Sustained Training in Aging and HIV Research (STAHR)

老龄化和艾滋病毒研究持续培训（STAHR）

基本信息

批准号：
10483564
负责人：
Scott L Letendre
金额：
$ 21万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10483564
关键词：
Acquired Immunodeficiency Syndrome Address Aging Applications Grants Appointment Area Award Bioinformatics Biological Markers Biometry Brain COVID-19 pandemic California Clinical Cognition Disorders Collaborations Complex Country Development Development Plans Distance Learning Educational workshop Elderly Ethics Faculty Family Practice Fostering Functional disorder Funding Funding Mechanisms Geriatrics Goals Grant Growth HIV Home Impaired cognition Individual Infrastructure Institution Intervention Knowledge Longevity Manuscripts Medicine Mental Health Mental disorders Mentors Mentorship Mood Disorders Morbidity - disease rate NIH Office of AIDS Research National Institute of Mental Health Neuronal Plasticity Neurosciences Outcome Measure Personal Satisfaction Persons Phase Polypharmacy Postdoctoral Fellow Premature aging syndrome Preventive Medicine Productivity Program Evaluation Psychiatry Public Health Publications Publishing Research Research Institute Research Personnel Research Project Grants Research Support Research Training Resources Science Scientist Secure Sum Training Training Activity Training Programs Underrepresented Minority Universities Weather Work aging brain career career development community engagement community involvement cultural competence design experience healthspan improved innovation interest medical schools mental development multidisciplinary neurobehavioral novel strategies premature prevent preventive intervention programs psychiatric comorbidity psychosocial stressors recruit resilience skills success summer institute translational scientist

项目摘要

This application proposes to continue to develop, implement, and evaluate the highly successful Sustained Training on Aging and HIV Research (STAHR) research training program, which has the goal of expanding the pool of NIMH-funded new investigators performing research of HIV, aging, and mental health. Since the initiation of the program in 2015, the lifespan of people with HIV (PWH) has continued to improve but the healthspan has not improved to the same extent, raising concerns about premature aging. Many key research questions regarding the complex relationship between HIV, aging, and the brain remain unanswered. This emerging field encompasses issues of physical and psychiatric disease, polypharmacy, cognitive impairment, and psychosocial stressors on the one hand, and positive aspects such as resilience and neuroplasticity on the other. Much remains to be learned about mechanisms and interventions for preventing and treating mental illnesses, including cognitive and mood disorders, in older PWH. Fostering the development of researchers with knowledge and expertise in both aging and HIV is critical for the promotion of urgently needed research in this field. The STAHR program builds on the infrastructure and expertise available at two major research programs at the University of California, San Diego (UCSD, the Stein Institute for Research on Aging and the HIV Neurobehavioral Research Program) and addresses several priorities of the NIMH Division of AIDS Research and the NIH Office of AIDS Research. The program targets clinical and translational postdoctoral fellows and junior faculty from across the country who have experience in aging or HIV research, but are interested in gaining expertise in the intersection of these two factors. Four new scholars are selected each year and are matched with a primary mentor at their home institution and a co-mentor at UCSD. Training goals are to increase knowledge and skills in HIV and aging mental health research and support career development, with mentoring being a key focus. Each scholar works with their mentors to develop an Individual Development Plan. Although many of the training activities are performed remotely throughout the 3-year program, we have all scholars and mentors convene annually for a 2-day Workshop at UCSD when public health allows. First year scholars also attend a 4-week Summer Institute that will be part in-person at UCSD and part remote. In its first funding cycle, the STAHR program trained a diverse group of 20 early-career scientists (50% underrepresented minorities). The program’s success thus far is evidenced by the impressive track record of publications, awarded grants, career milestones and the positive program evaluations. Thus far, the program has grown its network of mentors across the U.S., which has supported trainee development and fostered collaborations. With this renewal, the network will continue to grow and serve as a resource for trainees during and after the program. Overall, STAHR strives to develop high quality independently funded investigators, who will make lasting contributions to mental health research in HIV and aging.

该应用程序建议继续开发、实施和评估非常成功的持续老龄化和艾滋病毒研究培训 (STAHR) 研究培训计划，其目标是扩大自启动以来，由 NIMH 资助的一批新研究人员从事艾滋病毒、衰老和心理健康方面的研究。自 2015 年该计划以来，艾滋病毒感染者 (PWH) 的寿命持续延长，但健康寿命却下降了未得到同等程度的改善，是对过早衰老的担忧的许多关键研究问题。关于艾滋病毒、衰老和大脑之间的复杂关系，这个新兴领域仍然没有答案。涵盖身体和精神疾病、多重用药、损伤和心理社会问题一方面是压力源，另一方面是弹性和神经可塑性等积极方面。预防和治疗精神疾病的机制和干预措施仍有待了解，包括老年感染者的认知和情绪障碍促进研究人员的知识发展。老龄化和艾滋病毒方面的专业知识对于促进该领域迫切需要的研究至关重要。 STAHR 项目建立在两个主要研究项目的基础设施和专业知识的基础上加州大学圣地亚哥分校（UCSD，斯坦因衰老和艾滋病毒研究所）神经行为研究计划）并解决了 NIMH 艾滋病研究部门的几个优先事项该项目针对临床和转化博士后研究员和美国国立卫生研究院艾滋病研究办公室。来自全国各地的初级教师，他们有老龄化或艾滋病毒研究经验，但有兴趣获得每年都会选出四名新学者并进行匹配。与他们所在机构的主要导师和加州大学圣地亚哥分校的共同导师一起，培训目标是增加。艾滋病毒和老龄化心理健康研究方面的知识和技能，并在指导下支持职业发展每位学者都与他们的导师一起制定个人发展计划。在整个三年计划中，许多培训活动都是远程进行的，我们有所有学者和在公共卫生允许的情况下，导师每年都会在加州大学圣地亚哥分校召开为期两天的研讨会。参加为期 4 周的暑期学院，该学院将在第一个资助周期中部分在加州大学圣地亚哥分校亲自授课，部分远程授课。 STAHR 项目培训了由 20 名早期职业科学家组成的多元化群体（50% 为少数族裔）。迄今为止，该计划的成功体现在令人印象深刻的出版物记录、授予的资助、职业里程碑和积极的计划评估到目前为止，该计划已经扩大了其导师网络。通过这次更新，该组织支持了学员的发展并促进了合作。总体而言，STAHR 网络将继续发展，并在项目期间和之后为学员提供资源。致力于培养高素质的独立资助的研究人员，他们将为精神科学领域做出持久的贡献艾滋病毒和老龄化的健康研究。