Dissecting the in vivo stromal metabolic and inflammatory crosstalk in colorectal cancer

剖析结直肠癌的体内基质代谢和炎症串扰

• 批准号: 10517637
• 负责人: Maria Angeles Duran Molina
• 金额: $ 17.78万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-16 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517637
• 关键词: Area; Award; Bioinformatics; Biology; Cancer Biology; Cells; Colorectal Cancer; Complex; Dedications; Desmoplastic; Funding; Grant; Inflammation; Inflammatory; Knowledge; Laboratories; Malignant Neoplasms; Medicine; Mesenchymal; Metabolic; Metabolism; Modeling; Molecular; Pathology; Process; Prognosis; Research; Role; Scientist; Seminal; Signal Transduction; Specialist; Technical Expertise; Time; Training; Wages; bioinformatics tool; cancer type; design; effective therapy; human disease; in vivo; in vivo Model; mouse model; new therapeutic target; novel; programs; success; tumor microenvironment; tumor progression

SUMMARY This proposal seeks Dr. Angeles Duran’s salary support as a Research Specialist to support Dr. Jorge Moscat’s research program at the Weill Cornell Medicine Department of Pathology and Laboratory Medicine to study the role of the tumor microenvironment (TME) in colorectal cancer (CRC). Dissecting the role of these complex cellular interactions requires scientists with an in-depth understanding of the biology of these processes, but also with the required technical expertise in in vivo mouse models that faithfully recapitulate human disease, as well as the necessary bioinformatics tools to interrogate the TME of these models at the single-cell level. Therefore, with this Research Specialist Award, we intend to provide stable research opportunities for the exceptional scientist, Angeles Duran, to develop impactful research in this area of expertise. She has made seminal contributions in signaling, inflammation, metabolism and cancer and has a strong interdisciplinary training that will be critical for the success of the project. She will contribute to the research program focused on defining the molecular and cellular mechanisms that drives mesenchymal CRC, a desmoplastic and of poor prognosis type of cancer. With her expertise in cancer biology and her capacity to apply novel mouse models and bioinformatics approaches, she is filling a unique niche within the Moscat lab that will provide continuity, stability, and detailed scientific knowledge to achieve the aims of the NCI-funded grants. She will support this project with scientifically impactful in vivo models and bioinformatics approaches. Dr. Duran’s long-time expertise and dedication will advance our understanding of the role of TME in cancer progression to help design more effective therapies.

概括 该提案寻求安吉尔斯·杜兰博士的薪水支持，作为支持豪尔赫·莫斯特博士的研究专家 Weill Cornell医学部病理学和实验室医学研究计划，研究 肿瘤微环境（TME）在结直肠癌（CRC）中的作用。解剖这些复杂的作用 细胞相互作用需要科学家对这些过程的生物学有深入的了解，也需要 具有忠实地概括人类疾病的体内小鼠模型中所需的技术专业知识 作为在单细胞级别询问这些模型TME的必要生物信息学工具。所以， 通过该研究专家奖，我们打算为卓越的研究机会提供稳定的研究机会 科学家安吉尔斯·杜兰（Angeles Duran）在这一专业知识领域进行了有影响力的研究。她已经开创了 信号传导，感染，代谢和癌症的贡献，并进行了强大的跨学科培训 对于项目的成功至关重要。她将为重点定义的研究计划做出贡献 驱动间充质CRC的分子和细胞机制，一种脱层和预后不良的类型 癌症。凭借她在癌症生物学方面的专业知识以及应用新颖的鼠标模型和生物信息学的能力 方法是，她在莫斯特实验室内填补了一个独特的利基市场，该利基将提供连续性，稳定和详细 科学知识以实现NCI资助的赠款的目标。她将科学支持这个项目 在体内模型和生物信息学方法中有影响力。杜兰博士的长期专业知识和奉献精神将 促进我们对TME在癌症进展中的作用以帮助设计更有效疗法的理解。