UMN Udall Imaging Core

UMN Udall 成像核心

• 批准号: 10489822
• 负责人: NOAM HAREL
• 金额: $ 34.2万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10489822
• 关键词: Algorithms; Anatomic Models; Anatomy; Axon; Basal Ganglia; Basic Science; Brain; Caliber; Clinical; Collaborations; Complement; Data; Databases; Deep Brain Stimulation; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Doctor of Philosophy; Electrodes; Foundations; Functional Magnetic Resonance Imaging; Generations; Globus Pallidus; Goals; Guidelines; Head; Human; Image; Implant; Individual; International; Lead; Location; MPTP model; MPTP non-human primate; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Methods; Minnesota; Modeling; Motor; National Institute of Neurological Disorders and Stroke; Neural Pathways; Neurosurgical Procedures; Operative Surgical Procedures; Outcome; Parkinson Disease; Pathway interactions; Patients; Predisposition; Prefrontal Cortex; Recommendation; Research; Resolution; Rest; Scanning; Site; Space Perception; Structure; Structure of subthalamic nucleus; System; Techniques; Training; Universities; Visualization; Work; X-Ray Computed Tomography; automated segmentation; base; catalyst; cognitive function; deep learning algorithm; denoising; image processing; imaging capabilities; implantation; in vivo; insight; neuroimaging; nonhuman primate; novel; patient subsets; predictive modeling; side effect; tool; tractography; ultra high resolution; white matter

ABSTRACT The University of Minnesota (UMN) Udall Imaging Core, led by Noam Harel, Ph.D. and based at the University of Minnesota’s internationally renowned Center for Magnetic Resonance Research (CMRR), will acquire state- of-the-art, high-resolution MRI for all subjects in the Projects and Catalyst. The overall theme of the UMN Udall Center is to develop novel, circuit based deep brain stimulation (DBS) therapies for Parkinson’s disease (PD). As a foundation for all three proposed projects, the Catalyst project and in collaboration with the other cores in support of this theme, the overall goal of the Imaging Core is to use advanced imaging capabilities for direct visualization of anatomical targets for DBS surgery as well as provide the precise location and orientation of individual stimulating electrode contacts within the target post-implantation. The Imaging Core will combine several cutting-edge MRI techniques, including high resolution T1/T2s and susceptibility weighted images (SWI). Diffusion weighted imaging (DWI) will also be acquired for white-matter tractography to create patient-specific anatomical models of the target region and associated networks. To complement the static anatomical connectivity information, we will create functional connectivity maps using resting-state and task based functional MRI (fMRI) data of circuit-based cognitive function/non-motor regions. For Projects 1, 2 and the Catalyst, PD patients will be scanned on a 7 T MRI system using tools developed by our team at the CMRR. In addition, in a subset of PD patients that will be implanted with the Medtronic Percept system, functional maps of DBS-fMRI stimulation will be collected on a 3T MRI system. For Project 3, non-human primates (NHPs) will be scanned on the newly installed, first of its kind, 10.5 T MRI scanner, also at the CMRR. For each PD patient and each NHP, the Imaging Core will acquire high-resolution MRI data prior to DBS implantation and a head CT scan after surgery. Images will be fused to provide a comprehensive anatomical model of the DBS target and the precise location of individual DBS contacts within each target. The Imaging Core will provide patient-specific anatomical models, precise post-surgery DBS lead localization, and parcellation of the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) to their functional sub-regions. These images will provide unparalleled anatomical characterization specific to each individual. Subject specific models of anatomical and functional connectivity developed by the Imaging Core will provide data that is vital for the completion of each project in the UMN Udall Center.

抽象的 明尼苏达大学（UMN）Udall Imaging Core，由Noam Harel博士领导。并位于大学 明尼苏达州国际知名的磁共振研究中心（CMRR）将获得国家 - 项目和催化剂中所有受试者的高分辨率MRI。 UMN Udall的总体主题 中心是为帕金森氏病（PD）开发基于电路的新型深脑刺激（DBS）疗法。 作为所有三个拟议项目的基础，催化剂项目并与其他核心合作 支持该主题，成像核心的总体目标是使用高级成像功能直接 可视化DBS手术的解剖靶标，并提供精确的位置和方向 目标后植入后的个体刺激电极接触。 成像芯将结合几种尖端的MRI技术，包括高分辨率T1/T2S和 敏感性加权图像（SWI）。也将获得扩散加权成像（DWI） 拖拉术以创建目标区域和相关网络的患者特异性解剖模型。到 补充静态解剖连接信息，我们将使用 基于基于电路的认知功能/非运动区域的基于静止状态和任务的功能MRI（fMRI）数据。 对于项目1、2和催化剂，PD患者将使用由7 T MRI系统进行扫描 我们在CMRR的团队。另外，在将植入Medtronic感知的一部分PD患者中 系统，DBS-FMRI刺激的功能图将在3T MRI系统上收集。对于项目3，非人类 灵长类动物（NHP）将在新安装的首先在CMRR上进行10.5 T MRI扫描仪进行扫描。 对于每个PD患者和每个NHP，成像核心将在DBS之前获取高分辨率MRI数据 手术后的植入和头部CT扫描。图像将被融合以提供全面的解剖学 DBS目标的模型和每个目标中单个DBS触点的精确位置。 成像核将提供特定于患者的解剖模型，精确的手术后DBS铅定位， 丘脑下核（STN）和GLOBUS PALLIDUS（GPI）的内部片段和拟层 功能子区域。这些图像将提供针对每个图像的无与伦比的解剖表征 个人。成像核心开发的解剖和功能连接性的主题特定模型将 提供对UMN UDALL中心每个项目完成至关重要的数据。