Skin Translational Research

皮肤转化研究

基本信息

批准号：
10477231
负责人：
Aimee S Payne
金额：
$ 13.96万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10477231
关键词：
3-Dimensional Age Applications Grants B-Lymphocytes Biological Biological Assay Biology Blood specimen Cell Line Cell physiology Cells Clinical Clinical Data Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Computerized Medical Record Consultations Data Dermatology Disease Disease model Drug Delivery Systems Evaluation FDA approved Fibroblasts Fostering Freezing Future Genetic Engineering Genetic Screening Genomics Genotype Goals Grant Human Immunodeficient Mouse Inflammatory Informed Consent Infrastructure Institution Institutional Review Boards Investigation Learning Link Manuscripts Medical Medical Genetics Medicine Modeling Molecular Abnormality Participant Pathway interactions Patients Pharmacology and Toxicology Phenotype Publications Research Research Infrastructure Research Personnel Research Support Resources Robotics Sampling Services Site Skin Skin Physiology Skin Tissue Small Interfering RNA Technology Tissue Engineering Tissues Training Translational Research base biobank body system chemical genetics efficacy evaluation exome experience experimental study functional adaptation high throughput screening human disease in vitro Model in vivo in vivo Model innovation interest keratinocyte melanocyte neoplastic novel novel therapeutics sex skin disorder skin xenograft small hairpin RNA small molecule small molecule libraries stem targeted treatment transcriptomics

项目摘要

PROJECT SUMMARY The Skin Translational Research (STaR) Core aims to foster innovative and pathophysiologically relevant skin biology and disease research by facilitating experiments using human primary samples. Fresh human skin and primary skin cells are highly valuable resources that help to extend skin research throughout the larger scientific community at our institution, evidenced by the large number of investigators outside the Department of Dermatology who have previously used our Core services and subsequently submitted new abstracts, publications, and grant applications on skin biology. By combining highly utilized primary tissue services with innovative tissue engineering, high-throughput screening, and biobanking consultation and services, STaR Core aims to maximize our impact within an even broader scientific community. Our long-term objectives are to: (1) allow investigators both within and outside the Department of Dermatology to conduct research on skin biology more efficiently and effectively by centralizing high-volume or specialized technical services and providing the critical research infrastructure and institutional review board approvals for their use; (2) foster innovative exploratory projects and junior investigators in skin biology through our core services, with the goal of promoting new scientific collaborations, abstracts, manuscripts, and grants; (3) promote translational research by providing access to normal and diseased human skin samples that might not otherwise be available to non-physicians or have substantial administrative barriers to their use; and (4) integrate our core directors’ research expertise into future core services to adapt to the emerging needs and opportunities of our membership. To accomplish these goals we aim to: 1) Accelerate novel pathway discovery through both targeted investigations of candidate pathways as well as unbiased high-throughput screening assays in primary human skin cells; 2) Enable 3-dimensional skin biology and disease modeling through ex vivo human skin cultures, organotypic skin cultures, and human skin xenografts; and 3) Promote research using well- annotated skin biospecimens by establishing the Penn Dermatology BioBank, which includes both normal and diseased human skin samples, with or without paired blood samples, including linked clinical and genetic data.

项目摘要皮肤转化研究（Star）核心旨在促进创新和病理生理学相关的皮肤生物学和疾病研究通过促进人类主要样本促进实验。新鲜的人类皮肤和初级皮肤细胞是高度宝贵的资源，有助于扩展皮肤研究我们机构的科学界，由部门以外的大量调查人员证明皮肤病学以前使用过我们的核心服务并随后提交了新摘要，出版物，并授予皮肤生物学的申请。通过将高度利用的主要组织服务与创新的组织工程，高通量筛查以及生物库咨询和服务，明星核心旨在最大程度地发挥我们在更广泛的科学界的影响。我们的长期目标是至：（1）允许皮肤科内外的调查人员对皮肤进行研究通过集中大量或专业技术服务，更有效，有效地生物学提供关键的研究基础设施和机构审查委员会的使用批准；（2）寄养通过我们的核心服务，创新的探索性项目和皮肤生物学的初级调查人员的目标促进新的科学合作，摘要，手稿和赠款；（3）促进翻译通过提供访问正常和解散的人类皮肤样本的研究，否则非物理学家可用或具有实质性的行政障碍；（4）整合了我们的核心董事对未来核心服务的研究专业知识，以适应我们的新兴需求和机会会员资格。为了实现这些目标，我们的目的是：1）通过两者加速新的途径发现对候选途径的有针对性研究以及公正的高通量筛查测定法原代人皮细胞； 2）通过体内人类启用三维皮肤生物学和疾病建模皮肤培养，有机皮肤培养和人类皮肤饰面； 3）促进研究通过建立Penn皮肤病学生物库，包括正常和患病的人皮肤样本，有或没有配对的血液样本，包括连接的临床和遗传数据。