Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with Asthma

室内超细颗粒物暴露与哮喘儿童呼吸系统发病率、炎症和氧化应激之间的关系

• 批准号: 10470611
• 负责人: EMILY BRIGHAM
• 金额: $ 16.37万
• 依托单位: UNIVERSITY OF BRITISH COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-10 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470611
• 关键词: Acute; Adult; Adult asthma; Affect; Air Pollution; Albuterol; Alveolus; Area; Asthma; Attenuated; Award; Baltimore; Biolectric Impedance; Biological; Biological Markers; Blood Circulation; Body mass index; Caliber; Cell membrane; Characteristics; Child; Childhood; Childhood Asthma; Chronic; Cities; Clinical Trials Design; Critical Care; Data; Development; Diet; Dietary intake; Dose; Environment; Environmental Exposure; Erythrocytes; Exposure to; Fatty Acids; Fatty acid glycerol esters; Foundations; Funding; Future; Growth; Health; Health Benefit; Heating; Home; Home environment; Human; Incidence; Individual; Indoor Air Pollution; Indoor environment; Inflammation; Inflammatory; Infrastructure; Intake; Intervention; Investigation; Leadership; Link; Literature; Low Income Population; Low income; Lung; Lung diseases; Measurement; Measures; Mediation; Medicine; Metabolic; Metabolism; Methods; Minority; Modification; Monitor; Morbidity - disease rate; Nasal Epithelium; Non obese; Nutritional; Obesity; Omega-3 Fatty Acids; Outcome; Oxidative Stress; Parents; Participant; Particulate Matter; Patient Self-Report; Penetration; Play; Population; Positioning Attribute; Predisposition; Public Health Schools; Research; Research Personnel; Resources; Respiratory Disease; Respiratory Tract Infections; Risk Factors; Role; Serum; Source; Spirometry; Surface; Symptoms; Time; Training; Ultrafine; Unhealthy Diet; United States; United States National Institutes of Health; Universities; Work; airway inflammation; asthma inhaler; base; biological adaptation to stress; career; coarse particles; cooking; dietary; environmental tobacco smoke; epidemiology study; experience; fine particles; health assessment; indoor exposure; inner city; interest; medical schools; minority children; mortality; novel; obesity in children; operation; particle; particle exposure; patient oriented; pollutant; portability; professor; pulmonary function; residence; respiratory; respiratory health; respiratory morbidity; response; skills; systemic inflammatory response; ultrafine particle; ventilation

Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with Asthma. Particulate matter (PM) is a criteria pollutant, and exposures have been linked with acute and chronic health effects, including respiratory morbidity and mortality. The smallest form of PM, ultrafine PM (UFP), enters and disperses freely in the lungs, and can translocate into the bloodstream. Because of their small size, UFPs have an enormously large surface area:particle mass ratio and carry adsorbed toxic contaminants known to incite inflammatory and oxidative stress responses. They are hypothesized to be among the most harmful components of PM to human health, and yet few epidemiologic investigations have been completed due to limitations in monitoring capabilities only recently overcome. Furthermore, the sources of these particles are often unique, and indoor exposures (i.e. cooking, heating, environmental tobacco smoke) contribute heavily to individual exposure. Dr. Brigham, Assistant Professor in Pulmonary and Critical Care Medicine at Johns Hopkins University, has a strong interest in the effects of these particles on respiratory disease. She has extensive research experience in epidemiologic studies of asthma health and metabolic risk factors for asthma morbidity in both adult and pediatric populations, and conducts her research within a group combining resources from the Johns Hopkins School of Medicine and adjacent Bloomberg School of Public Health with the expertise to support indoor UFP monitoring. Dr. Brigham's proposal seeks to define the impact of indoor UFP exposure on children with asthma in Baltimore City, a uniquely susceptible population with a historically disproportionate burden of indoor air pollution and more than twice the national average of prevalent asthma. She proposes to investigate: (Aim 1) the effects of UFP exposure on pediatric asthma symptoms, lung function, and rescue-inhaler use, (Aim 2) the effects of UFP exposure on airway and systemic markers of oxidative stress and inflammation, and (Aim 3) mediation of the effects of UFP exposure on asthma health by additional modifiable metabolic factors known to affect response to larger PM: adiposity and dietary intake of omega-3 fatty acids. This award will not only provide an outstanding training vehicle for Dr. Brigham's development into an independent, NIH funded patient-oriented researcher, poised for leadership in investigations at the intersection of air pollution, metabolism, and respiratory health, but will also provide critically novel data regarding the impact of indoor UFP exposure in this vulnerable pediatric population.

