Biopsychosocial Mechanisms in the Development and Progression of Periodontal Disease

牙周病发生和进展的生物心理社会机制

• 批准号: 10489819
• 负责人: Casey D Wright
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10489819
• 关键词: Adult; Affect; Age; Attitude; Award; Bacteria; Behavioral; Biological; Biological Factors; Biological Models; Clinical; Complex; Data; Dental; Dental Care; Dentistry; Development; Diagnostic; Diet; Disease; Environment; Enzyme-Linked Immunosorbent Assay; Etiology; Focal Infection; Frequencies; Future; Genetic Predisposition to Disease; Gingiva; Gingival Crevicular Fluid; Goals; Gram-Negative Bacteria; Health; Health behavior; Healthcare; Human; Immune response; Immunology; Individual; Inflammatory; Inflammatory Response; Interleukin-6; Intervention; Lead; Life; Maintenance; Measures; Mediating; Mentors; Mentorship; Modeling; Mouth Diseases; Mucous Membrane; Nature; Onset of illness; Oral; Oral health; Participant; Pathway Analysis; Patient Self-Report; Patients; Periodontal Diseases; Periodontic specialty; Periodontium; Permeability; Personal Satisfaction; Persons; Phase; Physiological; Population; Population Distributions; Porphyromonas gingivalis; Postdoctoral Fellow; Process; Proteins; Psychological Factors; Psychological Stress; Psychology; Quality of life; Reporting; Research; Research Training; Risk Behaviors; Risk Factors; Role; Salivary; Science; Scientist; Serum; Smoking; Social Behavior; Social Environment; Social Network; Socioeconomic Factors; Socioeconomic Status; Stress; Symptoms; System; Time; Tissues; Training; Translating; Underserved Population; Work; base; biopsychosocial; biopsychosocial factor; career; craniofacial; cytokine; disorder prevention; disorder risk; experience; improved; multidisciplinary; novel; novel marker; person centered; pre-doctoral; psychobiologic; psychologic; psychosocial; response; scaling and root planing; social; social culture; social epidemiology; socioeconomics; zonulin

PROJECT SUMMARY In recognition of the importance of treating whole persons, biopsychosocial approaches have long been championed. The emphasis in health and disease research, however, is in biological abnormalities. Examining diseases from psychological and socio-behavioral perspectives adds unique perspectives in understanding the etiology and course of any given disease. That is, greater understanding is needed in elucidating how and why biopsychosocial factors may precipitate the onset of disease. Periodontal disease continues to be among the most prevalent dental, oral, and craniofacial conditions across the globe. Patients with periodontal disease— especially those from underserved populations—are faced with potentially life-long symptoms that affect their overall health and quality of life. Additional work is needed to characterize the mechanisms that explain biopsychosocial relations contributing to periodontal disease. Thus, work that tackles the multidisciplinary and complex systems nature of periodontal disease is needed to help facilitate future preventative, mitigating, and restorative interventions based on biological, psychological, and socioeconomic mechanisms. During the F99 phase of this proposal, the awardee will continue through dissertation work, to examine a novel psycho- biological mechanism by exploring the role of the protein zonulin (modulator of tissue permeability) in periodontal parameters and its potential ability to explain the relation between psychological stress and periodontal disease. More specifically, the awardee will examine the relation of zonulin, as measured by serum, salivary, and gingival crevicular fluid ELISA, and periodontal disease parameters. Additionally, zonulin will be examined as a potential mediating and moderating factor in the relation between psychological stress and cytokines in periodontal examination participants. It is hypothesized that serum zonulin levels will mediate the relation between reports of psychological stress and various periodontal and inflammatory parameters (e.g., probing depth, attachment loss, IL-6 levels). In the K00 phase, the awardee will work in understanding the upstream socioeconomic (e.g., social networks) and psychological aspects (e.g., stress) of a biopsychosocial approach to understanding periodontal disease. It is hypothesized that people who report social connections with those they perceive to have poor oral health, who engage in risk behaviors (e.g. smoking, sugary diet), and who utilize dental care infrequently, will be more likely to report indicators of periodontal disease. Secondly, it is expected that poor psychological functioning will diminish social network effects. The F99 and K00 phases will utilize the training and mentorship gained as a predoctoral trainee and continuing to surround himself with mentors and in a multidisciplinary environment in his transition to the postdoctoral and early career stages of becoming an independent scholar. Thus, this award will facilitate the ability to identify novel biopsychosocial mechanisms in the development and progression of a complex oral disease through both its research and training plans.

