Mentored Patient Oriented Research in ARDS and Critical Illness Outcomes

指导 ARDS 和危重疾病结果中以患者为导向的研究

• 批准号: 10491660
• 负责人: Catherine Lee Hough
• 金额: $ 11.86万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491660
• 关键词: Acute; Acute Respiratory Distress Syndrome; Admission activity; Affect; Area; Award; Biology; Cessation of life; Chest; Chronic; Clinical; Clinical Data; Clinical Trials; Communities; Conduct Clinical Trials; Critical Care; Critical Illness; Data; Development; Development Plans; Disease; Distress; Educational workshop; Electrophysiology (science); Enrollment; Environment; Epidemiologic Methods; Etiology; Faculty; Family; Funding; Future; Goals; Health; Health Services Research; Health Status; Hospital Mortality; Image; Impairment; Infrastructure; Injury; Intervention; Intervention Studies; Knowledge; Leadership; Learning; Lung; Measures; Mechanical ventilation; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Morbidity - disease rate; Muscle; Muscle function; National Center for Complementary and Integrative Health; National Heart, Lung, and Blood Institute; Observational Study; Online Systems; Outcome; Outcome Study; Patient Education; Patient-Focused Outcomes; Patients; Personal Satisfaction; Persons; Phenotype; Physical Function; Play; Postdoctoral Fellow; Principal Investigator; Prospective cohort; Proxy; Recovery; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Scanning; Science; Scientist; Sleep; Structure; Survivors; Techniques; Time; Training; Universities; Washington; Work; X-Ray Computed Tomography; abdominal CT; career; career development; clinical care; clinical epidemiology; clinical practice; cohort; comorbidity; design; disability; disability burden; functional disability; health care service utilization; health related quality of life; improved; improved outcome; innovation; mentoring community; mindfulness intervention; mortality; muscle form; muscle strength; neuromuscular; novel; outcome prediction; patient oriented; patient oriented research; programs; prospective; randomized trial; reduced muscle mass; research and development; risk stratification; sarcopenia; skills; student mentoring; success; successful intervention

PROJECT SUMMARY/ABSTRACT The goal of this Midcareer Investigator Award in Patient Oriented Research is to provide key mentorship, resources and protected time to strengthen Dr. Catherine Hough's success in mentoring students, post- doctoral fellows and junior faculty in the science of patient-centered outcomes after the acute illness and injury, with a focus on the acute respiratory distress syndrome and critical illness. Although hospital mortality after critical illness has improved significantly over the past decades, there is increasing recognition that recovery is incomplete, with a substantial burden of disability and impairments in function and health-related quality of life among ICU survivors. Interventions to improve these patient-centered outcomes have been largely unsuccessful, and understanding of the mechanisms of post-ICU impairments remains quite limited. Recently, there has been increased recognition that pre-morbid health and disability are significant contributors to post- ICU impairment and to the heterogeneous trajectories of recovery, but research and clinical practice have been stalled by the difficulty of assessing pre-morbid factors at the time of ICU admission. Moving the field forward will require innovative approaches to phenotyping patients using clinical data and techniques from clinical epidemiology and health services research. Dr. Hough is an ideal candidate to provide mentorship in this area. She is a mid-career investigator with expertise in observational and interventional studies of outcomes after ARDS and critical illness, and she has a strong and growing track record in successful mentorship in patient- oriented research as well as a strong existing research program. In this award, Dr. Hough will enhance and advance her career in three ways. She will participate in structured activities to develop her mentoring skills, including one-on-one sessions with Dr. Randy Curtis, local in-person workshops and national web-based programs. She will gain content knowledge on muscle biology, use of computed tomography images in assessing muscle mass and quality. Additionally, she will work with methods experts to learn to incorporate clinical and administrative data of co-morbidity and health-care utilization into developing phenotypes of premorbid disease that predict disability and recovery. The scientific goal of this project is to investigate the relationship between premorbid muscle mass and quality, assessed via analysis of existing computed tomography scans, and short and long-term outcomes after critical illness, including muscle strength, function and disability. This project will leverage two ongoing R01-funded prospective cohorts for which Dr. Hough is a PI which contain detailed assessment of co-morbidities and pre-morbid health care utilization, prospective assessments of muscle strength and function during and after critical illness, and will create new opportunities for mentored research. Dr. Hough's career development and scientific aims will provide an outstanding environment for training of patient-oriented researchers focused on improving outcomes after critical illness.

项目摘要/摘要 这项中级护理研究员奖的目标是以患者为导向的研究提供关键指导， 资源和受保护的时间加强凯瑟琳·霍夫博士在指导学生方面的成功，之后 急性疾病和受伤后，以患者为中心的结果科学的博士研究员和初级教师 重点是急性呼吸窘迫综合征和重症疾病。虽然在此之后的医院死亡率 在过去的几十年中，危重疾病有了显着改善，人们越来越认识到康复是 不完整，在功能和与健康相关的生活质量方面承担着很大的残疾和障碍负担 在ICU幸存者中。改善这些以患者为中心的结果的干预措施在很大程度上是 不成功，对ICU后损伤机制的理解仍然非常有限。最近， 人们越来越认识到，治疗前的健康和残疾是后期的重要贡献者 ICU损害和恢复的异质轨迹，但是研究和临床实践一直是 ICU入院时很难评估过期因素的困难。向前移动领域 将需要使用临床临床数据和技术来对患者进行创新方法 流行病学和卫生服务研究。霍夫博士是在这一领域提供指导的理想候选人。 她是一名职业中期研究者 ARDS和重症疾病，她在成功的指导方面拥有强劲而增长的记录 - 定向研究以及强大的现有研究计划。在这个奖项中，霍夫博士将增强和 以三种方式发展她的职业生涯。她将参加结构化的活动，以发展她的指导能力， 包括与兰迪·柯蒂斯（Randy Curtis）博士，本地面对面研讨会和国家网络的一对一会议 程序。她将获得有关肌肉生物学的内容知识，在 评估肌肉质量和质量。此外，她将与方法专家合作学习合并 合并症和医疗保健利用的临床和行政数据 预测残疾和康复的病前疾病。该项目的科学目标是调查 病前肌肉质量与质量之间的关系，通过对现有计算的分析进行评估 层析成像扫描以及重症疾病后的短期和长期结局，包括肌肉力量，功能 和残疾。该项目将利用两个正在进行的R01资助的潜在队列，Hough博士是 PI包含详细评估合并症和疗程前医疗保健利用的PI 评估疾病期间和之后的肌肉力量和功能，并将创造新的机会 进行指导的研究。霍夫博士的职业发展和科学目标将提供出色的 培训以患者为导向的研究人员的环境致力于改善危重疾病后的结局。