Polygenic Risk Moderates the Impact of Greenness on Cardiovascular Health among HCHS/SOL Hispanic/Latinos

多基因风险调节绿色对 HCHS/SOL 西班牙裔/拉丁裔心血管健康的影响

• 批准号: 10517620
• 负责人: Scott Charles Brown
• 金额: $ 5.7万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10517620
• 关键词: Blood Glucose; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Cholesterol; Code; Environment; Event; Exposure to; Genetic; Genetic Predisposition to Disease; Genetic Risk; Grant; Health Benefit; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hypertension; Individual; Intervention; Latino Population; Life Style; Lipids; Logistic Regressions; Measures; Metabolic syndrome; Minority Groups; Modeling; Neighborhoods; Obesity; Outcome; Parents; Participant; Plants; Policies; Populations at Risk; Research; Risk; Risk Factors; Trees; Underserved Population; Work; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cohort; environmental intervention; genetic variant; high risk; improved; lifestyle factors; novel; polygenic risk score; protective factors; public health relevance; secondary analysis

Polygenic Risk Moderates the Impact of Greenness on Cardiovascular Health among HCHS/SOL Hispanic/Latinos ABSTRACT Hispanics/Latinos, the largest U.S. minority group, are at relatively high risk for metabolic syndrome (MetS) which is comprised of multiple cardiovascular disease (CVD) risk factors including obesity, high blood pressure, high cholesterol, and high blood glucose. Neighborhood greenness (vegetative presence) is a novel and understudied protective factor for CVD and MetS, with emerging evidence suggesting that reductions in CVD and MetS could be achieved by optimizing environmental greenness. However, a complete understanding of “how” and “for whom” greenness provides cardiovascular health benefits has not been fully elucidated, with recent work now showing that environment and lifestyle exposure can interact with genetic susceptibility to CVD. However, no study to date has examined whether genetics moderates the relationship of environmental greenness exposure to CVD or MetS. The supplement therefore proposes to examine: (1) whether genetics moderates the relationship of greenness to cardiovascular health; (2) whether those participants with the greatest genetic risk for CVD show the greatest benefit of high greenness exposures when compared to those participants with lower genetic risk for CVD; and (3) which specific genetic variants may be contributing most to the moderating effects of genetics on cardiovascular health. Building on the parent study (R01-HL-148880), this proposed supplemental study will be the first to investigative whether a polygenic risk score (PRS) indicating a higher risk of CVD, moderates the effect of greenness on cardiovascular health. We will do so by simultaneously investigating the effects of the PRS and Greenness, and their interaction, on cardiovascular health using conditional logistic regression models as has been previously used to model the interaction of genetic risk scores and lifestyle factors on cardiovascular health in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL) cohort. Therefore, the primary aim of the proposed supplement is to examine whether a polygenic risk score (PRS) indicating a higher risk of CVD, moderates the effect of greenness on cardiovascular health. We hypothesize that, when compared to participants in the lowest two tertiles of polygenic risk score (PRS) for cardiovascular outcomes, those participants in the highest tertile of PRS (i.e., showing the highest risk for CVD) will show a greater benefit of high greenness exposures on cardiovascular health, the latter measured via blood pressure, blood glucose, and lipid profile. Finally, a planned secondary analysis will seek to identify the specific genetic variants contributing to the moderating effects of PRS on the relationships of greenness to cardiovascular health. Identifying these genetic variants may help explain the mechanism underlying the greenness effect on cardiovascular health. Findings from this proposal will advance our understanding of how genetic risk for CVD may moderate the impact of greenness on cardiovascular health, which may be important for planning policy or environmental interventions (e.g., tree planting; parks) to best reduce the risk of CVD in Hispanics/Latinos.

多基因风险调节绿色对HCHS/SOL中心血管健康的影响 西班牙裔/拉丁裔 抽象的 西班牙裔/拉丁美洲人是美国最大的少数群体，其代谢综合征（Mets）的风险相对较高 由多种心血管疾病（CVD）危险因素组成，包括肥胖，高血压，高 胆固醇和高血糖。邻居绿色（植物存在）是一部小说，很明白 CVD和Mets的保护因素，并有新兴的证据表明CVD和Mets的减少可能 可以通过优化环境绿色来实现。但是，完全了解“如何”和“ 谁尚未完全阐明绿色，提供心血管健康益处，现在最近的工作 表明环境和生活方式暴露会与CVD的遗传敏感性相互作用。但是，不 迄今为止的研究已经检查了遗传学是否缓和了环境绿色暴露的关系 到CVD或Mets。因此，补充提案要检查：（1）遗传学是否适中 绿色与心血管健康的关系； （2）那些具有最大遗传风险的参与者是否 与CVD相比 CVD的遗传风险； （3）哪些特定的遗传变异可能对调节作用有最大的贡献 关于心血管健康的遗传学。 在父母研究（R01-HL-148880）的基础上，这项拟议的补充研究将是第一个进行调查的研究 多基因风险评分（PRS）是否表明CVD风险更高，都会缓解绿色对 心血管健康。我们将通过简单地调查PR和绿色的影响来做到这一点，然后 它们的相互作用，在心血管健康上使用条件逻辑回归模型， 用于建模西班牙裔心血管健康的遗传风险评分和生活方式因素的相互作用 社区健康研究 /拉丁美洲人研究（HCHS / SOL）队列。因此，提议的主要目的 补充是检查多基因风险评分（PRS）是否表明CVD风险更高 绿色对心血管健康的影响。我们假设，与最低的参与者相比 对于心血管结局的两个多基因风险评分（PRS）的两块，这些参与者处于最高的三位数 PRS（即表现出最高的CVD风险）将显示出高绿色暴露的更大好处 心血管健康，后来通过血压，血糖和脂质谱测量。最后，计划了 次要分析将旨在确定有助于PR的调节作用的特定遗传变异 关于绿色与心血管健康的关系。识别这些遗传变异可能有助于解释 绿色对心血管健康的影响的机制。该提议的发现将 促进我们对CVD的遗传风险如何缓和绿色对的理解 心血管健康，这对于计划政策或环境干预措施可能很重要（例如，树木 种植；公园）最好降低西班牙裔/拉丁裔CVD的风险。