室内超细颗粒暴露与呼吸道发病率，炎症和 哮喘儿童的氧化应激。 颗粒物（PM）是标准污染物，暴露与急性和慢性健康有关 影响，包括呼吸道发病和死亡率。最小的PM，Ultrafine PM（UFP），Enter和 自由分散在肺部，可以转移到血液中。由于它们的尺寸很小，UFP具有 一个极大的表面积：颗粒质量比，并携带已知会促进的吸附的有毒污染物 炎症和氧化应激反应。假设它们是最有害的组成部分之一 人类健康的PM，但由于限制的限制 监视功能直到最近才能克服。此外，这些粒子的来源通常是独一无二的， 和室内暴露（即烹饪，供暖，环境烟草烟）对个人有巨大贡献 接触。 约翰·霍普金斯大学肺部和重症监护医学助理教授Brigham博士已经 对这些颗粒对呼吸系统疾病的影响有浓厚的兴趣。她有丰富的研究经验 在成人和 小儿种群，并在一个组合约翰·霍普金斯的资源的小组中进行研究 医学院和邻近彭博公共卫生学院具有专业知识，以支持室内UFP 监视。 Brigham博士的提议旨在定义室内UFP暴露对哮喘儿童的影响 在巴尔的摩市，一个独特的易感人群，历史上有不成比例的室内空气负担 污染，是全国普遍哮喘的两倍以上。她建议调查：（目标1） UFP暴露对小儿哮喘症状，肺功能和救援人员使用的影响，（AIM 2） UFP暴露对气道和氧化应激和炎症的全身标志物的影响，以及（AIM 3） 通过已知的其他可修改代谢因素对UFP暴露对哮喘健康的影响调解 影响对较大PM的反应：Omega-3脂肪酸的肥胖和饮食摄入。 该奖项不仅将为Brigham博士开发提供出色的培训工具 独立，NIH资助的以患者为导向的研究人员，有望在交叉路口进行调查领导 空气污染，新陈代谢和呼吸道健康，但还将提供有关影响的重要数据 在这种脆弱的小儿人群中，室内UFP暴露。

项目成果

Childhood Origins of Adult Lung Disease as Opportunities for Prevention.

• DOI: 10.1016/j.jaip.2020.01.015
• 发表时间: 2020-03
• 期刊: The journal of allergy and clinical immunology. In practice
• 作者: Grant T;Brigham EP;McCormack MC
• 通讯作者: McCormack MC

The Authors Reply.

• DOI: 10.1038/ki.2015.131
• 发表时间: 2015-07
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: Dong Z

Lung Health Disparities in Time.

肺部健康的时间差异。

• DOI: 10.1001/jamainternmed.2021.2572
• 发表时间: 2021
• 期刊: JAMA internal medicine
• 影响因子: 39
• 作者: Brigham,Emily;Raju,Sarath
• 通讯作者: Raju,Sarath

Patterns and predictors of air purifier adherence in children with asthma living in low-income, urban households.

• DOI: 10.1080/02770903.2021.1893745
• 发表时间: 2022-05
• 期刊: The Journal of asthma : official journal of the Association for the Care of Asthma
• 作者: Kaviany P;Brigham EP;Collaco JM;Rice JL;Woo H;Wood M;Koehl R;Wu TD;Eakin MN;Koehler K;Hansel NN;McCormack MC
• 通讯作者: McCormack MC