Genetically Informed Studies of Social Connectedness and Health

社会联系与健康的遗传学研究

• 批准号: 10503656
• 负责人: DAVID A SBARRA
• 金额: $ 91.83万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10503656
• 关键词: Address; Adult; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Area; Behavioral Genetics; Biological Aging; Cell Aging; Cognitive; DNA Methylation; Data; Data Collection; Data Set; Dementia; Disease Outcome; Elderly; Epidemiology; Epigenetic Process; Foundations; Grant; Health; Health behavior; Human; Impaired cognition; Individual; Learning; Literature; Loneliness; Marital Status; Marriage; Measures; Memory; Methods; Methylation; Modeling; Monozygotic twins; Morbidity - disease rate; Nature; Neuropsychology; Outcome; Outcome Study; Participant; Pathway interactions; Patient Self-Report; Persons; Phenotype; Records; Registries; Research; Research Design; Research Methodology; Research Personnel; Risk; Sampling; Series; Social Behavior; Social Functioning; Social isolation; Social support; Testing; Time; Twin Multiple Birth; Twin Studies; Variant; Washington; Well in self; Woman; Work; base; cognitive function; cohort; design; epidemiologic data; epigenome-wide association studies; experience; field study; gender difference; indexing; men; middle age; mild cognitive impairment; mood symptom; mortality; neuroimaging; pandemic coronavirus; public health intervention; satisfaction; smartphone Application; social; social integration; social relationships; sound

7. PROJECT SUMMARY A large body of evidence indicates that high-quality social relationships are correlated with decreased risk for morbidity and mortality from a range of disease outcomes, and that social disconnection and poor relationship quality are correlated with considerable risk for negative health outcomes. Although most of the work in this area is correlational in nature, it is often interpreted as if it is causal. Genetically informed research methods can allow researchers to rule-out causal explanations for epidemiological associations and/or identify effects that may be consistent with a causal influence. Using co-twin control methods and a comprehensive new data collection in the Washington State Twin Registry (WSTR), this grant brings together a diverse and established scientific team to examine a series of unanswered questions around social relationships, health, and cognitive functioning, all of which center on causal inference. The work in this proposal is guided by three Specific Aims that will: (1) Conduct a detailed assessment of social relationship functioning in the WSTR and use these variables in co-twin analyses of health and health behaviors. We will conduct a new data collection on 1,000 adult twin pairs (N = 2,000) in the WSTR and complete a “deep phenotyping” of key relationship quality variables, including social integration, relationship satisfaction/quality, and attachment styles. Under Aim 1, we will also collect DNA methylation data and use a series of epigenetic clocks to characterize accelerated biological aging among our main study outcomes; (2) Conduct a detailed neuropsychological assessment of cognitive functioning in the WSTR cohort and use these variables as key outcomes in co-twin models. Social isolation and loneliness may hasten declines in cognitive functioning, but are these associations consistent with a causal effect? We will conduct detailed neuropsychological assessments of the 2,000 WSTR participants using assessments that target cognitive outcomes shown to be associated with accelerated cognitive decline, mild cognitive impairment, and biomarkers of Alzheimer’s disease and related dementias; and (3) Examine the association between objective measures of daily social functioning and the health and cognitive outcomes in the WSTR. The Electronically Activated Recorder (EAR) is a smartphone application that records ambient sounds in participants’ daily lives and provides a means of assessing social behaviors beyond self-report alone. We will collect EAR data from a sub-sample of 140 adult MZ twin pairs discordant for marital status (N = 280) from the WSTR to determine if within twin-pair differences in the objective indices of social integration are associated with the health, health behavior, and cognitive outcomes. Successful completion of the proposed research will help build a causal foundation for public health intervention efforts around social relationships.

7. 项目概要 大量证据表明，高质量的社会关系与降低患病风险相关。 一系列疾病结果导致的发病率和死亡率，以及社会脱节和人际关系不佳 尽管这方面的大部分工作都与质量相关。 领域本质上是相关的，但它通常被解释为因果研究方法。 可以让研究人员排除流行病学关联的因果解释和/或识别影响 这可能与使用双孪生控制方法和全面的新数据一致。 华盛顿州双胞胎登记处 (WSTR) 的收藏，这项赠款汇集了多元化和成熟的 科学团队研究一系列有关社会关系、健康和认知的悬而未决的问题 功能，所有这些都以因果推理为中心。该提案中的工作以三个具体目标为指导。 这将： (1) 对 WSTR 中的社会关系功能进行详细评估并使用 我们将在健康和健康行为的双孪生分析中进行这些变量。 对 WSTR 中的 1,000 对成年双胞胎 (N = 2,000) 进行分析，并完成关键关系的“深度表型分析” 质量变量，包括社会融合、关系满意度/质量和依恋风格。 目标1，我们还将收集DNA甲基化数据并使用一系列表观遗传时钟来表征 我们的主要研究成果之一是加速生物衰老；（2）进行详细的神经心理学研究 评估 WSTR 队列中的认知功能，并使用这些变量作为关键结果 社会孤立和孤独可能会加速认知功能的下降，但这些是吗？ 与因果效应的一致关联？我们将对其进行详细的神经心理学评估 2,000 名 WSTR 参与者使用针对与认知结果相关的评估 加速认知衰退、轻度认知障碍以及阿尔茨海默病和相关疾病的生物标志物 (3) 检查日常社会功能的客观测量与痴呆症之间的关联 WSTR 中的健康和认知结果 电子激活记录仪 (EAR) 是一种 智能手机应用程序可以记录参与者日常生活中的环境声音，并提供一种方法 我们将从 140 名成年人的子样本中收集 EAR 数据。 从 WSTR 中判断婚姻状况不一致的同卵双胞胎 (N = 280) 是否在双胞胎差异之内 社会融合的客观指标与健康、健康行为和认知相关 成功完成拟议的研究将有助于为公共卫生奠定因果基础。 围绕社会关系的干预努力。