Infection and Immunity: The Pathogenesis of Host-Microbe Interactions

感染和免疫：宿主-微生物相互作用的发病机制

• 批准号: 10492947
• 负责人: Paul Dunman
• 金额: $ 26.4万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10492947
• 关键词: Immunity; Infection; Pathogenesis; host-microbe interactions

ABSTRACT The current SARS-CoV-2 pandemic has made it readily apparent that infectious diseases are a major threat to U.S. health. The goal of this predoctoral T32 program is to train the next generation of researchers in microbiology, and to prepare them with the skills necessary to address the nation’s critical needs in the battle against infectious disease. To do this, we have developed a training program that takes a student-centric, autonomy-supportive approach with the goal of training self-motivated, independent research scientists who are well prepared for diverse research careers. Innovative program features include: an autonomy-supportive educational approach that encourages self-directed exploration of diverse career options; instruction in the “soft skills” necessary for research career success; and the establishment of faculty mentoring practices that support student autonomy and self-directed learning. The program’s renewal expands and enhances our 6 overarching objectives. First, it will provide outstanding interdisciplinary research training in microbial pathogenesis, in part by leveraging unique opportunities created by signature institutional NIH-funded centers that include the Center of Excellence for Influenza Research and Surveillance, Environmental Health Science Center, Vaccine and Treatments Evaluation Unit, and the University of Rochester’s Clinical and Translational Sciences Institute. Second, it will provide outstanding education in microbiology and pathogenesis, which incorporates four major components: 1. a streamlined required core didactic curriculum; 2. required program-specific experiences (including courses, workshops and career/professional development activities); 3. optional elective courses and experiences designed to encourage student exploration, and 4. hands-on thesis research. Third, it will train self-directed, autonomous scientists who are prepared for diverse research career options. To facilitate this, all trainees will complete a personality inventory and an annual Individualized Development Plan (IDP), participate in “Microbiology Career Stories” and other activities offered by the UR’s Broadening Experiences in Scientific Training program which provides avenues for diverse career exploration, and offered the opportunity to participate in extramural internships. Fourth, we provide training in the “soft-skills” necessary for success through participation in a “Leadership Academy” program and supervised training in mentoring. Fifth, we will continue to improve faculty mentoring practices through required instruction in autonomy supportive mentoring practices involving IDPs and “Mentor our Mentors” workshops. Sixth, we will develop a new UR Student Lifecycle program to longitudinally track program alumni, obtain experiential feedback to further optimize the program, assess career outcomes, and establish a formal portal to facilitate trainee networking and career advancement.

抽象的 当前的 SARS-CoV-2 大流行已清楚地表明传染病是主要疾病 该博士前 T32 项目的目标是培训下一代研究人员 微生物学，并为他们提供必要的技能，以满足国家在战斗中的关键需求 为此，我们制定了一项以学生为中心的培训计划， 自主支持方法，目标是培养自我激励、独立研究的科学家 为多样化的研究职业做好了充分的准备，创新项目的特点包括：自主支持。 鼓励自主探索“软”职业选择的教育方法； 研究事业成功所必需的技能”，以及建立支持教师指导的做法； 学生的自主性和自主学习。 该计划的更新扩展并增强了我们的 6 个总体目标。 微生物发病机制方面杰出的跨学科研究培训，部分是通过利用独特的 由 NIH 资助的标志性机构中心创造的机会，其中包括卓越中心 流感研究和监测、环境健康科学中心、疫苗和治疗 其次，它将是评估单位和罗切斯特大学临床与转化科学研究所。 提供出色的微生物学和发病机制教育，其中包括四个主要组成部分：1。 精简所需的核心教学课程； 2. 所需的特定项目经验（包括课程、 3. 可选的选修课程和经历 旨在鼓励学生探索，以及4.实践论文研究第三，它将训练自我导向， 为多样化的研究职业选择做好准备的自主科学家为了促进这一点，所有学员都将这样做。 完成性格调查和年度个性化发展计划（IDP），参与 “微生物学职业故事”和 UR 扩大科学经验提供的其他活动 培训计划为多样化的职业探索提供了途径，并提供了机会 第四，我们通过参加校外实习提供成功所需的“软技能”培训。 第五，我们将继续参与“领导学院”计划和指导培训。 通过自主支持指导实践中的必要指导来改善教师指导实践 国内流离失所者和“指导我们的导师”研讨会第六，我们将制定一项新的涉及 UR 学生生命周期计划。 纵向跟踪项目校友，获取体验反馈进一步优化项目，评估 职业成果，并建立正式门户网站以促进学员交流和职业发展。