INSIGHT: Integrated Models for the Development and Assessment of High Impact Chemicals and Materials

洞察力：高影响化学品和材料开发和评估的综合模型

• 批准号: 10097888
• 金额: $ 34.53万
• 依托单位: UNIVERSITY OF BIRMINGHAM
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10097888
• 关键词: INSIGHT; Integrated; Models; Development; Assessment; INSIGHT; Integrated; Models; Development; Assessment

Safe and sustainable by design (SSbD) chemicals and materials are crucial to address the challenges of modern society. However, lack of stakeholders’ coordination, limited accessto relevant data, and absence ofstandardised methods have thusfar hampered the emergence of a comprehensive approach to SSbD. INSIGHT will overcome these challenges by developing an innovative framework for mechanistic impact assessment of chemicals/materials. The INSIGHT framework will consist of a multi-layered approach that integrates data, models, and impact outcome pathway (IOP) graphs. INSIGHT will also provide curated and user-friendly FAIR data and computational models/ workflows. INSIGHT aims to foster a paradigm shift in the assessment of sustainability and safety of chemicals and materials, from a fragmented situation to a holistic and integrated approach. INSIGHT will provide decision maps as a part of its integrated framework to guide users through the decision-making process, aiding them in evaluating the social, economic, health and environmental impacts of chemicals/materials in a more efficient and comprehensive manner. The INSIGHT project is fully aligned with the EU principles of safety and sustainability and the European Green Deal. INSIGHT will support the development of policies in the areas of neutrality, biodiversity protection, public health, and circular economy, thus aiding the development of a dynamic economy respecting planet Earth as a whole, avoiding harm to humans and the environment. By democratising the use of cutting-edge AI methods to SSbD, INSIGHT will drive innovation towards a digital, circular, climate-neutral and sustainable economy. INSIGHT will help the industry to optimise development and production of chemicals/materials and derived products, support regulators and policymakers in informed decision making towards safer and more sustainable society, and pave the way for a comprehensive approach to SSbD.

设计（SSBD）化学药品和材料的安全可持续性对于应对现代社会的挑战至关重要。但是，缺乏利益相关者的协调，有限的访问相关数据以及缺乏标准化方法，因此阻碍了SSBD的全面方法的出现。 Insight将通过为化学/材料的机械影响评估创新框架来克服这些挑战。 Insight框架将洞察力还将提供精选且用户友好的公平数据以及计算模型/工作流程。 Insight旨在促进化学和材料的可持续性和安全性评估的范式转变，从零散的情况到整体和综合方法。 Insight将提供决策图作为其集成框架的一部分，以指导用户完成决策过程，以更有效，更全面的方式评估化学药品/材料对社会，经济，健康和环境的影响。洞察力项目与欧盟的安全与可持续性和欧洲绿色协议完全一致。洞察力将支持中立，生物多样性保护，公共卫生和循环经济领域的政策制定，从而有助于发展整个行星地球的动态经济的发展，避免对人类和环境的伤害。通过将最先进的AI方法民主化用于SSBD，洞察力将推动创新，朝着数字，循环，气候中性和可持续性经济发展。洞察力将帮助该行业优化化学/材料和衍生产品的开发和生产，为监管机构和政策制定者提供明智的决策，以实现对更安全，更可持续的社会的明智决策，并为SSBD的全面方法铺平道路。