项目摘要 认识到对待整个人的重要性，长期以来，生物心理社会方法一直是 拥护。但是，健康和疾病研究的重点是生物学异常。检查 从心理和社会行为的观点来看，疾病为理解 病因和任何给定疾病的病程。也就是说，在阐明如何以及原因时需要更大的理解 生物心理社会因素可能导致疾病的发作。牙周疾病仍在 全球最普遍的牙齿，口服和颅面状况。患有牙周疾病的患者 尤其是服务不足人群的人 - 面对潜在的终生症状 整体健康和生活质量。需要其他工作来表征解释的机制 生物心理社会关系导致牙周疾病。那是解决多学科和的工作 需要牙周疾病的复杂系统性质，以帮助促进未来的预防，缓解和 基于生物学，心理和社会经济机制的恢复性干预措施。在F99期间 该提案的阶段，获奖者将通过论文工作继续进行，以研究一种新颖的心理 生物学机制通过探索蛋白质齐原蛋白（组织渗透率调节剂）的作用 牙周参数及其解释心理压力之间关系的潜在能力与 牙周疾病。更具体地说，获奖者将检查扎洛蛋白的关系，如 血清，唾液和牙龈裂缝液ELISA以及牙周疾病参数。另外，Zonulin 将被视为心理压力之间关系中潜在的中介和调节因素 和牙周检查参与者中的细胞因子。假设血清齐原蛋白水平会介导 心理压力的报告与各种牙周和炎症参数之间的关系 （例如，探测深度，依恋损失，IL-6水平）。在K00阶段，获奖者将致力于理解 上游社会经济（例如社交网络）和心理方面（例如，压力） 理解牙周疾病的生物心理社会方法。假设报告的人 与他们认为口腔健康状况不佳的人的社会联系，从事风险行为（例如 吸烟，含糖饮食）以及很少使用牙齿护理的人更有可能报告指标 牙周疾病。其次，预计不良的心理功能会减少社交网络 效果。 F99和K00阶段将利用获得培训和精神训练，作为培训前学员， 在过渡到跨学科的环境中，继续与自己一起过渡到 成为独立学者的博士后和早期职业阶段。那是这个奖项将有助于 能够在复杂口腔的发展和发展中识别新型的生物心理社会机制 通过其研究和培训计划疾病。

项目成果

Food insecurity and consumption of cariogenic foods in mothers and their two-year-old children in Appalachia.

阿巴拉契亚地区母亲及其两岁儿童的粮食不安全和致龋食品的消费。

• DOI: 10.1111/jphd.12559
• 发表时间: 2023
• 期刊: Journal of public health dentistry
• 影响因子: 2.3
• 作者: Bhaumik,Deesha;Wright,CaseyD;Marshall,TeresaA;Neiswanger,Katherine;McNeil,DanielW;Jones,AndrewD;Shaffer,JohnR;Marazita,MaryL;Foxman,Betsy
• 通讯作者: Foxman,Betsy

Gastrointestinal distress as a potential mediator between stress and periodontal inflammation.

胃肠道不适是压力和牙周炎症之间的潜在中介。

• DOI: 10.1111/cdoe.12889
• 发表时间: 2023
• 期刊: Community dentistry and oral epidemiology
• 影响因子: 2.3
• 作者: Wright,CaseyD;Heaton,Brenda;Garcia,RaulI;Leonard,MaureenM;Fasano,Alessio;McNeil,DanielW
• 通讯作者: McNeil,DanielW