Collaborative Pediatric Critical Care Research Network - Clinical Site

儿科重症监护协作研究网络 - 临床网站

• 批准号: 10468846
• 负责人: Robinder Khemani
• 金额: $ 8.75万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-13 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10468846
• 关键词: Admission activity; Anesthesiology; Anticoagulation; Beds; Binding Sites; Biological; Biomedical Engineering; California; Cardiac; Cardiopulmonary Bypass; Caring; Child; Childhood; Clinical; Clinical Trials; Coagulation Process; Complement; Consensus; Contracts; County; Critical Care; Critical Illness; Data; Data Coordinating Center; Data Science; Development; Emotional; Enrollment; Ensure; Epigenetic Process; Ethnic Origin; Faculty; Funding; Future; Genetic; Goals; Good Clinical Practice; Health; Hemorrhage; Hispanic; Immune; Individual; Infant; Informatics; Infrastructure; International; Knowledge; Leadership; Los Angeles; Lung; Mechanical ventilation; Medicine; Mentors; Mentorship; Methods; Monitor; Morbidity - disease rate; Multi-Institutional Clinical Trial; National Heart, Lung, and Blood Institute; Neonatology; Neurocognitive; Observational Study; Oranges; Patient Care; Patients; Pediatric Acute Lung Injury; Pediatric Acute Respiratory Distress Syndrome; Pediatric Hospitals; Pediatric Intensive Care Units; Performance; Phenotype; Positioning Attribute; Practice Guidelines; Procedures; Protocols documentation; Pulmonology; Research; Research Personnel; Research Training; Respiratory Diaphragm; Respiratory Disease; Running; Sampling; Scientist; Sepsis; Site; Socioeconomic Factors; Talents; Treatment outcome; United States National Institutes of Health; Ventilator; Work; clinical center; clinical research site; computerized; design; ethnic diversity; expectation; functional status; health related quality of life; immunoregulation; implementation science; innovation; interest; meetings; member; mortality; multidisciplinary; participant enrollment; pulmonary function; racial diversity; recruit; respiratory; socioeconomic diversity; success; support tools; symposium; translational scientist; ventilation; virtual

PROJECT SUMMARY/ABSTRACT – Children's Hospital Los Angeles This application details the qualifications, interest and commitment of Children's Hospital Los Angeles (CHLA) to be a member of the Collaborative Pediatric Critical Care Research Network (CPCCRN). CHLA and its investigators in the division of critical care are international experts in pediatric mechanical ventilation, Pediatric Acute Respiratory Distress Syndrome (PARDS), informatics and data science. Led by Dr. Khemani (PI) and Dr. Newth (Co-I), the multi-disciplinary CHLA respiratory research group and its members have led large multi-center observational studies in PARDS (PARDIE study, 145 international ICUs), and have spearheaded international practice guidelines related to mechanical ventilation and PARDS. This group is currently running a highly innovative single center clinical trial using a computerized decision support tool targeting lung and diaphragm protective ventilation in pediatric ARDS, which includes comprehensive assessment of post-ICU morbidity. These unique qualifications and expertise will greatly enrich the scientific rigor and breadth of knowledge within the CPCCRN. In addition, other CHLA investigators are pioneers in data science, neurocritical care and implementation science, and will bring this expertise to the CPCCRN. CHLA is at the forefront of collaborative research, with several faculty holding leadership positions in the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the Pediatric Neurocritical Care Research Group, and multi-center data collaboratives such as VPS, VPICU, and the PICU Data Collaborative. This expertise underscores our faculty's ability to be highly collaborative in a research network to achieve common goals. It is therefore not surprising that CHLA has been the highest enroller in a multitude of multi-center clinical trials and observational studies in pediatric critical care. To further enhance our ability to recruit a large number of diverse patients into the CPCCRN studies, we will partner with an ancillary site at Children's Hospital of Orange County (CHOC). CHOC has been participating in multi-center collaborative research through the PALISI network for over 10 years and has also achieved remarkably high enrollment rates in clinical trials. Through our two centers, we can ensure that the clinical trial(s) conducted in the CPCCRN capture the unique ethnic, racial, and socio-economic diversity of Southern California which includes > 50% of patients being of Hispanic ethnicity. This is imperative for the proposed clinical trial on immune-modulation in sepsis, given the impact that genetic, epigenetic, environmental, and socio-economic factors may have on treatment and outcomes. Our site has several highly talented faculty and junior investigators who will not only contribute to the success of the CPCCRN but can be further mentored and developed into future thought leaders and clinical/translational researchers through the CPCCRN. CHLA is fully committed to be an engaged and highly productive member of the CPCCRN and execute the clinical trial described in the application.

项目摘要/摘要 - 洛杉矶儿童医院 此应用程序详细介绍了洛杉矶儿童医院（CHLA）的资格，兴趣和承诺 成为协作小儿重症监护研究网络（CPCCRN）的成员。 CHLA及其重症监护部调查人员是小儿机械的国际专家 通风，小儿急性呼吸窘迫综合征（PARS），信息和数据科学。由博士领导 Khemani（PI）和Newth博士（Co-I），多学科CHLA呼吸研究小组及其成员 在PARDS（PARDIE研究，145 ICUS）中领导了大型多中心观察研究，并具有 与机械通气和帕克有关的带头国际实践指南。这个组是 目前使用计算机化决策支持工具进行了高度创新的单中心临床试验 针对肺和膜片保护小儿ARDS中的通风，其中包括综合 评估ICU后发病率。这些独特的资格和专业知识将极大地丰富科学 CPCCRN中的知识严格和广度。此外，其他CHLA调查人员是数据中的先驱 科学，神经关怀和实施科学，将把这种专业知识带入CPCCRN。 Chla是 在协作研究的最前沿，有几个教师在小儿急性中担任领导职务 肺损伤和败血症研究人员（PALISI）网络，儿科神经护理研究小组和 多中心数据协作，例如VPS，VPICU和PICU数据协作。这个专业知识 强调了我们教师在研究网络中高度协作以实现共同目标的能力。这是 因此，CHLA一直是多中心临床试验中的最高参与者并不奇怪 小儿重症监护的观察性研究。为了进一步增强我们招募大量的能力 多样化的患者进入CPCCRN研究，我们将与儿童医院的辅助部位合作 奥兰治县（巧克力）。 CHOC一直在通过The Multi-Center协作研究 Palisi网络已有10多年的历史，在临床试验中也取得了很高的入学率。 通过我们的两个中心，我们可以确保在CPCCRN中进行的临床试验捕获独特 南加州的种族，种族和社会经济多样性，包括> 50％的患者 西班牙种族。考虑到拟议的败血症免疫调节临床试验，这是必须的 影响遗传，表观遗传学，环境和社会经济因素可能对治疗和 结果。我们的网站有几位才华横溢的教师和初级调查员，他们不仅会为 CPCCRN的成功，但可以进一步指导并发展成为未来的思想领袖和 通过CPCCRN进行临床/翻译研究人员。 CHLA完全致力于参与 CPCCRN的生产成员并执行应用中描述的临床试验。