Mechanistic registry to study whether infection with Corona Virus Disease 2019 (COVID-19) accelerates atherosclerotic plaque progression
研究 2019 年冠状病毒病 (COVID-19) 感染是否加速动脉粥样硬化斑块进展的机制登记
基本信息
- 批准号:10558896
- 负责人:
- 金额:$ 150.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Project Summary / Abstract
The primary objective of the corona virus disease 2019 (COVID-19) (COVID-CT) registry is to determine if
infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus which causes
COVID-19, results in marked progression of coronary atherosclerotic plaque in patients with previously defined
anatomic coronary artery disease (CAD). COVID-19 induces a pro-inflammatory cytokine release and pro-
thrombotic processes that we hypothesize will accelerate atherosclerotic plaque progression. Coronary
computed tomographic angiography (CCTA) is a robust noninvasive method uniquely capable of measuring
angiographic stenosis and quantifying and characterizing atherosclerotic plaque. Our group has extensive
experience in large multicenter trials and registries using CCTA to identify key atherosclerotic plaque features
associated with progression and major CAD events. Moreover, we propose use of a novel CT marker of coronary
artery inflammation - the perivascular fat attenuation index (FAI) – a marker highly predictive of acute CAD events
and to assess serial changes in coronary inflammation.
COVID-19 is rapidly becoming a leading cause of death with substantial evidence that pre-existing CAD
increases risk of serious illness and mortality from COVID-19. By enrolling patients with high risk, atherosclerotic
plaque, findings from the COVID-CT registry will inform this link between the inflammatory response sustained
during COVID-19 to accelerated atherosclerotic plaque progression. If our hypotheses are confirmed, then
clinicians and patients will have clear information that viral infections, such as SARS-CoV-2, alter the
inflammatory milieu and accelerate progression of atherosclerosis. Importantly, a connection between COVID-
19 and CAD will broadly impact preventive risk assessment for the ~7 million patients infected with SARS-CoV-
2 and millions more yet to be tested in the United States.
To date, evidence is lacking as to whether the COVID-19 results in marked atherosclerotic plaque progression
among racially and ethnically diverse patients with CCTA-defined CAD who reside across a socioeconomically-
diverse, urban setting. The present proposal constitutes a comprehensive approach assessing the clinical
importance of atherosclerotic plaque progression following COVID-19. Currently, the implications of epicardial
coronary injury following SARS-CoV-2 infection is unknown. Yet, the inflammatory pathway of atherosclerotic
plaque progression is well studied and, as such, our hypotheses are supported by this knowledge base. The
proposed COVID-19 registry is poised to provide an improved mechanistic understanding of the role of viral
infection on alterations in atherosclerotic plaque.
项目概要/摘要
2019 年冠状病毒病 (COVID-19) (COVID-CT) 登记的主要目标是确定是否
感染严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2),该病毒会导致
COVID-19导致先前定义的患者冠状动脉粥样硬化斑块显着进展
冠状动脉疾病 (CAD) 会诱导促炎细胞因子释放和促炎细胞因子释放。
我们所追求的血栓形成过程将加速冠状动脉粥样硬化斑块的进展。
计算机断层扫描血管造影 (CCTA) 是一种强大的无创方法,能够独特地测量
血管造影狭窄以及量化和表征动脉粥样硬化斑块。
使用 CCTA 识别关键动脉粥样硬化斑块特征的大型多中心试验和注册经验
此外,我们建议使用一种新型冠状动脉 CT 标记物。
动脉炎症 - 血管周围脂肪衰减指数 (FAI) - 高度预测急性 CAD 事件的标志物
并评估冠状动脉炎症的连续变化。
COVID-19 正迅速成为主要死亡原因,有大量证据表明先前存在 CAD
通过招募患有动脉粥样硬化的高风险患者,会增加因 COVID-19 导致严重疾病和死亡的风险。
斑块,COVID-CT 登记的结果将揭示持续的炎症反应之间的联系
在 COVID-19 期间加速动脉粥样硬化斑块的进展 如果我们的假设得到证实,那么
前沿和患者将获得明确的信息,即病毒感染(例如 SARS-CoV-2)会改变
重要的是,新冠肺炎之间存在联系。
19 和 CAD 将广泛影响约 700 万感染 SARS-CoV 的患者的预防风险评估
2 以及还有数百万人有待在美国进行测试。
迄今为止,尚缺乏证据表明 COVID-19 是否会导致明显的动脉粥样硬化斑块进展
患有 CCTA 定义的 CAD 的不同种族和族裔患者,他们居住在不同的社会经济地位
本提案构成了评估临床的综合方法。
COVID-19 后动脉粥样硬化斑块进展的重要性 目前,心外膜的影响。
SARS-CoV-2 感染后冠状动脉损伤的机制尚不清楚,但动脉粥样硬化的炎症途径尚不清楚。
斑块进展已得到充分研究,因此,我们的假设得到了该知识库的支持。
拟议的 COVID-19 登记处旨在提供对病毒作用的更好的机制理解
感染对动脉粥样硬化斑块变化的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JAGAT NARULA', 18)}}的其他基金
Mechanistic registry to study whether infection with Corona Virus Disease 2019 (COVID-19) accelerates atherosclerotic plaque progression
研究 2019 年冠状病毒病 (COVID-19) 感染是否加速动脉粥样硬化斑块进展的机制登记
- 批准号:
10482402 - 财政年份:2022
- 资助金额:
$ 150.63万 - 项目类别:
Mechanistic registry to study whether infection with Corona Virus Disease 2019 (COVID-19) alters atherosclerotic plaque progression
研究 2019 年冠状病毒病 (COVID-19) 感染是否会改变动脉粥样硬化斑块进展的机制登记
- 批准号:
10280423 - 财政年份:2021
- 资助金额:
$ 150.63万 - 项目类别:
Targeting MMPS to Image Atherosclerosis
以 MMPS 为目标进行动脉粥样硬化成像
- 批准号:
6950782 - 财政年份:2004
- 资助金额:
$ 150.63万 - 项目类别:
Targeting MMPS to Image Atherosclerosis
以 MMPS 为目标进行动脉粥样硬化成像
- 批准号:
7269390 - 财政年份:2004
- 资助金额:
$ 150.63万 - 项目类别:
Targeting MMPS to Image Atherosclerosis
以 MMPS 为目标进行动脉粥样硬化成像
- 批准号:
6848199 - 财政年份:2004
- 资助金额:
$ 150.63万 - 项目类别:
Targeting MMPS to Image Atherosclerosis
以 MMPS 为目标进行动脉粥样硬化成像
- 批准号:
7117641 - 财政年份:2004
- 资助金额:
$ 150.63万 - 项目类别:
Imaging Apoptosis to Detect Unstable Atheromatous Plaque
细胞凋亡成像检测不稳定的粥样斑块
- 批准号:
6686786 - 财政年份:2002
- 资助金额:
$ 150.63万 - 项目类别:
Imaging Apoptosis to Detect Unstable Atheromatous Plaque
细胞凋亡成像检测不稳定的粥样斑块
- 批准号:
6418408 - 财政年份:2002
- 资助金额:
$ 150.63万 - 项目类别:
Imaging Apoptosis to Detect Unstable Atheromatous Plaque
细胞凋亡成像检测不稳定的粥样斑块
- 批准号:
6620504 - 财政年份:2002
- 资助金额:
$ 150.63万 - 项目类别:
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