Characterizing individual differences in the reciprocal relationship between sleep deprivation and binge drinking within the context of college life

描述大学生活背景下睡眠不足和酗酒之间相互关系的个体差异

• 批准号: 10491671
• 负责人: Jennifer F. Buckman
• 金额: $ 43.49万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-25 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10491671
• 关键词: Acute; Affect; Alcohol consumption; Alcohol withdrawal syndrome; Alcohols; Behavior; Behavioral; Biological Markers; Blood Circulation; Cardiovascular Physiology; Cardiovascular system; Chronic; Consumption; Data; Development; Disease; Ensure; Environment; Event; Grain; Habits; Health; Home; Inadequate Sleep Hygiene; Individual; Individual Differences; Intoxication; Life; Link; Longitudinal Studies; Maps; Measurable; Measures; Mental Health; Mental disorders; Parents; Participant; Patient Self-Report; Pattern; Persons; Physiological; Physiology; Play; Polysomnography; Procedures; Protocols documentation; Public Health; REM Sleep; Recovery; Relapse; Reporting; Research; Risk; Risk Factors; Role; Saliva; Sleep; Sleep Architecture; Sleep Deprivation; Sleep disturbances; Slow-Wave Sleep; Stress; Test Result; Testing; Time; actigraphy; addiction; alcohol consequences; alcohol effect; alcohol misuse; alcohol research; alcohol response; alcohol risk; alcohol testing; alcohol use disorder; behavior influence; binge drinking; college; design; diaries; drinking; improved; indexing; individual variation; innovation; maladaptive behavior; physical conditioning; poor sleep; psychologic; rapid eye movement; recruit; response; secondary analysis; sleep behavior; sleep pattern; sleep physiology; sleep quality; sleep quantity; stem; university student; wearable device; young adult

Abstract There is strong evidence that maladaptive behaviors, including poor sleep hygiene and binge drinking, emerge in the college environment. When repeated in cycles, risk of habit development increases. This may contribute to the development of addiction, psychiatric illness, and physical disease. Both chronic sleep deprivation and frequent excessive alcohol use disrupt behavioral and physiological functioning, and their relationship appears reciprocal. Research on individual differences in the alcohol-sleep relationship is largely unexplored, but may identify putative biomarkers for immediate and long-term risks of alcohol misuse. This proposal's public health significance stems from its potential to reduce immediate alcohol-related harms in college students and develop scientific premise for improving the lives of individuals with sleep and alcohol use disorders. Proposed studies build from an ongoing longitudinal study of college students (R01 AA027017), using its participants, weekly drinking data, and physiological protocols. It maps the sleep-alcohol relationship onto individual drinking bouts. It pairs self-reported sleep quality with objective measures of sleep behavior (actigraphy) and physiology (polysomnography) that are collected before, during, and after a drinking bout. Sleep is operationalized as a multidimensional and dynamic behavior that is measurable within and across discrete episodes. Self-reported alcohol use and consequences are paired with a cardiovascular reactivity test that objectively assesses proximal physiological repercussions of drinking. Study 1 (n= 150) is a one-week actigraphy study of sleep duration, timing, and fragmentation. Aim 1 focuses on sleep behaviors preceding a drinking event (i.e., pre-intoxication) and assesses how cumulative sleep debt and sleep irregularity influence individual differences in the immediate consequences of drinking measured from self-report and cardiovascular reactivity. Aim 2 targets sleep on the night of a drinking event (i.e., during intoxication) and assesses individual differences in acute alcohol effects on sleep quantity and quality, as well as associations with alcohol use behaviors across the subsequent week and over 2-years. Study 2 (n=25) involves at-home, overnight polysomnography sessions on a night following a drinking night and on a night that does not follow drinking to assess sleep architecture (e.g., time spent in rapid eye movement (REM) and slow-wave sleep) changes. Aim 3 explores how sleep is altered during recovery (i.e., post-intoxication) from drinking and if individual differences in sleep physiology relate to sleep behavior and cardiovascular physiology. This application innovates through its use of multi-level assessments of sleep and alcohol use; concurrently collecting objective data may help dissociate contextual influences on self-report. It also innovates with a multi-PI design that ensures primary expertise in both the alcohol and sleep fields. Added value for the proposed studies comes from the resulting intensive, day-level, longitudinal data that has the potential to generate secondary analyses focused on event-level data of within-subject alcohol-sleep relationships across time.

抽象的 有充分的证据表明，适应不良的行为，包括睡眠不良和暴饮暴食，出现了 在大学环境中。当在周期中重复时，习惯发展的风险会增加。这可能会贡献 成瘾，精神病和身体疾病的发展。两者都是慢性睡眠剥夺和 频繁过度的酒精使用破坏行为和生理功能，并且它们的关系出现 互惠的。关于酒精睡眠关系中个体差异的研究在很大程度上没有探索，但可以 确定假定的生物标志物，以立即滥用酒精的风险。该提议的公共卫生 意义源于其减少大学生与酒精有关的危害的潜力和 发展科学前提来改善患有睡眠和饮酒障碍的人的生活。建议的 研究是根据正在进行的大学生的纵向研究（R01 AA027017）的研究，使用其参与者， 每周饮酒数据和生理方案。它将睡眠 - 酒精关系映射到个人 喝酒。它将自我报告的睡眠质量与客观的睡眠行为（Actraphy）和 在喝酒之前，期间和之后收集的生理学（多摄影术）。睡眠是 作为多维和动态行为，可在离散内和跨离散范围内进行操作 情节。自我报告的酒精使用和后果与心血管反应性测试配对 客观地评估饮酒的近端生理影响。研究1（n = 150）是一周 睡眠持续时间，时机和碎片化的行为研究。 AIM 1专注于之前的睡眠行为 饮酒事件（即促毒事），并评估累积睡眠债务和睡眠不规则的影响 通过自我报告和心血管衡量的饮酒的直接后果的个体差异 反应性。 AIM 2目标在饮酒事件的夜晚（即在中毒期间）睡觉并评估个人 急性酒精对睡眠数量和质量的影响以及与酒精使用的关联 随后一周和2年以上的行为。研究2（n = 25）涉及在家，一夜之间 饮酒之夜和不跟随饮酒的夜晚的一个晚上，多聚会学会议 评估睡眠体系结构（例如，在快速眼动（REM）和慢波睡眠中花费的时间变化。目的 3探讨在康复过程中的睡眠如何改变（即，在饮酒后）以及是否个体 睡眠生理的差异与睡眠行为和心血管生理有关。此应用程序 通过使用多层次的睡眠和饮酒评估来创新；同时收集目标 数据可能有助于分离上下文对自我报告的影响。它还以多PI设计进行创新 确保酒精和睡眠场上的主要专业知识。拟议研究的附加值是 从由此产生的密集，日级，纵向数据，具有产生次级分析的潜力 专注于跨时间的受试者内酒精性关系的事件级数据。