THE PET RADIOTRACER TRANSLATION AND RESOURCE CENTER (PET-RTRC)

PET 放射示踪剂翻译和资源中心 (PET-RTRC)

• 批准号: 10480874
• 负责人: Robert J. Gropler
• 金额: $ 43万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10480874
• 关键词: Advisory Committees; Biometry; Budgets; Communication; Country; Data; Data Set; Development; Documentation; Ensure; Evaluation; Financial Support; Goals; Human Resources; Image; Image Analysis; Infrastructure; Institutional Review Boards; Lead; Location; Medical Imaging; Movement; National Institute of Biomedical Imaging and Bioengineering; Performance; Positron-Emission Tomography; Procedures; Progress Reports; Protocols documentation; Recommendation; Resource Informatics; Resources; Review Committee; Schedule; Scientist; Services; Standardization; Structure; Testing; Time; Toxicity Tests; Tracer; Training; Translations; Universities; Washington; base; clinical imaging; data management; data repository; design; first-in-human; meetings; member; operation; pre-clinical; quality assurance; quantitative imaging; radiotracer; technology research and development; translational pipeline

Administrative Core Project Summary The Administrative Core provides centralized services that support the administration of the PET Radiotracer Translation and Resource Center (PET-RTRC) and is responsible for continuity, coordination and oversight of its activities. The key components of this Core include: 1) Administrative Component: The administrative component will coordinate the general activities of the PET- RTRC to include, infrastructure and financial support, to facilitate communication within the PET-RTRC located at WU, between the WU location and our various Collaborative Projects (CPs) and Service Projects (SPs) located around the country, and between the Center and NIBIB, and organize the organize the PET- RTRC annual meeting. 2) Provide biostatistical support for Center activities 3) Establish the Quantitative Imaging & Informatics Resource: to ensure timely and standardized evaluation of radiotracer performance and to facilitate the movement and management of data throughout the PET-RTRC. 4) Establish the Tracer Review Committee: to provide broad overview and guidance on the performance of the various radiotracers under development at the Center and make recommendations to the Executive Committee. 5) Executive Committee: This committee will have major oversight functions of the PET-RTRC including: A) Review the performance of various radiotracers under development at the Center and the CPs, decide on the progression through the translational pipeline of candidate radiotracers; B) Oversee the distribution of radiotracers, precursors or other products from the Center to SPs; C) Evaluate requests for Center products by potential new SPs and; D) Serve as a resource to the CPs and SPs for guidance in using and/or evaluating radiotracers produced by the Center. 6) External Advisory Committee: The committee will be composed 4 experts who are scientists knowledgeable in the development and/or translation of radiotracers and/or the training of radiochemists and/or the application and use of radiotracers for medical imaging. It will provide input on the scientific and operational direction of the PET-RTRC The administrative structure has been devised to ensure the PET-RTRC can meet is scientific, training and dissemination goals.

行政核心项目概要 管理核心提供支持 PET 放射性示踪剂管理的集中服务 翻译和资源中心 (PET-RTRC)，负责翻译和资源中心的连续性、协调和监督 它的活动。该核心的关键组件包括： 1) 行政部门：行政部门将协调 PET 的一般活动 RTRC 将包括基础设施和财政支持，以促进 PET-RTRC 内部的沟通 位于 WU，位于 WU 地点和我们的各种合作项目 (CP) 和服务项目之间 （SP）位于全国各地以及中心和 NIBIB 之间，并组织 PET- RTRC 年会。 2）为中心活动提供生物统计支持 3）建立定量成像和信息学资源：确保及时、标准化的评估 放射性示踪剂性能并促进整个 PET-RTRC 中数据的移动和管理。 4) 建立追踪审查委员会：为追踪者的绩效提供广泛的概述和指导 中心正在开发的各种放射性示踪剂并向行政部门提出建议 委员会。 5) 执行委员会：该委员会将承担 PET-RTRC 的主要监督职能，包括： A) 审查中心和 CP 正在开发的各种放射性示踪剂的性能，决定 候选放射性示踪剂转化管道的进展； B) 监督分配 从中心到 SP 的放射性示踪剂、前体或其他产品； C) 评估对中心产品的请求 通过潜在的新 SP 以及； D) 作为 CP 和 SP 的资源来指导使用和/或评估 该中心生产的放射性示踪剂。 6) 外部顾问委员会：该委员会将由 4 名知识渊博的科学家专家组成 放射性示踪剂的开发和/或翻译和/或放射化学家的培训和/或 放射性示踪剂在医学成像中的应用和使用。它将提供科学和操作方面的投入 PET-RTRC 的方向 管理结构的设计确保 PET-RTRC 能够满足科学性、培训性和 传播目标。