Bioinformatics and Pathways Core

生物信息学和通路核心

基本信息

批准号：
10474291
负责人：
Jonathan Daniel Wren
金额：
$ 37.65万
依托单位：
OKLAHOMA MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-03-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10474291
关键词：
Animal Model Applications Grants Award Bioinformatics Biological Centers of Research Excellence ChIP-seq Chemicals Computer software Core Facility Data Analyses Data Sources Databases Development Developmental Biology Doctor of Philosophy Ensure Funding Gene Expression Genes Genetic Transcription Genomic Segment Genomics Grant High-Throughput Nucleotide Sequencing Human Resources Informatics Institution Literature Meta-Analysis Methods Oklahoma Participant Pathway Analysis Pathway interactions Peer Review Phase Phenotype Pilot Projects Preparation Property Publications Published Comment Publishing Quality Control Research Research Design Research Personnel Research Project Grants Resource Informatics Sample Size Scientist Transcript Troglodytinae Untranslated RNA Work base bioinformatics infrastructure design differential expression disease phenotype experience experimental analysis experimental study interest novel power analysis programs public database skills statistics tool transcriptome sequencing

项目摘要

Abstract This Developmental Biology Phase II COBRE Bioinformatics and Pathways Core (BPC) will provide dedicated bioinformatics and statistical support for all Junior Investigators and Pilot Project Investigators. In particular, we will help with processing, quality control, analysis and interpretation of high-throughput sequencing experiments such as RNA-seq, ChIP-seq, and genomic analyses. Additionally, the BPC has a dedicated Ph.D.-level statistician who will provide continuous statistical support, both in the design and interpretation of experiments. We have extensive experience in the effective use of state-of-the-art bioinformatics methods and software, as well as a track record in developing novel methods to help interpret experimental findings. We will also work proactively with the Junior Investigators to identify how informatics approaches can help their research, and develop new informatics resources accordingly. The BPC will help and support COBRE investigators as they submit their grants for independent research funding, both in preparation of the relevant sections on data analysis and statistics, as well as in post-award analyses. The BPC is led by Dr. Jonathan Wren, a bioinformatician with 128 peer-reviewed publications and 14 years of experience, and two Ph.D.-level scientists on staff. Our top priorities are to continue to build our bioinformatics infrastructure to help Junior Investigators and Pilot Project Investigators with data analysis, data interpretation and identification of promising new experimental leads.

抽象的这种发育生物学阶段II柯布雷生物信息学和途径核心（BPC）将提供为所有初级调查人员和试点项目调查人员提供专门的生物信息学和统计支持。在特别是，我们将帮助进行高通量的处理，质量控制，分析和解释测序实验，例如RNA-SEQ，CHIP-SEQ和基因组分析。此外，BPC有一个专门的博士级统计学家将在设计和实验的解释。我们在有效使用最先进的方面有丰富的经验生物信息学方法和软件，以及开发新方法以帮助解释的记录实验发现。我们还将与初级调查人员积极合作，以确定信息学如何方法可以帮助他们的研究，并相应地开发新的信息学资源。 BPC会有所帮助并支持毛茸茸的调查员在向独立研究资金的赠款提交赠款时，都在在数据分析和统计数据以及雄辩后的分析中准备相关部分。这 BPC由生物信息学家乔纳森·雷恩（Jonathan Wren）博士领导，有128个同行评审的出版物和14年经验，以及两位职员的博士学位科学家。我们的首要任务是继续建立我们的生物信息学帮助初级调查人员和试点项目调查员进行数据分析，数据解释的基础架构并确定有希望的新实验线索。