Research Training in Natural Product Complementary and Integrative Health

天然产品补充和综合健康研究培训

• 批准号: 10521255
• 负责人: TAIFO MAHMUD
• 金额: $ 26.53万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10521255
• 关键词: Complementary Health; Integrative Medicine; Natural Products; Research Training

PROJECT SUMMARY/ABSTRACT Founded 120 years ago, the Oregon State University (OSU) College of Pharmacy is one of the oldest in the United States and has been a leader in natural products research since our predoctoral training program in Pharmaceutical Sciences began in 1952. Founded in 1973 by two-time Nobel Laureate Linus Pauling and housed in the state-of-the-art Linus Pauling Science Center on the OSU campus, the Linus Pauling Institute (LPI) remains focused on using micronutrients, phytochemicals and dietary supplements to prevent disease and maintain human health. Our graduates occupy leadership positions in academia, industry and government in the United States and throughout the world. Historically, natural products have accounted for over half of all therapeutic agents, and today are still the inspiration of nearly 40% of new drugs. Training young scientists for careers in natural products and dietary supplements research is a core mission of our College of Pharmacy and the LPI and will be the focus of this training grant. To address the need to train a new generation of experts in research concerning natural products drug discovery and in the safety and efficacy of dietary supplements, we propose to establish a new training grant program that will enroll 5 predoctoral trainees at a time. Currently, there is no training grant based in the OSU College of Pharmacy or the LPI. Our mentor team includes faculty with expertise in marine, microbial and botanical natural products and dietary supplements as well as natural product genomics, cancer therapy, chemoprevention, pharmacology, dietary supplements, organic synthesis, and biosynthesis. Our leadership team includes co-Program Leaders with experience leading a T32 training program (Dr. van Breemen) and experience serving as a director of graduate studies for our department (Dr. Mahmud). Finally, our training program will be enhanced by exceptional institutional commitment in the forms of administrative support from the OSU College of Pharmacy, the Department of Pharmaceutical Sciences and the LPI and financial support from the OSU Graduate School as partial tuition waivers.

项目概要/摘要 俄勒冈州立大学 (OSU) 药学院成立于 120 年前，是美国最古老的药学院之一 自从我们在美国的博士前培训项目以来，一直是天然产物研究的领导者 制药科学始于 1952 年。由两届诺贝尔奖获得者莱纳斯·鲍林 (Linus Pauling) 和 1973 年创立 莱纳斯鲍林研究所 (Linus Pauling Institute) 位于俄勒冈州立大学校园最先进的莱纳斯鲍林科学中心 (LPI) 仍然专注于使用微量营养素、植物化学物质和膳食补充剂来预防疾病 并维护人类健康。我们的毕业生在学术界、工业界和政府中担任领导职务 在美国和世界各地。从历史上看，天然产品占到了一半以上 治疗剂，至今仍然是近 40% 新药的灵感来源。培训年轻科学家 天然产品和膳食补充剂研究的职业生涯是我们药学院的核心使命 和 LPI，将成为本次培训补助金的重点。为满足培养新一代人才的需要 天然产物药物发现以及饮食安全性和功效研究方面的专家 作为补充，我们建议建立一个新的培训资助计划，将在一个大学招收 5 名博士前培训生。 时间。目前，俄勒冈州立大学药学院或 LPI 没有培训补助金。我们的导师团队 包括在海洋、微生物和植物天然产品和膳食补充剂方面具有专业知识的教师 以及天然产物基因组学、癌症治疗、化学预防、药理学、膳食补充剂、 有机合成、生物合成。我们的领导团队包括经验丰富的联合项目领导者 领导 T32 培训计划（van Breemen 博士）并担任研究生院主任的经验 我们部门（马哈茂德博士）。最后，我们的培训计划将通过卓越的机构得到加强 俄勒冈州立大学药学院、系的行政支持形式的承诺 药学科学和 LPI 以及 OSU 研究生院的部分学费资助 豁免。