Biorepository/Pathology Core

生物样本库/病理学核心

• 批准号: 10478841
• 负责人: Amanda Nickles Fader
• 金额: $ 26.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10478841
• 关键词: Biological; Biological Assay; Biostatistics Core; Blood; Cell Therapy; Cells; Cervical; Clinical; Clinical Protocols; Collaborations; Consultations; County Hospitals; Cytology; Data Storage and Retrieval; Databases; Detection; Diagnostic; Discipline of obstetrics; Documentation; Enrollment; Experimental Designs; Female Genital Neoplasms; Gynecologic Oncology; Gynecologic Pathology; Gynecology; Histologic; Hospitals; Human; Image Analysis; Immunologics; Infrastructure; Institution; Joints; Liquid substance; Malignant Female Reproductive System Neoplasm; Malignant neoplasm of ovary; Microscopic; Molecular; National Research Council; Neoplasms; Oncology; Online Systems; Operating Rooms; Pathologic; Pathologist; Pathology; Patient Care; Pennsylvania; Photography; Prevention strategy; Process; Recommendation; Research Personnel; Research Project Grants; Resource Sharing; Resources; Safety; Scanning; Services; Site; Specimen; Study Subject; Supervision; Surgical Oncology; System; Tissue Procurements; Tissue Stains; Tissue Therapy; Tissues; Translational Research; Tumor Tissue; Universities; University Hospitals; Woman; Work; World Health Organization; algorithm development; base; biobank; biomarker development; data management; digital; digital imaging; human tissue; imaging biomarker; molecular pathology; neoplastic; novel therapeutics; oncology service; operation; programs; quantitative imaging; repository; software development; success; tissue preparation; tissue processing; tumor; tumor xenograft

BIOREPOSITORY/ PATHOLOGY CORE: PROJECT SUMMARY The Biorepository/Pathology Core will collect and distribute clinically annotated human biospecimens related to ovarian cancer and will provide pathologic expertise and support for tissue-based analyses for investigators in the Johns Hopkins-University of Pennsylvania (UPENN) Ovarian Cancer SPORE. The main resource and operation of this Core will be based on the current Gynecologic Cancer Biorepository (GCB) Bank that has been a co-joint operation among the JHU Oncology Center, the Kelly Gynecologic Oncology Service in the Department of Gynecology and Obstetrics, and the Division of Gynecologic Pathology. The GCB bank was established in 2000 and expanded through the support of a US DoD-sponsored program project and subsequently by the DoD-sponsored Ovarian Cancer Consortium Program. In addition, the Cellular Therapy Tissue Facility (CTTF) at UPENN will provide all tissue procurement and processing for Project 3 (at UPENN) and will procure and process tissue to support Projects 1 and 4 at JHU. The CTTF collects and processes fresh tumor tissue acquired directly from the operating rooms at the Hospital of the University of Pennsylvania and Pennsylvania Hospital, as well as from external institutions, including Chester County Hospital. Tissue will be shared between JHU and UPENN, as well with other collaborating institutions. Thus, the Ovarian Cancer SPORE Biorepository/Pathology Core will incorporate and build on a pre-existing infrastructure. In the last few years, the Repository has been expanded to include expert diagnostic pathology and molecular pathology consultation to investigators, including guidance for quantitative digital image analyses-guided molecular studies of tissues. Specimens are collected under the supervision of pathologists with expertise in gynecologic pathology, in close collaboration with gynecologic oncology surgical colleagues. Clinical information for subjects enrolled in our clinical protocols is entered into a password-protected web-based tracking system, which follows the recommendations of the National Research Council. A review mechanism is in place for prioritization of distribution of requested resources to investigators within and external to this Ovarian Cancer SPORE.

生物座席/病理核心：项目摘要 生物疗法/病理核心将收集和分发与 卵巢癌，将为研究人员提供病理专业知识和支持 宾夕法尼亚州（Upenn）卵巢癌孢子的约翰·霍普金斯大学。主要资源和 该核心的操作将基于当前的妇科癌症生物库（GCB）银行 曾是JHU肿瘤学中心的共同连接，凯利妇科肿瘤科服务 妇科与妇产科系，以及妇科病理学的划分。 GCB银行是 成立于2000年，并通过美国国防部赞助的计划项目的支持而扩展 随后由国防部赞助的卵巢癌财团计划。另外，细胞疗法 UPENN的组织设施（CTTF）将为3（UPENN）提供所有组织采购和处理 并将采购和处理组织以支持JHU的项目1和4。 CTTF收集和流程 直接从宾夕法尼亚大学医院的手术室收购的新鲜肿瘤组织 宾夕法尼亚医院以及包括切斯特县医院在内的外部机构。组织会 在JHU和UPENN之间共享，以及其他合作机构。因此，卵巢癌 Spore Biorepository/Pathology Core将在先前存在的基础架构上合并并建立。在最后几个 多年来，存储库已扩展到包括专家诊断病理学和分子病理学 向研究人员进行咨询，包括定量数字图像指导的指导分子 组织研究。在具有妇科专业知识的病理学家的监督下收集标本 病理学，与妇科肿瘤学手术同事密切合作。临床信息 我们临床协议中注册的受试者将进入一个基于密码保护的网络跟踪系统， 遵循国家研究委员会的建议。审核机制已适当 优先考虑向卵巢癌内部和外部调查人员分配所请求的资源 孢子。