Midcareer Investigator Award in Patient-Oriented Research in Pediatric Asthma

以患者为导向的小儿哮喘研究中职业生涯研究者奖

基本信息

批准号：
10512564
负责人：
KECIA Nicole CARROLL
金额：
$ 11.17万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-01 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10512564
关键词：
Academic Medical Centers Address Adult Age Anti-Inflammatory Agents Antioxidants Asthma Award Body mass index Breast Feeding Child Child Health Childhood Childhood Asthma Chronic Classification Clinical Clinical Data Clinical Investigator Clinical Research Data Data Sources Development Diabetes Mellitus Disease Disease Outcome Effectiveness Electronic Health Record Environment Epidemiologist Exposure to Faculty Fellowship Fetus Fostering Funding Future Gestational Age Growth Immune system Immunologics Infant Inflammatory Investigation K-Series Research Career Programs Lead Life Link Lung Mentors Metabolic Midcareer Investigator Award in Patient-Oriented Research Morbidity - disease rate Mothers National Institute of Allergy and Infectious Disease Nutritional Outcome Oxidative Stress Pediatrics Play Policies Pregnancy Prevention Prospective Studies Prospective cohort Publications Pulmonology Research Research Design Research Personnel Risk Risk Factors Role Site Time Training Universities Wheezing asthma prevention career cohort comorbidity cost efficient experience gestational weight gain high risk immune health in utero interest lung health maternal diabetes mid-career faculty novel offspring patient oriented patient oriented research pediatrician prenatal prenatal exposure prenatal risk factor prepregnancy prepregnancy obesity programs prospective pulmonary function recruit respiratory health response secondary analysis skills smoking during pregnancy translational study traumatic stress

项目摘要

The candidate is currently an Associate Professor of Pediatrics at Vanderbilt University and a clinical investigator and epidemiologist whose research investigations are thematically linked through their focus on delineating prenatal and early life determinants of asthma and lung function to inform efforts to increase protective exposures, decrease adverse exposures, and inform prevention efforts. Prenatal exposures, such as diabetes during pregnancy, have the potential to have lifelong effects on respiratory health through associated systemic inflammatory, immunologic, or oxidative stress changes that influence the developing pulmonary or immune system of the fetus. The candidate’s current patient-oriented research investigations include prenatal exposures such as maternal traumatic stress, antioxidant and anti-inflammatory nutritional exposures, and oxidative stress, and she proposes to expand to investigations of diabetes during pregnancy and child asthma and lung function in prospective and novel cohorts of mother-child dyads. The candidate has developed a plan to increase and strengthen her skills in both patient-oriented research and mentoring to include formal research mentor training. The candidate proposes a mentoring plan for trainees to facilitate their effective transition from junior clinical investigator to independent investigators.

该候选人目前是范德比尔特大学的儿科协会教授和临床研究者和流行病学家的研究调查从主题上关注描述哮喘和肺功能的产前和早期生命决定因素，以告知努力增加保护性暴露，减少不良暴露并为预防工作提供信息。作为怀孕期间的糖尿病，有可能通过相关的全身性炎症，免疫或氧化应激发生了变化胎儿的肺部或免疫系统。包括产前暴露，例如母体创伤性应力，抗氧化剂和Andi-Inflammature nutritional 暴露和氧化应激，她建议在怀孕期间扩展到糖尿病的研究儿童哮喘和肺在前瞻性和新颖的母子二元组中的前瞻性制定了一项计划，以提高和力量力量的力量增强了她在以患者为导向的研究和指导中的技能包括正式的研究导师培训。从初级临床研究者到独立研究人员的有效过渡。