Integrating the Social Context, Sensory Functioning, and Inflammation in a Longitudinal Study of Cognitive Aging and Alzheimer's Disease and Related Dementias

将社会环境、感觉功能和炎症纳入认知衰老和阿尔茨海默病及相关痴呆症的纵向研究

• 批准号: 10505959
• 负责人: Alyssa Goldman
• 金额: $ 12.65万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505959
• 关键词: Age-associated memory impairment; Aging; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Area; Award; Biological; Brain; Buffers; Chronic; Cognition; Cognitive; Cognitive aging; Data; Development; Diagnosis; Disease; Distal; Elderly; Exposure to; Family; Future; Goals; Grant; Health; Home; Impaired cognition; Inflammation; Inflammatory Response; Infrastructure; Intervention; Knowledge; Lead; Life; Light; Link; Longitudinal Studies; Measures; Mentored Research Scientist Development Award; Mentorship; Methods; Neighborhoods; Pathway interactions; Patients; Physiological; Physiology; Population Study; Prevalence; Process; Public Health; Research; Research Activity; Research Design; Research Personnel; Risk; Role; Sampling; Sensory; Shapes; Site; Smell Perception; Social Characteristics; Social Environment; Social Network; Social support; Source; Survey Methodology; Time; Training; Training Activity; United States; Vision; Work; Writing; age related; analytical method; burden of illness; career; cognitive ability; cognitive function; experience; improved; innovation; insight; longitudinal analysis; middle age; novel; prevent; programs; rapid growth; sensory system; skills; social; social determinants; social factors; social learning; social relationships; social science research; sociologist; training project

PROJECT SUMMARY/ABSTRACT Research into cognitive impairments and Alzheimer’s disease and related dementias (ADRD) suggests that exposure to enriching or stimulating social contexts – i.e., social complexity – may slow age-related cognitive decline and delay the onset or progression of ADRD. Most research in this area has considered how social complexity in either the proximal (e.g., social network, social activities) or distal (e.g., neighborhood) contexts shape cognition. Additionally, prior research on social complexity and cognition is conducted largely separately from existing physiological frameworks for understanding cognitive aging and ADRD. Through this K01, Dr. Alyssa Goldman will integrate existing research on the roles of sensory systems and inflammation in shaping cognitive decline and ADRD, and examine how these associations are informed by changes in both proximal and distal social complexity over time. Dr. Goldman’s long-term goal is to lead a social science research program that uses innovative approaches to better understand the social pathways of cognitive functioning and ADRD. The K01 Award will support this goal by extending her prior training as a sociologist, developing her understanding of and skills in: (1) the physiology of cognitive aging, ADRD, sensory functioning, and inflammation, (2) the objective assessment of cognition, sensory functioning, and inflammation through large- scale, in-home survey methods, (3) advanced methods for longitudinal analysis, and (4) grant writing and professional development. In parallel with this training, this project has three research aims: (1) to determine how changes in exposure to proximal and distal social complexity collectively shape cognition and ADRD, (2) to determine how proximal and distal social complexity are associated with olfaction, in ways that may shape trajectories of cognition and ADRD, and (3) to determine how proximal and distal social complexity are associated with inflammation, in ways that may explain changes in cognition and ADRD. The training and research goals of this proposal will be overseen by a mentorship committee of accomplished experts in cognition and ADRD, sensory systems, chronic inflammation, and aging and the social context. This study will generate new insights on the collective impact of proximal and distal social factors on cognitive decline and ADRD. Further, this study will examine how social complexity shapes trajectories of olfaction and inflammation as mechanisms in the relationship between social complexity and cognitive health in a nationally-representative sample of older adults. These physiological frameworks of cognition and ADRD have yet to be contextualized in terms of social factors. This study will develop innovative measures of social network change, which are largely undertheorized, and that can be applied to future studies of cognitive aging and other health trajectories. The training and research activities of this award will equip Dr. Goldman with the skills to succeed as an independent investigator of the social context of sensory systems, disease processes, and their relationships with cognition and ADRD.

项目摘要/摘要 认知障碍以及阿尔茨海默氏病和相关痴呆症（ADRD）的研究表明， 暴露于丰富或刺激社会环境（即社会复杂性）可能会减慢与年龄有关的认知能力 衰落并延迟ADRD的发作或进展。该领域的大多数研究都考虑了如何社交 近端（例如社交网络，社交活动）或远端（例如，邻里）上下文的复杂性 形状认知。此外，对社会复杂性和认知的先前研究很大程度上是分开进行的 从现有的物理框架中理解认知衰老和ADRD。通过这个K01，博士 Alyssa Goldman将整合有关感觉系统角色和注射在塑造中的作用的现有研究 认知能力下降和ADRD，并检查如何通过两种近端变化来告知这些关联 随着时间的流逝，社会复杂性。高盛博士的长期目标是领导社会科学研究计划 这种使用创新的方法可以更好地了解认知功能和ADRD的社会途径。 K01奖将通过扩大她的社会学家的培训来支持这一目标，并发展她 理解和技能：（1）认知衰老，ADRD，感觉功能和 炎症，（2）通过大型认知，感觉功能和炎症的客观评估 比例尺，家庭调查方法，（3）用于纵向分析的高级方法以及（4）授予写作和 专业发展。与该培训同时，该项目具有三个研究目的：（1）确定 暴露于近端和盘点社会复杂性的变化如何共同塑造认知和ADRD，（2） 确定近端和远端社会复杂性与嗅觉相关，以可能形成的方式 认知和ADRD的轨迹，以及（3）确定近端和盘点的社会复杂性 与炎症相关，可以解释认知和ADRD的变化。培训和 该提案的研究目标将由有成就的认知专家的精通委员会监督 和ADRD，感官系统，慢性感染以及衰老和社会环境。这项研究将产生 对近端和盘点社会因素对认知能力下降和ADRD的集体影响的新见解。更远， 这项研究将研究社会复杂性如何形成嗅觉和注入的轨迹作为机制 在全国代表性的老年样本中，社会复杂性与认知健康之间的关系 成年人。这些认知和ADRD的物理框架尚未从社会上进行背景化 因素。这项研究将制定社交网络变化的创新度量，这些措施在很大程度上是理论上的， 这可以应用于对认知衰老和其他健康轨迹的未来研究。培训和 该奖项的研究活动将使高盛（Goldman）能够成功成为独立研究者的技能 感官体系，疾病过程的社会背景及其与认知和ADRD的关系。