Michigan Interdisciplinary Center for Urology Research and Education (MI-CURE)

密歇根泌尿外科研究和教育跨学科中心 (MI-CURE)

• 批准号: 10491200
• 负责人: MICHAEL B CHANCELLOR
• 金额: $ 29.41万
• 依托单位: WILLIAM BEAUMONT HOSPITAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491200
• 关键词: Address; Adult; Applications Grants; Area; Benign; Biological; Biomechanics; Bladder; Bladder Dysfunction; Cellular biology; Clinical; Collaborations; Communication; Development; Discipline; Disease; Education; Engineering; Ensure; Environment; Esthesia; Event; Fibrosis; Fostering; Foundations; Functional disorder; Funding; Future; Genitourinary system; Goals; Health system; High School Student; Hospitals; Image; Infrastructure; Interdisciplinary Study; Investigation; Joints; K-Series Research Career Programs; Knowledge; Mechanics; Medical Students; Mentors; Methodology; Michigan; Movement; Muscle; Muscle Tonus; Physicians; Physiology; Positioning Attribute; Prevention strategy; Program Development; Property; Research; Research Personnel; Resources; Role; Scientist; Sensory; Site; Stress; Stretching; Sum; System; Talents; Testing; Training; United States National Institutes of Health; Universities; Urogenital Diseases; Urologist; Urology; Work; afferent nerve; base; career; career development; conflict resolution; design; high school; imaging system; innovation; insight; interdisciplinary collaboration; interest; mathematical model; medical schools; meetings; novel; novel therapeutics; pressure; programs; recruit; sex; soft tissue; statistics; success; symposium; synergism; training opportunity; treatment strategy; urologic

ABSTRACT The Michigan Interdisciplinary Center for Urology Research and Education (MI-CURE) seeks to develop a world-class interdisciplinary research team comprised of scientists, clinicians, biostatisticians, and engineers to provide comprehensive and innovative approaches in benign urology. As such, we have brought together exceptional investigators with diverse expertise from Beaumont Hospital/ Oakland University William Beaumont School of Medicine and Michigan State University. The overall purpose of the MI-CURE Exploratory Center is to establish strong research foundations in bladder physiology, develop an intellectual infrastructure, and expand educational and training opportunities in benign urology research. Despite decades of research, the mechanisms by which bladder fullness is sensed are still unknown. A major barrier to developing and testing novel therapies for bladder dysfunction is our lack of understanding the mechanism of how bladder fullness is sensed. Thus, the overall goal of this initial project is to understand the basis of pressure sensing and its linkage to afferent nerve activation during bladder filling, and consequently how bladder remodeling and altered bladder wall compliance during disease can impact these mechanisms. To address this significant knowledge gap, we have assembled an interdisciplinary team of experts in physiology, cell biology, fibrosis, neurourology, statistics, and clinical urology and have recruited a promising new investigator in engineering to benign genitourinary disease, Dr. Sara Roccabianca. She has unique expertise in soft tissue mechanical characterization, microstructural quantification, and mathematical modeling of soft tissues movement. In addition to the strong benign urology research program using innovative and cutting-edge approaches, MI-CURE has an exciting Educational Enrichment Program to train and mentor all levels of adult learners, from high school students to medical students, to help expand and enhance benign urology research. MI-CURE is co-directed by the established physician-scientist team of Drs. Laura Lamb and Michael Chancellor, with clear communication and coordination plans in place. Together, MI-CURE will foster successful collaborations, education initiatives, and innovative research. Funding of MI-CURE as a P20 Exploratory Center will allow us to work with the George M. O'Brien Urology Cooperative Research Centers Program and the KURe and UroEpi career development programs through joint meetings and conference calls. Our goal is to leverage our collective resources and results into well-designed, novel projects suitable for submission as future NIH Investigator-Initiated R01s. We believe that the Michigan Interdisciplinary Center for Urology Research and Education program as a whole will be greater than the sum of its parts and will contribute to developing talented researchers in benign genitourinary disorders.

抽象的 密歇根州泌尿外科研究与教育跨学科中心（MI-CURE）寻求 建立一个由科学家，临床医生，生物统计学家组成的世界一流的跨学科研究团队， 和工程师提供良性泌尿科的全面和创新方法。因此，我们有 从Beaumont医院/奥克兰汇集了具有多种专业知识的杰出调查员 威廉·博蒙特医学院和密歇根州立大学。 Mi-Cure探索中心的总体目的是建立强大的研究基础 在膀胱生理学中，开发智力基础设施，扩大教育和培训 良性泌尿科研究的机会。尽管进行了数十年的研究，但膀胱的机制 感觉饱满仍然未知。开发和测试膀胱新颖疗法的主要障碍 功能障碍是我们缺乏了解膀胱饱满感的机制。因此，整体 这个最初项目的目标是了解压力感应及其与传入神经的联系的基础 膀胱填充过程中的激活，因此膀胱重塑和膀胱壁的变化如何 疾病期间的依从性会影响这些机制。为了解决这一重要的知识差距，我们 已经组建了一个跨学科的生理学专家团队，细胞生物学，纤维化，神经病学， 统计和临床泌尿外科，并招募了一位有前途的新研究者，以良性 泌尿生殖病，Sara Roccabianca博士。她在软组织机械方面具有独特的专业知识 软组织运动的表征，微结构定量和数学模型。 除了使用创新和尖端的强大良性泌尿科研究计划 方法，Mi-Cure具有令人兴奋的教育丰富计划，以培训和指导各个级别 从高中生到医学生的成人学习者，以帮助扩展和增强良性泌尿外科 研究。 Mi-Cure由既定的医师科学家DRS团队共同指导。劳拉·兰姆（Laura Lamb）和 迈克尔·总理（Michael Chancellor），制定了明确的沟通和协调计划。在一起，Mi-Cure会 促进成功的合作，教育计划和创新研究。 Mi-Cure作为P20探索中心的资金将使我们能够与George M. O'Brien合作 泌尿外科合作研究中心计划以及Kure和Uroepi职业发展计划 通过联合会议和电话会议。我们的目标是利用我们的集体资源和结果 专门设计的新型项目适合提交为未来的NIH研究者发起的R01。我们 相信密歇根州泌尿外科研究和教育计划的整体 将大于其部分的总和，并将为发展良性的有才华的研究人员做出贡献 泌尿疾病。