄影和断层合成中错过乳腺癌迹象的原因、方式和时间

• 批准号: 10525777
• 负责人: Stephen Adamo
• 金额: $ 12.53万
• 依托单位: UNIVERSITY OF CENTRAL FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10525777
• 关键词: 3-Dimensional; Address; Affect; Attention; Breast Cancer Detection; Cancer Detection; Cognitive; Cognitive Science; Data; Detection; Digital Breast Tomosynthesis; Digital Mammography; Educational workshop; Electroencephalogram; Goals; Grant; Image; Imaging technology; Institution; Knowledge; Life; Malignant Neoplasms; Mammography; Medical Imaging; Memory; Mentors; Methodology; Methods; Mission; Modality; Multiple Abnormalities; Normalcy; Outcome; Public Health; Radiology Specialty; Research; Research Personnel; Research Technics; Screening for cancer; Screening procedure; Short-Term Memory; Techniques; Testing; Three-Dimensional Image; Three-Dimensional Imaging; Time; Training; United States; United States National Institutes of Health; Visual; Woman; Work; attentional bias; base; breast imaging; cancer diagnosis; cancer imaging; improved; innovation; malignant breast neoplasm; meetings; mental representation; neuromechanism; novel; oculomotor; radiological imaging; radiologist; relating to nervous system; satisfaction; tomosynthesis; virtual; visual tracking

Satisfaction of Search (SOS), where an abnormality is missed after a previous abnormality was found, is a pervasive problem across different types of images, yet their impact on breast cancer detection is un- known. Radiology and cognitive science have independently investigated why, how, and when SOS oc- curs. The objectives of this grant are to bridge cognitive science research techniques with radiology to de- termine: 1) the neural underpinnings of SOS, 2) the extent to which SOS affects breast cancer detection, 3) the extent to which advancements in imaging technology alleviates SOS, and 4) how expertise affects SOS error rates. My central hypothesis is SOS contributes to breast cancer misses because a found ab- normality becomes an attentional template. An attentional template is known in cognitive science as an enhanced representation of a target maintained within memory and biases attention in search. The ra- tionale for this project is when a first target is detected, it becomes an attentional template that utilizes and biases attention necessary for detecting subsequent targets making searchers prone to SOS. However, SOS may be mitigated: 1) by changing search strategies to counteract a first target becoming an atten- tional template, 2) with advances in imaging technology, and 3) with expertise in breast cancer detection. These influences need to be investigated to determine the extent to which they can alleviate SOS. This work will pursue four specific aims to test the central hypothesis: 1) identify a mechanistic account for SOS, 2) determine the extent to which SOS accounts for breast cancer misses, 3) compare SOS between mammography and tomosynthesis, and 4) compare SOS error rates between different levels of expertise. The research proposed is innovative because it will: 1) identify a mechanism responsible for SOS; 2) use EEG and eye-tracking to study the neural basis of SOS; 3) use realistic, virtual breast images to investi- gate the extent to which SOS affects breast cancer detection; 4) determine the extent to which the SOS results from simplified search displays replicate in realistic-looking medical images; 5) be the first time SOS is investigated with 3D imaging; and 6) determine the extent to which SOS rates vary by expertise in breast cancer detection. The proposed research is significant because: 1) it will develop a neural under- standing of how SOS contributes to cancer detection; 2) determine how SOS varies across different search modalities and by expertise; and 3) ultimately improve breast cancer detection by determining how these influences impact SOS rates. To complete the proposed research, in pursuit of his long-term goal of becoming an independent researcher at a Tier-I institution, the PI will train using EEG and eye-tracking. His training will include auditing graduate courses, attending workshops, weekly meetings/training with his mentors, and bi-annual assessments of his EEG/eye-tracking expertise with his mentors.

搜索（SOS）的满意度（SOS）在发现先前异常后错过异常，这是一个 不同类型图像的普遍问题，但它们对乳腺癌检测的影响却没有 已知。放射学和认知科学已经独立研究了原因，如何以及何时sos oc- 诅咒。这笔赠款的目标是桥接认知科学研究技术，以放射学以进行放射学 术语：1）SOS的神经基础，2）SOS影响乳腺癌检测的程度， 3）成像技术中进步的程度减轻了SOS和4）专业知识如何影响 SOS错误率。我的中心假设是SOS导致了乳腺癌的失误，因为发现了 正态性成为一个注意模板。注意模板在认知科学中被称为 增强了维持在内存中的目标的表示，并在搜索中偏向关注。 ra- 该项目的Tionale是在检测到第一个目标的时候，它成为了使用和使用的注意模板 检测随后的目标所必需的偏见，使搜索者容易进入SOS。然而， SOS可能会得到缓解：1）通过改变搜索策略来抵消第一个目标，成为一个目标 Tional模板，2）具有成像技术的进步，以及3）具有乳腺癌检测方面的专业知识。 需要研究这些影响，以确定它们可以减轻SOS的程度。这 工作将追求四个特定的目标来检验中心假设：1）确定机械账户 SOS，2）确定SOS在多大程度上解释了乳腺癌的错过，3）比较SOS 乳房X线摄影和间歇合成，以及4）比较不同水平的专业知识之间的SOS错误率。 提出的研究具有创新性，因为它将：1）确定一种负责SOS的机制； 2）使用 脑电图和眼睛跟踪，以研究SOS的神经基础； 3）使用现实的虚拟乳房图像进行投资 - 门口SOS影响乳腺癌检测的程度； 4）确定SOS的程度 简化搜索的结果显示在现实的医学图像中复制； 5）是第一次 SOS通过3D成像进行了研究； 6）确定SOS的比率因专业知识而异 乳腺癌检测。拟议的研究很重要，因为：1）它将发展出神经不足 SOS如何促进癌症检测的地位； 2）确定SOS如何在不同的不同 搜索方式和专业知识； 3）最终通过确定如何改善乳腺癌检测 这些影响影响SOS率。完成拟议的研究，以追求他的长期目标 PI成为一级I机构的独立研究人员，将使用脑电图和眼球训练进行训练。 他的培训将包括审计研究生课程，参加研讨会，每周会议/与他的培训 导师和他的指导者对他的脑电图/眼睛追踪专业知识的每两年评估。