Genetically Informed Studies of Social Connectedness and Health

社会联系与健康的遗传学研究

• 批准号: 10503656
• 负责人: DAVID A SBARRA
• 金额: $ 91.83万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10503656
• 关键词: Address; Adult; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Area; Behavioral Genetics; Biological Aging; Cell Aging; Cognitive; DNA Methylation; Data; Data Collection; Data Set; Dementia; Disease Outcome; Elderly; Epidemiology; Epigenetic Process; Foundations; Grant; Health; Health behavior; Human; Impaired cognition; Individual; Learning; Literature; Loneliness; Marital Status; Marriage; Measures; Memory; Methods; Methylation; Modeling; Monozygotic twins; Morbidity - disease rate; Nature; Neuropsychology; Outcome; Outcome Study; Participant; Pathway interactions; Patient Self-Report; Persons; Phenotype; Records; Registries; Research; Research Design; Research Methodology; Research Personnel; Risk; Sampling; Series; Social Behavior; Social Functioning; Social isolation; Social support; Testing; Time; Twin Multiple Birth; Twin Studies; Variant; Washington; Well in self; Woman; Work; base; cognitive function; cohort; design; epidemiologic data; epigenome-wide association studies; experience; field study; gender difference; indexing; men; middle age; mild cognitive impairment; mood symptom; mortality; neuroimaging; pandemic coronavirus; public health intervention; satisfaction; smartphone Application; social; social integration; social relationships; sound

7. PROJECT SUMMARY A large body of evidence indicates that high-quality social relationships are correlated with decreased risk for morbidity and mortality from a range of disease outcomes, and that social disconnection and poor relationship quality are correlated with considerable risk for negative health outcomes. Although most of the work in this area is correlational in nature, it is often interpreted as if it is causal. Genetically informed research methods can allow researchers to rule-out causal explanations for epidemiological associations and/or identify effects that may be consistent with a causal influence. Using co-twin control methods and a comprehensive new data collection in the Washington State Twin Registry (WSTR), this grant brings together a diverse and established scientific team to examine a series of unanswered questions around social relationships, health, and cognitive functioning, all of which center on causal inference. The work in this proposal is guided by three Specific Aims that will: (1) Conduct a detailed assessment of social relationship functioning in the WSTR and use these variables in co-twin analyses of health and health behaviors. We will conduct a new data collection on 1,000 adult twin pairs (N = 2,000) in the WSTR and complete a “deep phenotyping” of key relationship quality variables, including social integration, relationship satisfaction/quality, and attachment styles. Under Aim 1, we will also collect DNA methylation data and use a series of epigenetic clocks to characterize accelerated biological aging among our main study outcomes; (2) Conduct a detailed neuropsychological assessment of cognitive functioning in the WSTR cohort and use these variables as key outcomes in co-twin models. Social isolation and loneliness may hasten declines in cognitive functioning, but are these associations consistent with a causal effect? We will conduct detailed neuropsychological assessments of the 2,000 WSTR participants using assessments that target cognitive outcomes shown to be associated with accelerated cognitive decline, mild cognitive impairment, and biomarkers of Alzheimer’s disease and related dementias; and (3) Examine the association between objective measures of daily social functioning and the health and cognitive outcomes in the WSTR. The Electronically Activated Recorder (EAR) is a smartphone application that records ambient sounds in participants’ daily lives and provides a means of assessing social behaviors beyond self-report alone. We will collect EAR data from a sub-sample of 140 adult MZ twin pairs discordant for marital status (N = 280) from the WSTR to determine if within twin-pair differences in the objective indices of social integration are associated with the health, health behavior, and cognitive outcomes. Successful completion of the proposed research will help build a causal foundation for public health intervention efforts around social relationships.

7。项目摘要 大量证据表明，高质量的社会关系与降低的风险相关 一系列疾病结局的发病率和死亡率，社会断开和关系不佳 质量与对负面健康结果的考虑风险相关。虽然大部分工作 区域本质上是相关的，通常被解释为是因果关系。遗传知情的研究方法 可以允许研究人员排除流行病学关联的因果解释和/或确定影响 这可能与因果影响一致。使用联合双打控制方法和全面的新数据 该赠款在华盛顿州双胞胎注册表（WSTR）中收集，汇集了各种各样的 科学团队研究了有关社会关系，健康和认知的一系列未解决的问题 功能，所有这些都集中在因果推理上。该提案中的工作由三个特定目标指导 这将是：（1）对WSTR中的社会关系功能进行详细评估并使用 这些变量在对健康和健康行为的共同分析中。我们将进行新的数据收集 在WSTR中，在1,000个成年双对（n = 2,000）上，完成了关键关系的“深度表型” 质量变量，包括社会融合，关系满意度/质量和依恋方式。在下面 AIM 1，我们还将收集DNA甲基化数据，并使用一系列表观遗传时钟来表征 我们的主要研究结果中加速生物衰老； （2）进行详细的神经心理学 评估WSTR队列中认知功能的评估，并将这些变量用作关键结果 联合型号。社会隔离和孤独可能会在认知功能中下降，但是这些是 与因果关系一致的关联？我们将对 2,000名WSTR参与者使用针对与认知结果相关的认知结果的评估 加速认知能力下降，轻度认知障碍以及阿尔茨海默氏病及相关的生物标志物 痴呆症； （3）检查日常社会功能的客观衡量与 WSTR中的健康和认知结果。电子激活的录音机（EAR）是 智能手机应用程序记录参与者日常生活中的环境声音，并提供 仅仅评估仅自我报告以外的社会行为。我们将从140个成人的子样本中收集耳朵数据 MZ双对与WSTR的婚姻状况不一致（n = 280），以确定是否在双对差异之内 在社会融合的客观指标中与健康，健康行为和认知有关 结果。成功完成拟议的研究将有助于为公共卫生建立因果基础 围绕社会关系的干预工作。