Disrupted Sleep in Somali Americans – Implications for Hypertension Risk

索马里裔美国人的睡眠中断 — 对高血压风险的影响

• 批准号: 10518658
• 负责人: Virend K Somers
• 金额: $ 78.72万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-10 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10518658
• 关键词: Address; Advisory Committees; Africa; African ancestry; Age; American; Amphetamines; Behavior; Behavioral; Biological; Biological Factors; Black Populations; Blood Pressure; Cardiovascular Diseases; Central obesity; Clinic; Collaborations; Communities; Consumption; Data; Diabetes Mellitus; Diagnosis; Disease; Dislocations; Drowsiness; Environmental Risk Factor; Epidemic; Future; Genotype; Geography; Health; Health Disparities Research; Health Priorities; High Prevalence; Hour; Hypertension; Immigrant; Immigrant community; Immigration; Individual; Intervention; Knowledge; Language; Measures; Mediating; Mediator of activation protein; Metabolic Diseases; Metabolic syndrome; Minnesota; Modeling; National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; Neighborhoods; Obstructive Sleep Apnea; Outcome; Pathway interactions; Patients; Physical activity; Play; Polysomnography; Population; Positioning Attribute; Prevention; Process; Public Health; Refugee Camp; Reporting; Research; Research Priority; Risk; Risk Factors; Role; Services; Severities; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Social Work; Sodium Chloride; Stimulant; Strategic vision; Stress; Sum; Time; Translating; Visceral fat; Wakefulness; base; blood pressure elevation; cardiovascular disorder risk; cardiovascular health; community based participatory research; comorbidity; contextual factors; experience; health disparity; high risk; hypertensive; innovation; insight; interdisciplinary approach; obesity risk; patient engagement; physical inactivity; poor sleep; prevent; protective factors; psychological distress; psychosocial; psychosocial stressors; racism; recruit; salt intake; screening; sex; sleep abnormalities; social culture; socioeconomic disadvantage; volunteer

Disrupted sleep, a major public health issue, independently increases risk for cardiovascular disease (CVD). Blacks have increased rates of sleep deficiency, which are likely under-reported. Importantly, these data relate primarily to those of West African ancestry. Our current knowledge of sleep disruption in Blacks, already severely limited in scope, cannot be readily applied to Somali Americans. The majority of Somali immigrants have settled in Minnesota, placing our Minnesota-based research team in a unique position to comprehensively study the mechanisms and consequences of disrupted sleep as a mediator of cardiovascular health disparities in this population. Our preliminary data suggest that Somali Americans have a high likelihood of disrupted sleep, which may put them at increased risk for hypertension and other CVD. Underlying sociocultural, behavioral, environmental and biological factors likely contribute to an increased risk for sleep deficiencies. We therefore propose an inter-disciplinary approach using a socioecological model informed by the National Institute on Minority Health and Health Disparities (NIMHD) Research Framework to determine the types and severity of undiagnosed sleep deficiencies in otherwise healthy Somali Americans, identify mechanisms contributing to their disrupted sleep, and examine the role of sleep deficiencies in raising blood pressure (BP). Our central hypothesis is that Somali Americans will have a high likelihood of sleep deficiencies attributable in part to unique multilevel individual, psychosocial, contextual and behavioral factors, which exert deleterious biological effects. We propose the following aims: Aim 1: Determine the types and severity of previously undiagnosed sleep deficiencies in otherwise healthy Somali Americans. Hypothesis 1: Somali Americans have a high (>50%) likelihood of previously undiagnosed sleep deficiencies (short sleep (<6 hours), insomnia and obstructive sleep apnea). Aim 2: Apply the NIMHD Research Framework to define psychosocial, behavioral, environmental and biological mechanisms mediating sleep deficiencies in Somali Americans. Hypothesis 2: Unique multilevel individual, cultural and environmental risk and protective factors play a mechanistic role in mediating an increased likelihood of disrupted sleep in Somali Americans. Aim 3: Examine the relationship between sleep deficiencies and increased BP in Somali Americans. Hypothesis 3: BP during wakefulness and/or sleep will be increased in those subjects with disrupted sleep, commensurate with type and severity of sleep deficiency, and moderated by factors such as sex and age. The expected outcome of this proposal will be a mechanistic pathway incorporating the NIMHD Research Framework to identify psychosocial, behavioral, contextual and biological factors mediating sleep deficiencies and related increases in BP, and consequently hypertension risk, thus addressing important knowledge gaps in understanding sleep-related health disparities and their consequences in Somali Americans.

睡眠中断，这是一个重大的公共卫生问题，独立增加了心血管疾病的风险 （CVD）。黑人的睡眠不足率增加了，这可能是报道不足的。重要的是，这些 数据主要与西非血统有关。我们目前对黑人睡眠中断的了解， 已经严重限制了范围，不能容易地应用于索马里美国人。大多数索马里 移民已经定居在明尼苏达州，使我们的明尼苏达州的研究团队处于独特的位置 全面研究破坏睡眠的机制和后果，作为心血管的介体 该人群的健康差异。我们的初步数据表明，索马里美国人的可能性很大 睡眠中断，这可能会使他们面临高血压和其他CVD的风险。潜在的 社会文化，行为，环境和生物学因素可能导致睡眠风险增加 缺陷。因此，我们使用社会生态模型提出了跨学科的方法 由美国国家少数民族健康与健康差异（NIMHD）研究的信息 确定未诊断睡眠不足的类型和严重性的框架 索马里美国人，确定导致睡眠中断的机制，并检查 升高血压（BP）的睡眠不足。我们的中心假设是索马里美国人将 睡眠不足的可能性很大，部分原因是独特的多层次个体，心理社会， 上下文和行为因素，产生有害的生物学作用。我们提出以下目标： 目标1：确定以前未诊断的睡眠不足的类型和严重性 健康的索马里美国人。假设1：索马里美国人以前的可能性很高（> 50％） 无法诊断的睡眠不足（睡眠短（<6小时），失眠和阻塞性睡眠呼吸暂停）。 目标2：应用NIMHD研究框架来定义社会心理，行为，环境和环境 介导索马里美国人睡眠不足的生物学机制。假设2：独特 多层次的个人，文化和环境风险以及保护因素在 调解索马里美国人睡眠中断的可能性增加。 目标3：检查索马里美国人的睡眠不足与BP增加之间的关系。 假设3：在觉醒和/或睡眠期间的BP将在睡眠中断的受试者中增加 与睡眠不足的类型和严重程度相称，并由性和年龄等因素进行调节。 该提案的预期结果将是结合NIMHD研究的机械途径 识别介导睡眠不足的社会心理，行为，上下文和生物学因素的框架 BP的相关增加以及因此高血压风险，从而解决了重要的知识 了解与睡眠有关的健康差异及其在索马里美国人中的后果的差距。