Disrupted Sleep in Somali Americans – Implications for Hypertension Risk

索马里裔美国人的睡眠中断 — 对高血压风险的影响

• 批准号: 10518658
• 负责人: Virend K Somers
• 金额: $ 78.72万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-10 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10518658
• 关键词: Address; Advisory Committees; Africa; African ancestry; Age; American; Amphetamines; Behavior; Behavioral; Biological; Biological Factors; Black Populations; Blood Pressure; Cardiovascular Diseases; Central obesity; Clinic; Collaborations; Communities; Consumption; Data; Diabetes Mellitus; Diagnosis; Disease; Dislocations; Drowsiness; Environmental Risk Factor; Epidemic; Future; Genotype; Geography; Health; Health Disparities Research; Health Priorities; High Prevalence; Hour; Hypertension; Immigrant; Immigrant community; Immigration; Individual; Intervention; Knowledge; Language; Measures; Mediating; Mediator of activation protein; Metabolic Diseases; Metabolic syndrome; Minnesota; Modeling; National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; Neighborhoods; Obstructive Sleep Apnea; Outcome; Pathway interactions; Patients; Physical activity; Play; Polysomnography; Population; Positioning Attribute; Prevention; Process; Public Health; Refugee Camp; Reporting; Research; Research Priority; Risk; Risk Factors; Role; Services; Severities; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Social Work; Sodium Chloride; Stimulant; Strategic vision; Stress; Sum; Time; Translating; Visceral fat; Wakefulness; base; blood pressure elevation; cardiovascular disorder risk; cardiovascular health; community based participatory research; comorbidity; contextual factors; experience; health disparity; high risk; hypertensive; innovation; insight; interdisciplinary approach; obesity risk; patient engagement; physical inactivity; poor sleep; prevent; protective factors; psychological distress; psychosocial; psychosocial stressors; racism; recruit; salt intake; screening; sex; sleep abnormalities; social culture; socioeconomic disadvantage; volunteer

Disrupted sleep, a major public health issue, independently increases risk for cardiovascular disease (CVD). Blacks have increased rates of sleep deficiency, which are likely under-reported. Importantly, these data relate primarily to those of West African ancestry. Our current knowledge of sleep disruption in Blacks, already severely limited in scope, cannot be readily applied to Somali Americans. The majority of Somali immigrants have settled in Minnesota, placing our Minnesota-based research team in a unique position to comprehensively study the mechanisms and consequences of disrupted sleep as a mediator of cardiovascular health disparities in this population. Our preliminary data suggest that Somali Americans have a high likelihood of disrupted sleep, which may put them at increased risk for hypertension and other CVD. Underlying sociocultural, behavioral, environmental and biological factors likely contribute to an increased risk for sleep deficiencies. We therefore propose an inter-disciplinary approach using a socioecological model informed by the National Institute on Minority Health and Health Disparities (NIMHD) Research Framework to determine the types and severity of undiagnosed sleep deficiencies in otherwise healthy Somali Americans, identify mechanisms contributing to their disrupted sleep, and examine the role of sleep deficiencies in raising blood pressure (BP). Our central hypothesis is that Somali Americans will have a high likelihood of sleep deficiencies attributable in part to unique multilevel individual, psychosocial, contextual and behavioral factors, which exert deleterious biological effects. We propose the following aims: Aim 1: Determine the types and severity of previously undiagnosed sleep deficiencies in otherwise healthy Somali Americans. Hypothesis 1: Somali Americans have a high (>50%) likelihood of previously undiagnosed sleep deficiencies (short sleep (<6 hours), insomnia and obstructive sleep apnea). Aim 2: Apply the NIMHD Research Framework to define psychosocial, behavioral, environmental and biological mechanisms mediating sleep deficiencies in Somali Americans. Hypothesis 2: Unique multilevel individual, cultural and environmental risk and protective factors play a mechanistic role in mediating an increased likelihood of disrupted sleep in Somali Americans. Aim 3: Examine the relationship between sleep deficiencies and increased BP in Somali Americans. Hypothesis 3: BP during wakefulness and/or sleep will be increased in those subjects with disrupted sleep, commensurate with type and severity of sleep deficiency, and moderated by factors such as sex and age. The expected outcome of this proposal will be a mechanistic pathway incorporating the NIMHD Research Framework to identify psychosocial, behavioral, contextual and biological factors mediating sleep deficiencies and related increases in BP, and consequently hypertension risk, thus addressing important knowledge gaps in understanding sleep-related health disparities and their consequences in Somali Americans.

睡眠中断是一个重大的公共卫生问题，它会独立增加心血管疾病的风险 （化学气相沉积）。黑人睡眠不足的比例有所增加，但这一情况可能没有得到充分报告。重要的是，这些 数据主要涉及西非血统。我们目前对黑人睡眠干扰的了解， 范围已经受到严重限制，不能轻易适用于索马里裔美国人。大多数索马里人 移民已在明尼苏达州定居，这使我们位于明尼苏达州的研究团队处于独特的地位 全面研究睡眠中断作为心血管疾病中介因素的机制和后果 该人群的健康差异。我们的初步数据表明索马里裔美国人很有可能 睡眠中断，这可能会增加他们患高血压和其他心血管疾病的风险。潜在的 社会文化、行为、环境和生物因素可能会导致睡眠风险增加 的不足。因此，我们提出使用社会生态模型的跨学科方法 由国家少数族裔健康和健康差异研究所 (NIMHD) 研究提供信息 确定健康人群中未确诊睡眠不足的类型和严重程度的框架 索马里裔美国人，确定导致睡眠中断的机制，并研究 睡眠不足会导致血压升高。我们的中心假设是索马里裔美国人会 睡眠不足的可能性很大，部分原因是独特的多层次个人、社会心理、 背景和行为因素，会产生有害的生物效应。我们提出以下目标： 目标 1：确定以前未诊断的睡眠不足的类型和严重程度 健康的索马里美国人。假设 1：索马里裔美国人以前有过类似经历的可能性很高（>50%） 未确诊的睡眠不足（睡眠不足（<6 小时）、失眠和阻塞性睡眠呼吸暂停）。 目标 2：应用 NIMHD 研究框架来定义心理社会、行为、环境和 调节索马里裔美国人睡眠不足的生物机制。假设2：独特 多层次的个人、文化和环境风险和保护因素在 调解索马里裔美国人睡眠中断的可能性增加。 目标 3：研究索马里裔美国人睡眠不足与血压升高之间的关系。 假设 3：睡眠中断的受试者在清醒和/或睡眠期间血压会升高， 与睡眠不足的类型和严重程度相称，并受到性别和年龄等因素的调节。 该提案的预期结果将是一个结合 NIMHD 研究的机械途径 识别介导睡眠不足的社会心理、行为、背景和生物因素的框架 以及血压的相关增加，从而导致高血压风险，从而解决重要的知识 在了解索马里裔美国人与睡眠相关的健康差异及其后果方面存在差距。