CAP-IT CRI U54 ADMINISTRATIVE CORE

CAP-IT CRI U54 管理核心

• 批准号: 10505676
• 负责人: Steven M Lipkin
• 金额: $ 11.71万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505676
• 关键词: American Association of Cancer Research; American Society of Clinical Oncology; Automobile Driving; Award; Cancer Center; Cancer Research Project; Clinical; Clinical Trials; Collaborations; Contracts; Dana-Farber Cancer Institute; Database Management Systems; Databases; Division of Cancer Prevention; Doctor of Philosophy; Emerging Technologies; Ensure; Evaluation; Genetic Databases; Genomics; Goals; Health Insurance Portability and Accountability Act; Hereditary Nonpolyposis Colorectal Neoplasms; IACUC; Immune Targeting; Immunooncology; Immunoprevention; Individual; Institute of Medicine (U.S.); Institutional Review Boards; International; Journals; Lead; Leadership; Malignant neoplasm of lung; Medicine; Mission; National Cancer Institute; Patients; Prevention Research; Productivity; Program Research Project Grants; RNA; RNA vaccine; Research; Research Personnel; Research Project Grants; Resource Sharing; Role; Site; Time; Translating; Translations; Vaccines; Validation; archive data; cancer prevention; cancer risk; clinical translation; data archive; data management; data sharing; editorial; experience; individualized prevention; meetings; member; pre-clinical; programs; targeted agent; tumor immunology; working group

Admin Core: Project Summary/Abstract A significant overall goal of CAP-IT is to identify and validate immunologically targeted agents for precision prevention of individuals with increased cancer risk. The CAP-IT Center for RNA Immunoprevention (CRI) Administrative Core (AC) mission is to ensure that research project/Core teams maintain focus on this overall goal. The AC will rapidly perform administrative functions that would otherwise serve as rate-limiting bottlenecks, including IRB/IACUC regulatory compliance and the establishment of MTA/DTAs between multiple project sites. The AC will integrate CRI U54 into the CAP-IT network and drive intra-network as well as international collaborations. To ensure CRI's scientific rigor and excellence, we have assembled a scientifically and administratively outstanding CRI External Advisory Board, including the 2021 Lasker Award winner Dr. Drew Weissman (U. Penn). The AC shall also seamlessly integrate genomic databases and emerging technology as shared resources (such as liponanoparticle RNA vaccines and immunopeptidomics) with the CAP-IT U24 DRCC. 1

管理员核心：项目摘要/摘要 CAP-IT的一个重要总体目标是确定和验证以免疫学靶向剂的精度 预防癌症风险增加的个体。 RNA免疫预防（CRI）的CAP-IT中心 行政核心（AC）任务是确保研究项目/核心团队保持关注这一整体 目标。 AC将迅速执行行政功能，否则将用作限制速率的瓶颈， 包括IRB/IACUC调控合规性和在多个项目站点之间建立MTA/DTA。 AC将将CRI U54集成到CAP-IT网络中，并驱动网络内部以及国际 协作。为了确保CRI的科学严谨和卓越，我们已经进行了科学的组合 行政上杰出的CRI外部顾问委员会，包括2021年Lasker奖得主Drew博士 魏斯曼（U. Penn）。 AC还应无缝将基因组数据库和新兴技术整合为 与CAP-IT U24 DRCC共享共享资源（例如Liponanoparticle RNA疫苗和免疫肽组学）。 1