CORE A: Administrative Core

核心 A：行政核心

• 批准号: 10482386
• 负责人: JESSICA KIRKLAND CALDWELL
• 金额: $ 52.88万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10482386
• 关键词: Academic support; Achievement; Administrative Personnel; Administrator; Advisory Committees; Animal Genetics; Annual Reports; Applications Grants; Basic Science; Biological Markers; Brain imaging; Career Mobility; Centers of Research Excellence; Clinic; Clinical; Clinical Research; Collaborations; Communities; Community Outreach; Cultural Diversity; Data; Data Set; Decision Making; Diagnostic Procedure; Ecosystem; Educational Curriculum; Environment; Evaluation; Evolution; Fostering; Funding; Future; Genetic Markers; Goals; Grant; Growth; Human Resources; Individual; Industry; Infrastructure; Investments; Leadership; Longitudinal cohort; Mentors; Methods; Mission; Monitor; Nerve Degeneration; Neurodegenerative Disorders; Neurosciences; Neurosciences Research; Nevada; Outcome; Pathway Analysis; Patients; Performance; Phase; Phenotype; Pilot Projects; Population Heterogeneity; Positioning Attribute; Process; Process Assessment; Program Development; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Science; Scientific Advances and Accomplishments; Secure; Service delivery model; Statistical Data Interpretation; Strategic Planning; Supervision; Surveys; Testing; Therapeutic Intervention; Training; Translational Research; Universities; Vision; Work; base; brain health; career; career development; cohesion; cohort; community engagement; data management; design; experience; fundamental research; improved; innovation; multidisciplinary; operation; pandemic disease; programs; rapid growth; recruit; research and development; response; southern nevada; statistics; success; translational neuroscience

SUMMARY/ABSTRACT Administrative Core The Administrative Core (AC) is spearheading the success of the Center for Neurodegeneration and Translational Neuroscience (CNTN). The CNTN is a multidisciplinary, thematically cohesive, mission-oriented, translational neuroscience research program focused on neurodegenerative diseases (NDD) in Southern Nevada (NV). The Center is a dynamic collaboration between the Cleveland Clinic Lou Ruvo Center for Brain Health (LRCBH) in Las Vegas, Nevada (NV), and the University of Nevada Las Vegas (UNLV). Our research center is very significant for the demographic evolution of Southern NV. This is evidenced by the fact that State Officials strongly support our project and interact regularly with AC leadership to inquire about progress and need for support. During CNTN Phase 1, the work accomplished by AC has transformed the translational neuroscience research environment in Southern NV. The significant achievements of AC are: 1- the investment in cutting-edge infrastructure for neuroscience and NDD research; 2- the mentoring of six Junior Investigators (JIs) who graduated with independent positions; 3- the creation of a Clinical and Translational Research Core (CTRC) to build and deeply phenotype a new longitudinal cohort of patients suffering NDD; and 4- the establishment of a Data Management and Statistics Core to securely store and manage large biomedical datasets and assist CNTN investigators with statistical analyses. AC has utilized the data compiled from innovative methods developed by the Assessment Unit to monitor the operations of CNTN Cores and projects. For Phase 2, the AC intends to exploit the data from the Assessment Unit for decision-making. The data will be scrutinized to strategize on how to optimize the development of research infrastructure that will support new projects, the career development of CNTN investigators, and sustainability beyond the COBRE support period. The first step in our strategy is the augmentation of the AC leadership with two co-Directors (Drs. Sabbagh and Kinney) and one Assistant Director (Dr. Cummings) to efficiently manage the rapid growth of the CNTN enterprise. Our new AC leadership ambitions to accomplish five specific aims during Phase 2. First, AC will enhance the coordination of CNTN Cores, projects, and advisory Committees. Second, the AC will advance scientific research by increasing the size of our cohort and fortifying fundamental research projects, including the projects by junior and pilot project investigators. Third, the AC will enhance the career development of all CNTN personnel. Fourth, the AC will foster a robust assessment process of CNTN activities to further use the data for decision-making. Fifth, AC will utilize COBRE, institutional, industry, and philanthropic support to accentuate the sustainable future of neuroscience research in Southern NV. Therefore, AC leaders are fully committed to develop the translational neuroscience research ecosystem in Southern NV and assist State Officials with finding an impactful response to curb the upcoming NDD pandemic in NV.

摘要/摘要 行政核心 行政核心（AC）率先于神经退行性中心和翻译中心的成功 神经科学（CNTN）。 CNTN是一种多学科的，主题的凝聚力，以任务为导向的，翻译 神经科学研究计划的重点是内华达州南部（NV）的神经退行性疾病（NDD）。这 中心是克利夫兰诊所Lou Ruvo大脑健康中心（LRCBH）之间的动态合作 内华达州维加斯（NV）和内华达大学拉斯维加斯大学（UNLV）。我们的研究中心非常重要 NV Southern NV的人口发展。国家官员强烈支持我们的事实证明了这一点 项目并定期与AC领导层进行互动，以询问进度和支持的需求。 在CNTN阶段1期间，AC完成的工作改变了转化神经科学 南北南部的研究环境。 AC的重大成就是：1-尖端的投资 神经科学和NDD研究的基础设施； 2-六名初级调查员（JIS）的指导 具有独立职位的毕业； 3-创建临床和转化研究核心（CTRC） 建立和深层表型，新的纵向NDD患者纵向队列； 4-建立 数据管理和统计核心，以安全地存储和管理大型生物医学数据集并协助CNTN 统计分析的研究人员。 AC利用了根据由创新方法编制的数据 评估单元监视CNTN内核和项目的运营。 对于第2阶段，AC打算利用评估单元的数据进行决策。数据将 仔细审查以制定如何优化将支持新的研究基础设施的发展 项目，CNTN调查人员的职业发展以及超越鞋垫支持期之外的可持续性。 我们战略的第一步是与两个联合主任的AC领导力的增强（Sabbagh博士和 Kinney）和一名助理董事（Cummings博士），以有效管理CNTN的快速增长 企业。我们在第2阶段实现五个特定目标的新的AC领导力野心。首先，AC将 加强CNTN内核，项目和咨询委员会的协调。第二，交流将前进 科学研究通过增加我们队列的规模和强化基本研究项目的规模，包括 初级和试点项目调查人员的项目。第三，AC将增强所有人的职业发展 CNTN人员。第四，AC将促进CNTN活动的强大评估过程，以进一步使用 决策数据。第五，AC将利用毛刺，机构，工业和慈善支持 强调南北南部神经科学研究的可持续未来。因此，交流领导者完全 致力于发展南北南部的转化神经科学研究生态系统并协助州 官员们发现有影响力的反应以遏制即将到来的NDD大流行。