Internet-based insomnia intervention to prevent cognitive decline in older adults with mild cognitive impairment

基于互联网的失眠干预预防轻度认知障碍老年人认知能力下降

• 批准号: 10512305
• 负责人: Meghan K Mattos
• 金额: $ 24.3万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10512305
• 关键词: Adult; Advertisements; Affect; Aging; Alzheimer' s Disease; Attention; Chronic Disease; Chronic Insomnia; Clinical; Clinical Trials; Clinical Trials Design; Cognition; Cognitive; Cognitive Therapy; Collection; Coupled; Development; Disease; Elderly; Fatigue; Feeling; Funding; Future; Geriatric Nursing; Gerontology; Goals; Health; Hour; Impaired cognition; Impairment; Individual; International; Internet; Intervention; K-Series Research Career Programs; Leadership; Left; Measures; Memory; Mentorship; Methods; Moods; Neuropsychology; Nurses; Outcome; Participant; Patient Care; Patient Education; Patient Recruitments; Patients; Personal Satisfaction; Persons; Pharmacology; Population; Populations at Risk; Positioning Attribute; Provider; Psychomotor Performance; Public Health; Quality of life; Randomized Controlled Trials; Recording of previous events; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Role; Science; Scientist; Severities; Sleep; Sleep Disorders; Sleeplessness; Speed; Symptoms; Time; Training; Translating; Travel; Universities; Virginia; Work; acceptability and feasibility; adverse outcome; arm; base; career; cognitive performance; comparison intervention; dementia care; digital health; digital treatment; efficacy evaluation; efficacy testing; executive function; experience; falls; follow-up; health assessment; improved; innovation; instrument; intervention effect; mild cognitive impairment; nervous system disorder; post intervention; preservation; prevent; programs; randomized trial; recruit; sleep onset; social networking website; success; trial design

Dr. Meghan Mattos is a nurse scientist with training in gerontological nursing, dementia care and management, sleep disorders, and digital health combined with clinical expertise in the care of patients with neurological disorders. Her current research, research funding, and history of dissemination demonstrate her ability to execute innovative, impactful research in older adults with cognitive impairment, specifically to improve quality of life and disease trajectory. Dr. Mattos’s short-term career goals are to become an independent nurse researcher focused on the use of digital health in older adults and grow as a leader through additional formal leadership training. Her broad, long-term career goal is to implement effective, accessible interventions via the Internet for older adults to maintain cognitive health and well-being. The training and mentorship afforded by the NIA Beeson Career Development Award in Aging will allow her to gain expertise and receive mentorship in the conduct of rigorous Alzheimer’s disease trials using digital therapeutics and Internet-based recruitment methods. This project will be conducted under the outstanding and complimentary mentorship of an international leader in digital health and Internet-based recruitment (Dr. Lee Ritterband), leader in the assessment of health outcomes in aging and chronic disease (Dr. Steven Albert), and nurse innovator and leader in cognitive impairment (Dr. Jennifer Lingler). The University of Virginia is committed to Dr. Mattos’s development as a nurse scientist working in team science and provides the necessary facilities and resources to conduct the proposed research project. Building upon Dr. Mattos and her team’s preliminary work, the proposed randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals with mild cognitive impairment. Participants with insomnia who meet the study criteria for mild cognitive impairment will be recruited to determine the effects of the CBT-I intervention compared to a patient education control condition on sleep and cognition. Internet-based recruitment methods will be used, and outcomes include sleep variables (reduced overall insomnia severity and wake after sleep onset), daytime variables (reduced levels of fatigue, improved quality of life, and improved mood), and cognitive status (memory, attention/psychomotor speed, and executive functioning domains). This proposal will inform a future randomized controlled trial powered to detect the intervention effect on the slope of cognitive decline as well as provide Dr. Mattos training in 1) the conduct of rigorous and reproducible trials and 2) leading recruitment efforts using Internet-based settings and conducting digital health trials in older adults. The Beeson Career Development Award in Aging will allow Dr. Mattos to engage in formal opportunities for leadership at the national and international levels to advance gerontological nursing and establish her independent career in digital health for older adults with cognitive impairment.

梅根·马托斯（Meghan Mattos）博士是一位护士科学家，接受了老年医学护士，痴呆护理和管理培训， 睡眠障碍和数字健康以及神经系统患者护理的临床专业知识 疾病。她目前的研究，研究资金和传播历史证明了她的能力 在认知障碍的老年人中执行创新，有影响力的研究，特别是为了提高质量 生命和疾病轨迹。 Mattos博士的短期职业目标是成为一名独立护士 研究人员专注于在老年人中使用数字健康，并通过额外的正式成长为领导者 领导力培训。她广泛的长期职业目标是通过 老年人维持认知健康和福祉的互联网。提供的培训和精神制。 Nia Beeson老龄化职业发展奖将使她获得专业知识并获得精神训练 使用数字疗法和基于互联网的招聘进行严格的阿尔茨海默氏病试验的行为 方法。该项目将在一个未杰出和免费的指导下进行 国际数字健康和基于Internet的招聘（Lee Ritterband博士）的国际领导者 评估衰老和慢性病（史蒂文·艾伯特博士）和护士创新者的健康结果和 认知障碍的领导者（詹妮弗·林格尔博士）。弗吉尼亚大学致力于Mattos博士的 作为护士科学家的发展，从事团队科学工作，并提供必要的设施和资源 进行拟议的研究项目。在Mattos博士及其团队的初步工作的基础上 拟议的随机对照试验将评估互联网传递的认知行为的影响 失眠治疗（CBT-I）对睡眠的干预及其对认知健康的程度 患有轻度认知障碍的人。失眠的参与者符合中期的学习标准 与患者相比，将招募认知障碍以确定CBT-I干预的影响 教育控制条件在睡眠和认知方面。将使用基于互联网的招聘方法，并且 结果包括睡眠变量（减少整体失眠严重程度和睡眠后醒来），白天 变量（疲劳水平降低，改善生活质量和情绪改善）和认知状况 （记忆，注意力/心理速度和执行功能域）。该建议将为未来提供信息 随机对照试验供应检测对认知下降斜率的干预效果以及 在1）进行严格且可重复的试验的行为和2）领导招聘 使用基于互联网的设置并在老年人中进行数字健康试验的努力。贝森职业 衰老发展奖 将允许Mattos博士 在领导领导的正式机会 国家和国际级别的促进老年医学护士并建立她的独立职业 具有认知障碍的老年人的数字健康。