Component for Institution # 269291

机构组件

• 批准号: 10475407
• 负责人: Tricia Helen Burdo
• 金额: $ 25万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-05 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475407
• 关键词: Address; Aging; Area; Award; Basic Science; Behavior Disorders; Behavioral; Behavioral Research; Behavioral Sciences; Biological Assay; Brain; Cardiovascular system; Cells; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Cost Sharing; Development; Discrimination; Ensure; Evaluation; Faculty; Feedback; Financial Support; Fostering; Functional disorder; Funding; Future; Genes; Goals; Grant; HIV; HIV-1; In Vitro; Infection; Infrastructure; Institution; Interpersonal Relations; Investigation; Leadership; Malignant Neoplasms; Manuscripts; Measures; Medicine; Mental Depression; Mentors; Mentorship; Metabolic Activation; Microscopic; Minority Health Research; Mission; Molecular; National Institute of Mental Health; Neuropsychology; Office of Administrative Management; Performance; Persons; Pilot Projects; Play; Postdoctoral Fellow; Preparation; Process; Progress Reports; Publishing; Reporting; Request for Applications; Research; Research Personnel; Research Priority; Review Committee; Role; Scientist; Services; Social Sciences; Strategic Planning; Structure; Testing; Time; Training; Underrepresented Minority; Universities; Work; base; career; career development; cohort; college; comorbidity; design; experience; gender disparity; graduate student; high risk; immune activation; innovation; interdisciplinary approach; interdisciplinary collaboration; medical schools; member; multidisciplinary; neuroAIDS; neurocognitive disorder; next generation; novel; novel therapeutics; organizational structure; outreach; pandemic disease; programs; recruit; responsible research conduct; senior faculty; sexual disparity; side effect; social; social stigma; socioeconomic disparity; success; synergism

SUMMARY The current HIV-1 pandemic is one where people living with HIV (PWH) have had well-suppressed infection with therapy for prolonged periods of time. This has guided research towards focusing on (i) comorbidities (aging, cardiovascular, cancer, metabolic, and immune activation), (ii) side effects of ART, (iii) neurocognitive and behavioral disorders (occurs approximately 40% of time), (iv) socioeconomic inequalities, stigma and discrimination, sexual and gender disparities, interpersonal relations, and neuropsychological problems including depression across the PWH community, and (v) new therapeutics and cure strategies. Research advances in these diverse areas require an interdisciplinary approach with participation of investigators in basic, behavioral, and clinical research. Toward this end, the overall aim of the Developmental Research and Mentorship Core (DRMC) is to provide support for innovative pilot projects in neuroHIV and. HIV research addressing emerging scientific priorities and mentorship of the next generation of HIV researchers. The DRMC will provide infrastructure and support for pilot investigations, progress evaluation, guidance, and mentorship. This Core application describes the progress during the current funding period, experience of the Core Directors, the process to recruit and review innovative project applications, and the role the Core will play in mentorship of clinical and basic science faculty and trainees at various levels. In the last five years (years 6-10), 19 (5 from cost share) awards were given mostly to junior investigators. Awardees of pilot monies have been extremely successful with 31 published manuscripts and 9 grants awarded from research related to the recent pilot grants. Over the next 5-year period, the DRMC will fund six pilot applications per year. Two will be funded by the. DRMC and four from institutional support to provide a more optimal pilot project program and to expand our efforts to enhance the recruitment and development of underrepresented minority (URM) research investigators. With regards to mentorship, the short-term goal is to assist junior, more senior faculty new to HIV, and URM faculty in developing a successful proposal for pilot study funds. The long-term goal will be to provide training and mentorship to awardees that will foster and strengthen their careers in neuroHIV into the future. The DRMC will provide an organization and structure that will effectively integrate new project development, funding of preliminary research, mentorship and establishing new interdisciplinary collaborations. The DRMC will work closely with the Central Adminstrative and Management Core (CAMC) and scientific cores to promote high research priorities and overarching objectives of the CNHC. It is anticipated that this core will play a pivotal role in enhancing and ensuring the success of neuroHIV investigators, expand outreach and support of URM, and advance neuroHIV research and execution of the CNHC mission.

概括 当前的HIV-1大流行是艾滋病毒（PWH）患者对感染的感染。 长时间的治疗。这引导了研究专注于（i）合并症（老化， 心血管，癌症，代谢和免疫激活），（ii）艺术的副作用，（iii）神经认知和 行为障碍（大约发生的时间约为40％），（iv）社会经济不平等，污名和 歧视，性和性别差异，人际关系以及神经心理学问题，包括 PWH社区的抑郁症，以及（V）新的治疗和治疗策略。研究进展 这些不同的领域需要一种跨学科的方法，研究人员参与基本，行为， 和临床研究。为此，发展研究和指导核心的总体目的 （DRMC）是为Neurohiv的创新试点项目提供支持。艾滋病毒研究针对新兴 下一代艾滋病毒研究人员的科学重点和指导。 DRMC将提供 基础设施和支持试点调查，进度评估，指导和指导的支持。这个核心 申请描述了当前资金期间的进度，核心董事的经验， 招募和审查创新项目应用程序的过程，以及核心将在指导中的作用 临床和基础科学教师和学员在各个层面上。在过去的五年（6-10年）中，19（5 成本份额）奖励主要是给初级调查人员的。飞行员的获奖者非常非常 成功获得了31项已出版的手稿和9条赠款，该研究与最近的试点赠款有关。 在接下来的5年期间，DRMC每年将资助六个试点申请。两个将由。 DRMC 从机构支持中提供了四个，以提供更优化的试点项目计划，并将我们的努力扩展到 增强代表性不足的少数族裔（URM）研究人员的招聘和发展。和 关于指导的方面，短期目标是协助初中，艾滋病毒新手的高级教师和URM教师 在制定成功的试点研究基金的建议中。长期目标是提供培训和 将向获奖者提供指导，这些获奖者将促进和加强他们在神经hiv的职业发展。 DRMC会 提供将有效整合新项目开发的组织和结构 初步研究，指导和建立新的跨学科合作。 DRMC将工作 与中央管理和管理核心（CAMC）和科学核心密切相关，以促进高 CNHC的研究重点和总体目标。预计该核心将发挥关键作用 在增强和确保神经hiv研究者的成功，扩大对URM的外展和支持以及 推进CNHC任务的神经凝血研究和执行。