Molecular Regulation of B cells and T cells in Human SLE

人类 SLE 中 B 细胞和 T 细胞的分子调控

基本信息

批准号：
10493525
负责人：
Ignacio E. Sanz
金额：
$ 8.88万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10493525
关键词：
Antigens Antitumor Response Autoantigens Autoimmune Autoimmune Diseases Autoimmune Responses Autoimmunity B cell differentiation B-Cell Development B-Lymphocytes Biological Markers CD8-Positive T-Lymphocytes Cancer Patient Categories Cell physiology Cells Chronic Clinical Clinical Protocols Clinical Research Collaborations Committee Members Comparative Study Development Diagnosis Disease Effector Cell Epigenetic Process Evolution Funding Genetic Predisposition to Disease Goals Heterogeneity Human Immune Immune checkpoint inhibitor Immune response Immunologics Individual Knowledge Lead Leadership Location Lupus Maintenance Mission Molecular Onset of illness Outcome PD-1 blockade Pathogenesis Pathogenicity Pathway interactions Patients Physicians Pilot Projects Population Process Regulation Resources Scientist Systemic Lupus Erythematosus T-Lymphocyte Translating Universities Virus Diseases Work arm autoreactive B cell base clinical development design epigenetic regulation epigenome exhaustion experience immunogenic imprint innovation novel operation personalized medicine programs response self-renewal stem stem-like cell

项目摘要

Abstract The Emory ACE Fund Management Core (EAFMC) at Emory University proposes to manage on behalf of the ACE network two funds. The first will be the Clinical Project Fund, which will support all of the Clinical Projects (ClinProj) within the ACE. The second will be the Collaborative Research Fund (CRF). The CRF will provide funding support for the Collaborative Projects of the ACE, as well as additional studies that are added for achieving the ACE research agenda. It is estimated from the RFA that the AFMC will manage $3.2M in direct costs associated with these projects and that these will occur through about 100 consortium agreements emanating from up to 50 different sites. It will accomplish this through the following aims: (1) Establishing an effective administrative structure and operating unit, (2) developing plans to effectively produce and execute budgets and consortium agreements, (3) establish templates for the ClinProj and CRP budget agreements, (4) develop procedures to pay invoices and resolve problems; and (5) develop procedures for accountability, communication, and reporting to the ACE Steering committee and NIAID.

抽象的埃默里大学的埃默里 ACE 基金管理核心 (EAFMC) 建议管理代表ACE网络两只基金。第一个是临床项目基金，它将支持 ACE 内的所有临床项目 (ClinProj)。第二个将是协作研究基金（CRF）。 CRF将为CRF的合作项目提供资金支持 ACE，以及为实现 ACE 研究议程而添加的其他研究。这是 RFA 估计 AFMC 将管理与这些相关的直接成本 320 万美元这些项目将通过来自 up 的约 100 项联合体协议来实现到 50 个不同的站点。它将通过以下目标来实现这一目标：（1）建立有效的行政结构和经营单位，（2）制定计划以有效生产和执行预算和联合体协议，(3) 建立 ClinProj 和 CRP 模板预算协议，（4）制定支付发票的程序并解决问题；和（5）制定问责、沟通和向 ACE 指导报告的程序委员会和 NIAID。