Cellular and Molecular Oncology

细胞和分子肿瘤学

基本信息

批准号：
10491116
负责人：
Michelle A Ozbun
金额：
$ 11.94万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-26 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10491116
关键词：
Address Affect American Indians Animal Model Area Arsenic Automobile Driving Autophagocytosis Basic Science Behavior Behavioral Biochemical Biochemical Pathway Biochemical Process Bioinformatics Biology Biometry Cancer Center Support Grant Cancer Control Cancer Etiology Catchment Area Cell Communication Cell Culture System Cell model Cell physiology Cells Centers of Research Excellence Clinic Clinical Clinical Cancer Center Collaborations Communities Comprehensive Cancer Center Computer Models Development Direct Costs Doctor of Philosophy Environmental Carcinogens Environmental Exposure Environmental Pollution Epigenetic Process Exposure to Extramural Activities Flow Cytometry Funding Genetic Genetic study Genome Genome Stability Genomic approach Genomics Goals Grant Growth Human Imaging technology Immunology Incidence Indigenous American Inflammation Intervention Laboratories Malignant Neoplasms Mentors Metabolism Microscopy Modernization Molecular Molecular and Cellular Biology Mutation NCI Center for Cancer Research New Mexico Normal Cell Nuclear Pathway interactions Peer Review Pharmacy facility Phenotype Population Population Research Population Sciences Process Prognostic Marker Publications RNA Regulation Research Research Institute Research Personnel Resolution Resource Sharing Risk Factors Sampling Science Signal Pathway Signal Transduction Technology Therapeutic Therapeutic Human Experimentation Tissue imaging Tissues Tobacco use Training Training Programs Transcriptional Regulation Translating Translational Research Translations Ultraviolet Rays United States National Institutes of Health Universities Uranium Virus anticancer research cancer cell cancer genome cancer health disparity cancer initiation carcinogenesis carcinogenicity cellular imaging cellular oncology clinical translation college community setting diagnostic biomarker digital pathology environment related cancer fundamental research genome sequencing genome-wide high-throughput drug screening hispanic community imaging platform innovation interdisciplinary approach medical schools member microscopic imaging molecular oncology mortality novel oncology program patient engagement predictive modeling programs respiratory spatiotemporal synergism tumor initiation tumor microenvironment tumor progression working group

项目摘要

ABSTRACT: The Cellular and Molecular Oncology Research Program (CMO) is the fulcrum of basic mechanistic science in the University of New Mexico Comprehensive Cancer Center (UNMCCC). It facilitates inter-programmatic collaboration and translation to population research in the Cancer Control & Population Science Research (CCPS) Program and clinical-translational research in the Cancer Therapeutics Research (CT) Program to address cancers that are prevalent in New Mexico’s catchment area and the nation. Our overarching goals are to conduct outstanding cancer-relevant research in order to discover the cellular and molecular mechanisms that govern tumor initiation and drive cancer progression. These goals are accomplished through thematic research encompassing three scientific aims: (1) Carcinogenic Mechanisms of Environmental Exposures: To discover the molecular and cellular mechanisms by which environmental carcinogens and behavioral risk factors relevant to our catchment area promote cancer; (2) Genome Regulation: To define the mechanisms and pathways by which genome stability, epigenetic alterations, and transcriptional regulation are disrupted in cancer cells; and (3) Cellular Signaling and the Tumor Microenvironment: To determine how cell signaling pathways, cellular activities, and cell-cell interactions are altered during cancer initiation and progression and within the tumor microenvironment. The Program is led by Steven Belinsky, PhD, Mary Ann Osley, PhD, and Michelle Ozbun, PhD (incoming program co-leader as of 2020), who bring complementary expertise in the areas of molecular and cellular biology. The 37 Full Members and 4 Associate Members are drawn from 6 Basic Science and 4 Clinical Departments and Divisions in the UNM School of Medicine, and the UNM College of Pharmacy. The Program also takes advantage of the expertise of investigators in 2 UNM main campus departments, the Lovelace Respiratory Research Institute (LRRI) and Los Alamos National Laboratory, as well as state-of-the-art technologies provided by CCSG-supported Shared Resources. Annual direct cost funding as of 9/1/2020 equaled $8.7M ($2M from the NCI and $8M peer-reviewed). The discoveries made in this Program resulted in 352 publications, of which 38% were intra-programmatic collaborations and 26% were inter-programmatic collaborations, with a total collaborative publication level of 53%. Going forward, CMO will promote the growth of our new Program through expansion of program expertise and enhancement of program collaborations. CMO will continue to grow its expertise in discovery of the basic cellular and molecular mechanisms driving cancer, and build on its unique technological capabilities in advanced cell and tissue imaging, computer modeling, and state-of-the-art genomics to drive fundamental research in cancer etiology and progression and translate results to the clinic, our population and beyond.

摘要：细胞和分子肿瘤学研究计划（CMO）是基础研究的支点。新墨西哥大学综合癌症中心 (UNMCCC) 的机械科学。癌症控制与人口领域的项目间合作和人口研究转化癌症治疗研究中的科学研究 (CCPS) 计划和临床转化研究 (CT) 解决新墨西哥州流域和全国流行癌症的计划。总体目标是进行出色的癌症相关研究，以发现细胞和控制肿瘤发生和驱动癌症进展的分子机制已经实现。通过涵盖三个科学目标的专题研究：（1）环境致癌机制暴露：发现环境致癌物和致癌物的分子和细胞机制与我们的学区相关的行为风险因素会促进癌症；(2) 基因组调控：定义基因组稳定性、表观遗传改变和转录调控的机制和途径 (3) 细胞信号转导和肿瘤微环境：确定细胞如何被破坏信号通路、细胞活动和细胞间相互作用发生在癌症发生和发展过程中该项目由 Steven Belinsky 博士和 Mary Ann 领导。 Osley 博士和 Michelle Ozbun 博士（2020 年即将上任的项目联合负责人），他们带来了互补 37 名正式会员和 4 名准会员是分子和细胞生物学领域的专业知识。来自新墨西哥大学医学院的 6 个基础科学系和 4 个临床系和部门，以及新墨西哥州药学院该计划还利用了新墨西哥州 2 个主要研究人员的专业知识。校园部门、洛夫莱斯呼吸研究所 (LRRI) 和洛斯阿拉莫斯国家实验室，以及 CCSG 支持的共享资源提供的最先进的技术。截至 2020 年 9 月 1 日，资助金额为 870 万美元（200 万美元来自 NCI，800 万美元经过同行评审）。该计划产生了 352 份出版物，其中 38% 是计划内合作，26% 是跨项目合作，合作出版总量将达到 53%。通过扩展项目专业知识和增强项目来促进我们新项目的发展 CMO 将继续增强其在基础细胞和分子发现方面的专业知识。驱动癌症的机制，并以其在先进细胞和组织方面的独特技术能力为基础成像、计算机建模和最先进的基因组学，以推动癌症病因学和进展并将结果转化为诊所、我们的人群及其他领域。