Rodent Phenotyping Core

啮齿动物表型核心

• 批准号: 10488232
• 负责人: Michael G Anderson
• 金额: $ 17.98万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488232
• 关键词: Acute; Address; Animal Husbandry; Animal Model; Anterior; Area; Axon; Biological; Biological Assay; COVID-19; Categories; Collaborations; Consult; Consultations; Development; Disease; Dissection; Educational workshop; Electroretinography; Equipment; Experimental Designs; Fees; Fluorescein Angiography; Funding; Fundus; Goals; Gonioscopy; Housing; Human Resources; Injections; Investigation; Iowa; Light; Lighting; Measures; Mission; Modeling; Mus; Optic Nerve; Phenotype; Photography; Physiologic Intraocular Pressure; Procedures; Pupil light reflex; Rattus; Reproducibility; Research Personnel; Resources; Retina; Retinal Ganglion Cells; Rodent; Science; Services; Slide; System; Temperature; Testing; Time; Tissues; Training; United States National Institutes of Health; Universities; Vision; Vision Tests; Vision research; automated image analysis; base; behavior measurement; deep learning; experimental study; investigator training; multidisciplinary; pandemic disease; response; sperm cryopreservation; vision science

PROJECT SUMMARY The goal of the Rodent Phenotyping Core (RPC) is to increase the utility of mice and rats as model organisms for vision research at The University of Iowa. The availability of a centralized core for phenotyping will allow investigators to focus their resources on the science and discoveries underlying vision research, rather than on training each lab’s personnel to perform phenotyping. Such core-based services will yield more consistent and reproducible phenotyping measures and in turn maximize the power of NEI-funded investigators to make new discoveries. The RPC will have the capability to perform detailed phenotyping of the anterior segment (slit- lamp examination and photography, SD-OCT, gonioscopy, fluorescein angiography, and intraocular pressure recording) and the posterior segment (fundus examination/photography, electroretinogram, pupil light reflex, behavioral measurements of vision, acute suppression of activity by light, and testing of optokinetic response).

项目概要 啮齿动物表型核心 (RPC) 的目标是提高小鼠和大鼠的效用 爱荷华大学视觉研究模型生物的可用性。 表型分析的核心将使研究人员能够将资源集中在科学和 发现视觉研究的基础，而不是培训每个实验室的人员来执行 这种基于核心的服务将产生更加一致和可重复的结果。 表型分析措施，进而最大限度地发挥 NEI 资助的研究人员的力量，使 新发现。 RPC 将能够对眼前节（狭缝）进行详细的表型分析。 灯检查和摄影、SD-OCT、房角镜检查、荧光素血管造影和 眼压记录）和眼后段（眼底检查/照相， 视网膜电图、瞳孔光反射、视力行为测量、急性抑制 光活动和光动反应测试）。