Establishing a NI-centric supply chain for a Novel At-line IgG Titre System

为新型在线 IgG 滴度系统建立以 NI 为中心的供应链

• 批准号: 10106193
• 金额: $ 12.52万
• 依托单位: CAUSEWAY SENSORS LIMITED
• 依托单位国家: 英国
• 项目类别: Launchpad
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10106193
• 关键词: Establishing; NI; centric; supply; chain; Establishing; NI; centric; supply; chain

Causeway Sensors is undertaking a project to develop Titan, an advanced sensor platform for integrating into bioreactors that allows real-time monitoring of critical quality attributes in biotherapeutics manufacturing.The Titan system comprises an instrument and a proprietary reagent kit featuring a consumable nanosensor chip for precise and efficient monitoring of IgG titre during the manufacturing and purification of monoclonal antibody-based therapeutics. The reagents kit is a critical component of the commercial offering, facilitating standard curve generation, regeneration solutions to allow multiple sample analyses per chip and instrument cleaning.The project's primary objective is to establish a local supply chain to produce Titan test kits. Causeway will use subcontractors to carry out critical elements of the kit assembly process. Fusion Antibodies, world experts in antibody production, will manufacture and purify an IgG1 monoclonal antibody, which will be used as the standard in the Titan test kits. Fortress Diagnostics, a leading diagnostics company, will be used for its freeze-drying and kit assembly expertise.The project aims to generate real-time data by monitoring antibody production and purification processes at Fusion Antibodies. This data will be used to create application notes and technical documentation for Titan, providing valuable insights into its performance and applications.Causeway Sensors anticipates that Titan will significantly impact biopharmaceutical manufacturing, introducing advanced process analytical testing (PAT) sensors for more efficient and data-informed manufacturing of biotherapeutics. The project reflects our commitment to local collaboration and expertise development in this field, contributing to increased activity in Northern Ireland's growing Life Sciences sector.

堤道传感器正在进行一个开发泰坦的项目，这是一个先进的传感器平台，用于整合生物反应器，允许对生物治疗剂制造中的关键质量属性进行实时监控。泰坦系统包括一种仪器和专有的试剂盒，具有可消耗量的纳米传感器芯片，以对IGG造成的Ig the Ig thronefifient and Putrication the Manductive the Manductive and Pretifution the Manductive the Manductive the Mandution throne prefitiate prefient the Manduction throne prefient。试剂套件是商业产品的关键组成部分，促进标准曲线的产生，再生解决方案，以允许每个芯片和仪器清洁进行多次样品分析。该项目的主要目标是建立一个本地供应链来生产泰坦测试套件。 Causeway将使用分包商来执行套件组装过程的关键要素。融合抗体是抗体生产的世界专家，将制造和纯化IgG1单克隆抗体，该抗体将用作泰坦测试套件的标准。领先的诊断公司Fortress Diagnostics将用于冻干和套件组装专业知识。该项目旨在通过监测融合抗体的抗体生产和纯化过程来生成实时数据。该数据将用于为泰坦（Titan）创建应用笔记和技术文档，提供对其性能和应用程序的宝贵见解。Causeway传感器预计泰坦将显着影响生物制药制造业，从而引入高级过程分析测试（PAT）传感器，以提供更有效的生物治疗制造和数据形成生产的生产。该项目反映了我们对该领域的当地合作和专业知识发展的承诺，这有助于增加北爱尔兰不断增长的生命科学领域的活动。