Core 2: Biostatistics and Bioinformatics Core

核心2：生物统计学和生物信息学核心

基本信息

批准号：
10478976
负责人：
David Elashoff
金额：
$ 13.06万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10478976
关键词：
Adopted Applications Grants Area Basic Science Bioinformatics Biometry Clinical Investigator Clinical Research Clinical Trials Cloud Computing Computer software Consult Consultations Custom Data Data Analytics Development Education Ensure Evaluation Experimental Designs Flow Cytometry Gene Chips Genomics Goals Individual Leadership Malignant neoplasm of prostate Manuscripts Methodology Pathway Analysis Preparation Prostate Proteomics Publications Quality Control RNA Reporting Reproducibility Research Research Design Research Personnel Research Project Grants Resources Services Statistical Data Interpretation T cell receptor repertoire sequencing Technology Tissue Microarray Translational Research anticancer research base design exome gang high dimensionality member power analysis preclinical study programs tool translational study

项目摘要

PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core (BBC), will facilitate translational research in prostate cancer, by providing UCLA investigators and their colleagues with state of the art biostatistical, bioinformatics and clinical trials support. The BBC provides a centralized network of biostatistics and bioinformatics support for prostate cancer researchers at UCLA and their collaborators. The overall goal of the Core is to provide statistical and bioinformatic support to basic and clinical investigators in the SPORE. The statistical consulting will be led by Dr. David Elashoff and supported by Dr. Gang Li and will include consultation on power analyses and experimental design for planning of preclinical and clinical studies. The core will collaborate on the development of statistical analysis plans and assist with carrying out those plans. The Bioinformatics component will be led by Dr. Thomas Graeber and supported by Dr. Paul Boutros. The Core provides analytical services for all genomics research, including RNA/whole exome/T-cell receptor sequencing and proteomic analysis within the SPORE. For these data types the core will assist with data preprocessing, pipeline development and cloud computing, quality control evaluation, and both standard and custom integrative and network analysis. The core will assist with the reporting of research findings in manuscripts. Finally, the Biostatistics and Bioinformatics Core provides yearly educational seminars and courses to all SPORE investigators.

项目摘要/摘要生物统计学和生物信息学核心（BBC）将通过为UCLA调查人员及其同事提供最先进的生物统计学，生物信息学和临床试验支持。英国广播公司（BBC）提供了一个集中的生物统计学和生物信息学支持网络加州大学洛杉矶分校的癌症研究人员及其合作者。核心的总体目标是提供统计和对孢子中基本和临床研究者的生物信息学支持。统计咨询将由 David Elashoff博士，并由Lin Dr. Gang Li的支持，并将包括有关权力分析的咨询和临床前和临床研究计划的实验设计。核心将在开发方面合作统计分析计划并协助执行这些计划。生物信息学组件将被列由托马斯·格雷伯（Thomas Graeber）博士由保罗·布特罗斯（Paul Boutros）博士提供支持。核心为所有人提供分析服务基因组学研究，包括RNA/整个外显/T细胞受体测序和蛋白质组学分析孢子。对于这些数据类型，核心将有助于数据预处理，管道开发和云计算，质量控制评估以及标准和自定义集成和网络分析。核心将有助于报告手稿中的研究结果。最后，生物统计学和生物信息学核心向所有孢子调查人员提供年度教育研讨会和课程。